| 祁亚宁,王利新,刘 辉,白春林,刘 勇.血清TM、P-selectin、HDL-C以及凝血功能指标与创伤性骨折患者术后深静脉血栓形成的关系研究[J].,2021,(16):3131-3135 |
| 血清TM、P-selectin、HDL-C以及凝血功能指标与创伤性骨折患者术后深静脉血栓形成的关系研究 |
| Study on the Relationship between TM, P-selectin, HDL-C, Coagulation Function and Postoperative Deep Vein Thrombosis in Patients with Traumatic Fracture |
| 投稿时间：2021-01-06 修订日期：2021-01-30 |
| DOI：10.13241/j.cnki.pmb.2021.16.027 |
| 中文关键词: 血栓调节蛋白 P-选择素 高密度脂蛋白 凝血功能 创伤性骨折 深静脉血栓 影响因素 |
| 英文关键词: Thrombomodulin P-selectin High density lipoprotein Coagulation function Traumatic fracture Deep venous thrombosis Influencing factors |
| 基金项目:宁夏回族自治区科学技术厅项目（2018AAC03262） |
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| 中文摘要: |
| 摘要 目的：探讨血清血栓调节蛋白（TM）、P-选择素（P-selectin）、高密度脂蛋白（HDL-C）以及凝血功能指标与创伤性骨折患者术后深静脉血栓形成（DVT）的关系。方法：选择2018年1月至2020年1月我院收治的术后发生DVT的创伤性骨折患者100例作为DVT组，同期术后未发生DVT的创伤性骨折患者100例作为无DVT组，比较两组血清TM、P-selectin、HDL-C、血浆凝血功能指标[凝血酶时间（TT）、凝血酶原时间（PT）、活化部分凝血酶时间（APTT）、纤维蛋白原（FIB）、D-二聚体（D-D）]，应用Pearson相关性分析血清TM、P-selectin、HDL-C与凝血功能指标的相关性，应用多因素Logistic回归分析创伤性骨折患者术后DVT的影响因素。结果：DVT组血清TM、P-selectin、血浆D-D、FIB水平、年龄≥60岁比例高于无DVT组，血清HDL-C水平低于无DVT组（P＜0.05）。DVT组血清TM和P-selectin与血浆D-D、FIB呈正相关（P＜0.05），血清HDL-C与血浆D-D、FIB呈负相关（P＜0.05）。多因素Logistic回归分析显示，年龄≥60岁、血清TM≥9.50 IU/mL、P-selectin ≥70.00 ng/mL、HDL-C<1.00 mmol/L、血浆D-D≥700.00 μg/L、FIB≥4.00 g/L是创伤性骨折患者术后DVT的危险因素（P＜0.05）。结论：创伤性骨折患者术后发生DVT患者血清TM、P-selectin较无DVT患者升高，HDL-C较无DVT患者降低，联合检测血清TM、P-selectin、HDL-C和凝血功能指标可能有助于降低DVT的发生风险。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum thrombomodulin (TM), P-selectin, high density lipoprotein (HDL-C) and coagulation function and postoperative deep vein thrombosis (DVT) in patients with traumatic fracture. Methods: 100 cases of traumatic fracture patients with postoperative occurrence DVT from January 2018 to January 2020 in our hospital were selected as the DVT group, at the same time, and 100 cases of traumatic fracture patients without DVT as the non DVT group. The serum TM, P-selectin, HDL-C, plasma coagulation function index [thrombin time (TT), prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), D-Dimer (D-D)] were compared between the two groups. Ultivariate logistic regression was used to analyze the influencing factors of DVT in patients with traumatic fracture. Results: The serum TM, P-selectin, plasma D-D, FIB levels and proportion of age ≥60 years in the DVT group were higher than those in the non DVT group, and the serum HDL-C levels were lower than those in the non DVT group (P＜0.05). In DVT group, serum TM and P-selectin were positively correlated with plasma D-D and FIB (P＜0.05), while serum HDL-C was negatively correlated with plasma D-Dand FIB (P＜0.05), and there were no significant correlation with other plasma coagulation function indexes (P>0.05). Multivariate Logistic regression analysis showed that age ≥60 years, serum TM≥9.50 IU/mL, P-selectin ≥70.00 ng/ml, HDL-C<1.00 mmol/L, plasma D-D≥700.00 g/L and FIB≥4.00 g/L were the risk factors of postoperative DVT in patients with traumatic fractures (P＜0.05). Conclusion: In patients with traumatic fractures, the serum TM and P-selectin are higher than those without DVT, and HDL-C is lower than those without DVT, Combined detection of serum TM, P-selectin, HDL-C and coagulation function indicators may help to reduce the risk of DVT. |
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