| 李佳潞,杨 俊,朱晓萍,李 波,陆婉秋.肺炎支原体肺炎合并喘息患儿血清25（OH）D3水平与肺功能的相关性及其影响因素分析[J].,2021,(11):2143-2147 |
| 肺炎支原体肺炎合并喘息患儿血清25（OH）D3水平与肺功能的相关性及其影响因素分析 |
| Analysis of Correlation between Serum 25 (OH) D3 Level and Pulmonary Function in Child Patients with Mycoplasma Pneumoniae Pneumonia Complicated with Wheezing and Its Influencing Factors |
| 投稿时间：2020-10-21 修订日期：2020-11-16 |
| DOI：10.13241/j.cnki.pmb.2021.11.032 |
| 中文关键词: 肺炎支原体肺炎 喘息 25-羟维生素D3 MP-IgM 肺功能 |
| 英文关键词: Mycoplasma pneumoniae pneumonia Wheezing 25-hydroxyvitamin D3 MP - IgM Pulmonary function |
| 基金项目:贵州省科技厅联合基金项目（黔科合LH字[2014]7133）；贵州省卫生计生委科学技术基金项目（gzwjkj2014-2-106） |
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| 中文摘要: |
| 摘要 目的：探讨肺炎支原体肺炎（MPP）患儿合并喘息的影响因素，分析血清25-羟维生素D3[25(OH)D-3]水平与MPP合并喘息患儿肺功能的关系。方法：选择2017年1月至2020年1月我院收治的90例MPP患儿，根据是否合并喘息将其分为MPP合并喘息组（39例）和MPP未合并喘息组（51例）。检测血清25(OH)D-3水平以及肺功能[最大呼气流速（PEF）、PEF占预计值百分比(PEF% pred)、第一秒用力呼吸容积（FEV1）、用力肺活量（FVC）、FEV1/FVC比值、FEV1占预计值百分比（FEV1%pred）]，Pearson相关性分析25(OH)D-3与MPP合并喘息患儿肺功能的关系，单因素及多因素Logistic回归分析影响MPP合并喘息的危险因素。结果：MPP合并喘息组血清25(OH)D-3水平、PEF、PEF% pred、FEV1/FVC比值、FEV1%pred低于MPP未合并喘息组（P＜0.05），Pearson相关性分析显示，MPP合并喘息组患儿血清25(OH)D-3水平与PEF、PEF% pred、FEV1/FVC比值、FEV1%pred均呈正相关（r=0.519、0.612、0.571、0.593，P＜0.05）。单因素分析显示，MPP合并喘息组年龄低于MPP未合并喘息组（P＜0.05），病程长于MPP未合并喘息组（P＜0.05），肺部啰音比例、嗜酸性粒细胞计数、MP-IgM抗体滴度高于MPP未合并喘息组（P＜0.05）。多因素Logistic回归分析结果显示低龄、肺部啰音、嗜酸性粒细胞计数增高、MP-IgM抗体滴度增加、25(OH)D-3减少是MPP合并喘息的危险因素（P＜0.05）。结论：MPP合并喘息患儿25(OH)D-3水平较低，低龄、肺部啰音、嗜酸性粒细胞计数增高、MP-IgM抗体滴度增加、25(OH)D-3缺乏为MPP合并喘息的危险因素，25(OH)D-3缺乏与MPP合并喘息患儿肺功能下降有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the influencing factors of mycoplasma pneumoniae pneumonia (MPP) complicated with wheezing in child patients, to analyze the relationship between serum 25-hydroxyvitamin D3[25(OH)D-3] level and pulmonary function in child patients with MPP combined with wheezing. Methods: 90 child patients with MPP who were admitted in our hospital from January 2017 to January 2020 were selected, they were divided into MPP complicated with wheezing group (39 cases) and MPP without wheezing group (51 cases) according to whether complicated with wheezing or not. Serum 25(OH)D-3 levels and pulmonary function [peak expiratory flow rate (PEF), PEF to predicted value percentage (PEF% pred), forced expiratory volume in the first second（FEV1）, forced vital capacity（FVC）, FEV1 / FVC ratio, FEV1 to predicted value percentage（FEV1%pred）], Pearson correlation was used to analyze the relationship between 25 (OH) D-3 and pulmonary function in child patients with MPP complicated with wheezing, multivariate logistic regression analysis was used to analyze the risk factors of MPP complicated with wheezing. Results: Serum 25 (OH) D-3 level, PEF, PEF% pred, FEV1/ FVC ratio, FEV1% pred in MPP complicated with wheezing group were lower than those of MPP without wheezing group (P＜0.05), Pearson correlation analysis showed, serum 25 (OH) D-3 level was positively correlated with PEF, PEF% pred, FEV1 / FVC ratio, FEV1% pred of child patients in MPP complicated with wheezing group (r = 0.519, 0.612, 0.571, 0.593, P＜0.05). The age of MPP complicated with wheezing group was lower than that of MPP without wheezing group (P＜0.05), the course of disease was longer than that of MPP without wheezing group (P＜0.05), the proportion of pulmonary rales, eosinophil count, the titer of MP-IgM antibody were higher than those of MPP without wheezing group (P＜0.05). The results of multivariate logistic regression analysis showed that young age, pulmonary rales, increased eosinophil count, increased MP-IgM antibody titer, decreased 25 (OH) D-3 were risk factors for MPP with wheezing (P＜0.05). Conclusion: The level of 25 (OH) D-3 is lower in child patients with MPP complicated with wheezing, young age, pulmonary rales, increased eosinophil count, increased MP-IgM antibody titer, 25 (OH) D-3 deficiency may be risk factors for MPP with wheezing, 25 (OH) D-3 deficiency is associated with decreased pulmonary function in child patients with MPP complicated with wheezing. |
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