| 奚剑敏,谭小宁,文 欢,陆伟倩,黄 劲.非小细胞肺癌组织PD-L1、TTF-1、SYN表达与临床病理特征及预后的关系研究[J].,2021,(13):2517-2521 |
| 非小细胞肺癌组织PD-L1、TTF-1、SYN表达与临床病理特征及预后的关系研究 |
| Study of the Expressions of PD-L1, TTF-1, SYN in Non-small Cell Lung Cancer and Its Relationships with Clinicopathological Features and Prognosis |
| 投稿时间：2020-12-07 修订日期：2020-12-31 |
| DOI：10.13241/j.cnki.pmb.2021.13.024 |
| 中文关键词: 非小细胞肺癌 程序性细胞死亡蛋白1配体 甲状腺转录因子-1 突触素 预后 病理特征 |
| 英文关键词: Non-small cell lung cancer Programmed cell death protein-1 ligand Thyroid transcription factor-1 Synaptophysin Prognosis Pathological features |
| 基金项目:国家自然科学基金青年基金项目（81503452） |
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| 中文摘要: |
| 摘要 目的：探讨非小细胞肺癌（NSCLC）组织程序性细胞死亡蛋白1配体（PD-L1）、甲状腺转录因子-1（TTF-1）、突触素（SYN）表达与临床病理特征及预后的关系。方法：对2013年2月至2015年2月期间在我院治疗的97例NSCLC患者进行研究。检测NSCLC组织以及癌旁组织中PD-L1、TTF-1、SYN表达。分析PD-L1、TTF-1、SYN表达与临床病理特征的相关性。Kaplan-Meier生存曲线分析不同PD-L1、TTF-1、SYN表达患者总生存率的差异。Cox比例风险回归分析NSCLC患者预后的影响因素。结果：与癌旁组织相比，NSCLC组织中PD-L1、TTF-1阳性表达升高，SYN阴性表达升高（P<0.05）。PD-L1、TTF-1、SYN表达均与TNM分期和淋巴结转移相关（P<0.05）。PD-L1、TTF-1阴性患者的生存率分别高于PD-L1、TTF-1阳性患者，SYN阴性患者的生存率低于SYN阳性患者（P<0.05）。Cox比例风险回归分析结果显示，TNM分期、PD-L1阳性表达、TTF-1阳性表达、SYN阴性表达、淋巴结转移是NSCLC患者预后的影响因素（P<0.05）。结论：NSCLC组织中PD-L1、TTF-1阳性表达升高，SYN阴性表达升高，并且均与TNM分期、淋巴结转移和预后相关，其在NSCLC的诊断和预后评估中具有一定临床价值。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expressions of programmed cell death protein 1 ligand (PD-L1), thyroid transcription factor-1 (TTF-1), synaptophysin（SYN）in non small cell lung cancer (NSCLC) tissue and its relationships with clinicopathological features and prognosis. Methods: 97 patients with NSCLC who were treated in our hospital from February 2013 to February 2015 were studied. The expressions of PD-L1, TTF-1, SYN in NSCLC tissue and paracancerous tissue were detected. The correlation between the expression of PD-L1, TTF-1, SYN and clinicopathological features were analyzed. Kaplan-Meier survival curve was used to analyze the differences in the overall survival rate of patients with different expressions of PD-L1, TTF-1, SYN. Cox proportional hazards regression was used to analyze the prognostic factors in NSCLC patients. Results: Compared with paracancerous tissue, the positive expression of PD-L1 and TTF-1 increased in NSCLC tissue, negative expression of SYN increased(P<0.05). The expression of PD-L1, TTF-1, SYN were all correlated with TNM stage and lymph node metastasis(P<0.05). The survival rates of PD-L1, TTF-1 negative patients were respectively higher than those of PD-L1, TTF-1 positive patients. The survival rate of SYN negative patients was lower than that of SYN positive patients(P<0.05). Cox proportional hazard regression analysis showed that TNM stage, PD-L1 positive expression, TTF-1 positive expression, SYN negative expression, lymph node metastasis were the prognostic factors for patients with NSCLC(P<0.05). Conclusion: The positive expression of PD-L1, TTF-1 are increase in NSCLC tissue, the negative expression of SYN are increase, and are all correlated with TNM stage, lymph node metastasis and prognosis, which has a certain clinical value in the diagnosis and prognosis evaluation of NSCLC. |
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