| 刘 悦,屈乐言,白 雪,汤晓冬,李伟红.右归饮加减方联合"固本通络"针法对类风湿性关节炎患者血清炎性因子和细胞免疫功能的影响[J].,2021,(19):3660-3664 |
| 右归饮加减方联合"固本通络"针法对类风湿性关节炎患者血清炎性因子和细胞免疫功能的影响 |
| Effect of Yougui Decoction Plus Minus Prescription Combined with "GubenTongluo"Acupuncture Therapy on Serum Inflammatory Factors and Immune Function of Patients with Rheumatoid Arthritis |
| 投稿时间：2021-04-20 修订日期：2021-05-15 |
| DOI：10.13241/j.cnki.pmb.2021.19.012 |
| 中文关键词: 类风湿性关节炎 右归饮加减方 "固本通络"针法 炎性因子 细胞免疫 |
| 英文关键词: Rheumatoid arthritis Yougui decoction plus minus prescription "GubenTongluo" acupuncture therapy Inflammatory response Immune function |
| 基金项目:上海市教育科学研究项目（C17070） |
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| 摘要 目的：探讨右归饮加减方联合"固本通络"针法对类风湿性关节炎患者血清炎性因子和细胞免疫功能的影响。方法：按照随机数表法将我院于2018年1月至2020年1月收治的105例患者分为对照组（n=52）和研究组（n=53）。对照组给予西医常规治疗，研究组在其基础上给予右归饮加减方联合"固本通络"针法治疗，两组均连续治疗3个月。统计两组的临床总有效率，分别于治疗前后测定DAS-28积分和症状体征指数积分，于治疗前后检测患者类风湿因子（RF）、红细胞沉降率（ESR）、肿瘤坏死因子-α（TNF-α）、C反应蛋白（CRP）、白细胞介素-6（IL-6）、白细胞介素-1（IL-1）水平及外周血CD3+、CD4+、CD8+水平。结果：研究组的临床总有效率明显比对照组高（P<0.05）。两组治疗后DAS-28积分、症状体征指数积分、CRP、RF、ESR、CD8+及血清TNF-α、IL-1及IL-6水平均明显小于治疗前（P<0.05），CD3+、CD4+均明显大于治疗前（P<0.05），研究组治疗后症状体征指数积分、DAS-28积分、RF、CRP、ESR、CD8+及血清TNF-α、IL-1及IL-6水平均明显小于对照组（P<0.05），CD3+、CD4+均明显大于对照组（P<0.05）。结论：右归饮加减方联合"固本通络"针法治疗类风湿性关节炎的疗效明确，有助于改善细胞免疫功能、抑制炎症反应及减轻临床症状。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of yougui decoction plus minus prescription combined with "GubenTongluo" acupuncture therapy on serum inflammatory factors and immune function of patients with rheumatoid arthritis. Methods: According to the random table method, 105 cases of patients with rheumatoid arthritis admitted to our hospital from January 2018 to January 2020 were divided into control group (n=52) and the study group (n=53). The patients in the control group were treated with conventional western medicine treatment, while the patients in the study group were treated with yougui decoction plus minus prescription combined with "GubenTongluo" acupuncture therapy on the basis of the control group, the two groups were treated for 3 months. The clinical total effective rate of two groups of patients was counted. The DAS-28 integral and symptom and sign index integral were measured before and after treatment, at the same time, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), interleukin-6 (IL-6) and peripheral blood CD3+, CD4+ and CD8+ levels were measured before and after treatment. Results: The total effective rate of study group was significantly higher than that of the control group (P<0.05). The DAS-28 integral, symptom and sign index integral, CRP, RF, ESR, CD8+ and serum TNF-α, IL-1, IL-6 levels of the two groups were significantly lower than before treatment (P<0.05), the CD3+, CD4+ were significantly higher than before treatment (P<0.05). Meanwhile, the DAS-28 integral, symptom and sign index integral, CRP, RF, ESR, CD8+ and serum TNF-α, IL-1 and IL-6 levels of the study group were significantly lower than the control group (P<0.05), CD3+ and CD4+ were significantly higher than the control group (P<0.05). Conclusion: The clinical curative effect of yougui decoction plus minus prescription combined with "GubenTongluo" acupuncture therapy for the treatment of rheumatoid arthritis is significantly, which can significantly reduce the clinical symptoms, inhibit inflammatory response and improve cellular immune function. |
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