| 王 宏,丛培珊,王 君,王伟娜,辛 颖,于丽华.高尿酸血症患者血清尿酸水平与糖耐量异常、炎症因子及红细胞参数的相关性分析[J].,2021,(16):3084-3087 |
| 高尿酸血症患者血清尿酸水平与糖耐量异常、炎症因子及红细胞参数的相关性分析 |
| Correlation Analysis of Serum Uric Acid Level and Impaired Glucose Tolerance, Inflammatory Factors and Erythrocyte Parameters in Patients with Hyperuricemia |
| 投稿时间：2021-02-06 修订日期：2021-02-28 |
| DOI：10.13241/j.cnki.pmb.2021.16.017 |
| 中文关键词: 高尿酸血症 尿酸 糖耐量指标 炎症因子 红细胞参数 相关性 |
| 英文关键词: Hyperuricemia Uric acid Glucose tolerance index Inflammatory factors Red blood cell parameters Correlation |
| 基金项目:山东省自然科学基金项目（ZR2012HM046） |
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| 中文摘要: |
| 摘要 目的：探讨高尿酸血症（HUA）患者血清尿酸（UA）水平与糖耐量异常、炎症因子及红细胞参数的相关性。方法：选取2020年1月~2021年1月期间我中心在健康体检中诊断的HUA患者240例（观察组），另选取同期在我中心体检的健康志愿者200例（对照组），分别检测血清UA、炎症因子：超敏C反应蛋白（hs-CRP）、单核细胞趋化蛋白1（MCP-1）、白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、红细胞参数：红细胞分布宽度（RDW）、红细胞平均体积（MCV）及红细胞计数、糖耐量指标：空腹血糖（FPG）、餐后2h血糖（2hPG）及空腹胰岛素（FINS），计算稳态模型胰岛素抵抗指数（HOMA-IR）和稳态模型胰岛素敏感指数（HOMA-ISI）。结果：观察组的UA、RDW及红细胞计数均高于对照组，MCV低于对照组（P<0.05）。观察组的hs-CRP、MCP-1、IL-6及TNF-α均高于对照组（P<0.05）。观察组的FPG、2hPG、FINS及HOMA-IR均高于对照组，HOMA-ISI低于对照组（P<0.05）。Pearson相关系数指出，HUA患者血清UA水平与红细胞计数、RDW、hs-CRP、MCP-1、IL-6、TNF-α、FPG、2hPG、FINS及HOMA-IR呈正相关，而与HOMA-ISI、MCV呈负相关（P<0.05）。结论：高尿酸水平可引起HUA患者炎症反应增强、糖耐量异常及红细胞参数改变，控制UA水平可减少多种并发症的发生风险。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation between serum uric acid (UA) level and impaired glucose tolerance, inflammatory factors and erythrocyte parameters in patients with hyperuricemia (HUA). Methods:: 240 patients with HUA diagnosed in physical examination in our center from January 2020 to January 2021 were selected (observation group), another 200 healthy volunteers who came to our center for physical examination in the same period were selected (control group). Serum UA, inflammatory factors: high sensitivity C-reactive protein (hs-CRP), monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), red blood cell parameters: red blood cell distribution width (RDW), mean corpuscular volume (MCV), and red blood cell count, glucose tolerance indexes: fasting plasma glucose (FPG), 2h postprandial blood glucose (2hPG) and fasting insulin (FINS) were detected , homeostasis model insulin resistance index (HOMA-IR) and homeostasis model insulin sensitivity index (HOMA-ISI) were calculated. Results: UA, RDW and red blood cell count of the observation group were higher than those of the control group, and MCV was lower than that of the control group (P<0.05). The hs-CRP, MCP-1, IL-6 and TNF-α of the observation group were higher than those of the control group (P<0.05). FPG, 2hPG, FINS and HOMA-IR of the observation group were higher than those of the control group, and HOMA-ISI was lower than that of the control group (P<0.05). Pearson correlation coefficient showed that serum UA level was positively correlated with red blood cell count, RDW, hs-CRP, MCP-1, IL-6, TNF-α, FPG, 2hPG, FINS and HOMA-IR, but negatively correlated with HOMA-ISI and MCV (P<0.05). Conclusion: High uric acid level can lead to increased inflammatory response, impaired glucose tolerance and changes in red blood cell parameters in patients with HUA. Controlling UA level can reduce the risk of various complications. |
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