| 李大千,蒋 云,邰 萍,吴剑锋,刘才冬.血清miR-200a和S-100B与妊娠期高血压疾病患者临床参数的关系及诊断价值分析[J].,2021,(23):4467-4471 |
| 血清miR-200a和S-100B与妊娠期高血压疾病患者临床参数的关系及诊断价值分析 |
| Analysis of the Relationship between Serum mir-200a and S-100B and Clinical Parameters in Hypertensive Disorders Complicating Pregnancy and Their Diagnostic Value |
| 投稿时间：2021-04-10 修订日期：2021-04-30 |
| DOI：10.13241/j.cnki.pmb.2021.23.014 |
| 中文关键词: 妊娠期高血压疾病 miR-200a S-100B 病情 诊断 |
| 英文关键词: Hypertensive disorders complicating pregnancy miR-200a S-100B Illness Diagnosis |
| 基金项目:江苏省科技发展计划项目（BE2017610） |
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| 中文摘要: |
| 摘要 目的：检测妊娠期高血压疾病（HDCP）患者血清miR-200a和S-100钙结合蛋白B(S-100B)水平，分析其与HDCP患者临床参数的关系及对HDCP的诊断价值。方法：检测2017年2月至2019年2月我院收治的182例HDCP患者（观察组）和153例健康孕妇（对照组）血清miR-200a、S-100B水平，并比较不同年龄、入组时体质量指数（BMI）、分娩孕周、孕次、产次、病情程度、预后的HDCP患者血清miR-200a、S-100B水平差异。Pearson相关性分析血清miR-200a、S-100B及有关指标间的相关性。受试者工作特征（ROC）曲线分析血清miR-200a、S-100B水平诊断HDCP的价值。结果：观察组血清miR-200a、S-100B水平均高于对照组（P＜0.05），血清miR-200a、S-100B水平随着病情加重而升高（P＜0.05）。血清miR-200a水平与HDCP患者年龄、入组时BMI、预后有关（P＜0.05），血清S-100B水平与HDCP患者分娩孕周、预后有关（P＜0.05）。Pearson相关分析结果显示，HDCP患者血清miR-200a与S-100B、年龄、入组时BMI呈正相关（P＜0.05），血清S-100B与分娩孕周呈正相关（P＜0.05）。ROC分析结果显示，血清miR-200a、S-100B水平诊断HDCP的曲线下面积（AUC）分别为0.743、0.721，灵敏度和特异度分别为72.93%、74.59%；72.00%、75.00%。结论：HDCP患者血清miR-200a、S-100B水平升高，两者与HDCP发病、进展和预后均存在密切关系。miR-200a、S-100B可能作为辅助HDCP诊断的生物学指标。 |
| 英文摘要: |
| ABSTRACT Objective: To detection the expression characteristics of serum mir-200a and s-100 calcium-binding protein B(S-100B) in patients with hypertensive disorders complicating pregnancy (HDCP), and analyze the relationship between miR-200a and S-100B in patients with HDCP, and its diagnostic value for HDCP. Methods: The serum miR-200a and S-100B levels of 182 HDCP patients (observation group) and 153 healthy pregnant women (control group) admitted to our department of obstetrics and gynecology from February 2017 to February 2019 were detected. The differences of serum miR-200a and S-100B in patients with HDCP were compared at different ages, body mass index (BMI) at enrollment, gestational week, gestation time, birth time, disease severity and prognosis. Pearson correlation analysis of serum miR-200a, S-100B and correlation between related indexes, and receiver operator characteristics curve (ROC) was used to analyze the value of serum miR-200a and S-100B levels in diagnosing HDCP. Results: Serum miR-200a and S-100B levels in the observation group were higher than those in the control group (P<0.05). The levels of serum miR-200a and S-100B increased with the aggravation of the disease (P<0.05). Serum miR-200a level was associated with age, BMI at enrollment and prognosis of HDCP patients (P<0.05), and serum S-100B level was associated with gestational age and prognosis of HDCP patients (P<0.05). Pearson correlation analysis showed that serum miR-200a was positively correlated with S-100B, age and BMI at enrollment in patients with HDCP (P＜0.05), Serum S-100B was positively correlated with gestational age (P＜0.05). ROC analysis showed that the AUC of serum miR-200a and S-100B in HDCP diagnosis was 0.743 and 0.721 respectively, and the sensitivity and specificity were 72.93% ,74.59%, 72.00%, 75.00% respectively. Conclusion: The serum miR-200a and S-100B levels of HDCP patients were increased, which were closely related to the incidence, progression and prognosis of HDCP. MiR-200a and S-100B can be used as valuable biological indicators for HDCP diagnosis. |
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