| 刘鸿儒,李 俊,陆 明,郭秀岚,李明涛.电针深刺八髎穴对脾肾阳虚型溃疡性结肠炎患者Th17/Treg细胞免疫平衡和血清炎症因子的影响[J].,2021,(22):4293-4297 |
| 电针深刺八髎穴对脾肾阳虚型溃疡性结肠炎患者Th17/Treg细胞免疫平衡和血清炎症因子的影响 |
| The Effect of Electroacupuncture Deep Acupuncture Ba Qian Point on Immune Balance of Th17/Treg Cells and serum Inflammatory Factors in Patients with Ulcerative Colitis with Spleen-kidney Yang Deficiency Type |
| 投稿时间：2021-03-27 修订日期：2021-04-23 |
| DOI：10.13241/j.cnki.pmb.2021.22.019 |
| 中文关键词: 电针深刺八髎穴 脾肾阳虚型溃疡性结肠炎 Th17/Treg细胞 免疫平衡 炎症因子 |
| 英文关键词: Electroacupuncture deep acupuncture Ba Qian point Ulcerative colitis with spleen-kidney Yang deficiency type Th17/Treg cells Immune balance Inflammatory factors |
| 基金项目:天津市卫生和计划生育委员会项目（2015022） |
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| 中文摘要: |
| 摘要 目的：观察电针深刺八髎穴对脾肾阳虚型溃疡性结肠炎（UC）患者的治疗效果，并探讨其作用机制。方法：选取自2020年3月~2021年2月期间天津市人民医院收治的80例脾肾阳虚型UC患者。采用随机数字表法分为对照组和研究组2组，各为40例，对照组接受常规西医治疗，研究组在常规西医治疗基础上联合电针深刺八髎穴治疗，对比两组患者疗效、中医证候积分、血清炎症因子水平、Th17/Treg细胞。结果：与对照组相比，研究组可进一步提高临床总有效率（P<0.05）。治疗2周后，研究组畏寒肢冷、腹部冷痛、晨起泄泻评分低于对照组（P<0.05）。治疗2周后，研究组血清?酌-干扰素（IFN-γ）、白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）水平低于对照组（P<0.05）。治疗2周后，研究组Th17细胞水平、Th17/Treg比值低于对照组，Treg细胞水平高于对照组（P<0.05）。结论：电针深刺八髎穴可促进脾肾阳虚型UC患者症状改善，同时该治疗方案还具有调节Th17/Treg细胞免疫平衡，降低血清炎症因子水平的作用。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the therapeutic effect of electroacupuncture deep acupuncture Ba Qian point on patients with ulcerative colitis (UC) with spleen-kidney Yang deficiency type, and to explore its mechanism. Methods: A total of 80 patients with UC with spleen-kidney Yang deficiency type who were admitted to Tianjin People's Hospital from March 2020 to February 2021 were selected. Using random number table method, they were divided into control group and study group, with 40 cases in each group. The control group received conventional western medicine treatment, and the study group received electroacupuncture deep acupuncture Ba Qian point treatment on the basis of conventional western medicine treatment. The curative effect, traditional Chinese medicine syndrome integral, serum inflammatory factor level and Th17/Treg cells were compared between the two groups. Results: Compared with the control group, the total clinical effective rate of the study group could be further improved (P<0.05). 2 weeks after treatment, the scores of intolerance to cold and cold limbs, abdominal cold pain and diarrhea in the morning of the study group were lower than those of the control group(P<0.05). 2 weeks after treatment, serum levels of γ-interferon (IFN-γ), interleukin-6(IL-6) and tumor necrosis factor-α (TNF-α) of the study group were lower than those of the control group(P<0.05). 2 weeks after treatment, the Th17 cell level and Th17/Treg ratio of the study group were lower than those of the control group, and the Treg cell level was higher than that of the control group(P<0.05). Conclusion: Electroacupuncture deep acupuncture Ba Qian point can improve the symptoms of patients with UC with spleen-kidney Yang deficiency type. At the same time, this treatment also has the effect of regulating the immune balance of Th17/Treg cells, and reducing the level of serum inflammatory factors. |
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