| 朱佳欢,蔡志敏,杨文芬,俞艾洁,陈曦慧.癫痫患者睡眠障碍特点及失眠症状与认知功能、焦虑抑郁的关系研究[J].,2021,(23):4463-4466 |
| 癫痫患者睡眠障碍特点及失眠症状与认知功能、焦虑抑郁的关系研究 |
| Study on the Relationship between the Sleep Disorder Characteristics, Insomnia Symptoms and Cognitive Function, Anxiety and Pepression in Patients with Epilepsy |
| 投稿时间：2021-04-06 修订日期：2021-04-30 |
| DOI：10.13241/j.cnki.pmb.2021.23.013 |
| 中文关键词: 癫痫 睡眠障碍 认知功能 抑郁 焦虑 |
| 英文关键词: Epilepsy Sleep disorder Cognitive function Depression Anxiety |
| 基金项目:江苏省卫生计生委基金项目（QNRC2016366） |
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| 中文摘要: |
| 摘要 目的：探讨癫痫患者的睡眠障碍特点，分析失眠症状与认知功能、焦虑抑郁的关系。方法：纳入我院2018年2月至2020年6月收治的120例癫痫患者为研究对象（癫痫组），依据失眠严重指数量表（ISI）总分将其分为失眠组（ISI总分≥15分）与无失眠组（ISI总分＜15分）。另选取50例健康体检者为健康对照组，探讨癫痫患者睡眠障碍特点，分析失眠症状与认知功能和焦虑抑郁的关系。结果：癫痫组匹兹堡睡眠质量指数量表（PSQI）评分（4.45±1.26）分、ISI评分（12.35±5.63）分、Epworth嗜睡量表（ESS）评分（6.32±3.54）分均高于健康对照组的（3.11±1.03）分、（9.62±5.14）分、（5.12±3.06）分，差异有统计学意义（P＜0.05）。癫痫失眠者占19.17%（23/120），无失眠者占80.83%（97/120）。失眠组病程、ISI评分、发作类型与无失眠组比较差异有统计学意义（P＜0.05）。失眠组蒙特利尔认知评估量表(MoCA)总分低于无失眠组，贝克抑郁量表第2版（BDI-Ⅱ）评分、贝克焦虑量表（BAI）评分高于无失眠组，差异有统计学意义（P＜0.05）。Pearson相关分析显示：癫痫患者ISI总分与MoCA总分呈负相关（P＜0.05），与BDI-Ⅱ评分、BAI评分呈正相关（P＜0.05）。结论：癫痫患者多存在睡眠障碍，且认知功能、焦虑抑郁症状与失眠症状密切相关。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the sleep disorders characteristics in patients with epilepsy, and to analyze the relationship between insomnia symptoms and cognitive function, anxiety and depression. Methods: A total of 120 patients with epilepsy who were admitted to our hospital from February 2018 to June 2020 were included as the research subjects (epilepsy group), and they were divided into insomnia group (ISI score ≥15 scores) and non-insomnia group (ISI score < 15 scores) according to the total score of insomnia severity index scale (ISI). Another 50 healthy subjects were selected as the healthy control group, the characteristics of sleep disorders in epilepsy patients were discussed, and the relationship between insomnia symptoms and cognitive function and anxiety and depression was analyzed. Results: The Pittsburgh Sleep Quality Scale (PSQI) score (4.45±1.26) scores, ISI score (12.35±5.63) scores and Epworth Sleepiness Scale (ESS) score (6.32±3.54) scores in epilepsy group were higher than those in healthy control group (3.11±1.03) scores, (9.62±5.14) scores and (5.12±3.06) scores, the differences were statistically significant (P<0.05). The patients with epilepsy with insomnia accounted for 19.17% (23/120), and without insomnia accounted for 80.83% (97/120) respectively. There were significant differences in the disease course, ISI score and seizure type between the epilepsy with insomnia group and without insomnia group (P＜0.05). The Montreal cognitive assessment scale (MoCA) total score in epilepsy with insomnia group was lower than that in the without insomnia group, Beck depression inventory Edition 2 (BDI-Ⅱ) score, Beck anxiety inventory (BAI) score were higher than those in the without insomnia group, the differences were statistically significant (P＜0.05). Pearson correlation analysis showed that the total ISI score of epilepsy patients was negatively correlated with the total MOCA score (P＜0.05), and the BDI-Ⅱ score, BAI score were positively correlated (P＜0.05). Conclusion: Most patients with epilepsy have sleep disorder, and cognitive function, anxiety and depression symptoms are closely related to insomnia symptoms. |
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