| 张 蓉,王玉静,闫小宁,李 寅,李 彤,张彩晴.康复新液联合溶菌酶肠溶片治疗阿弗他溃疡的临床疗效观察及对血清炎症因子和SIgA表达的影响[J].,2021,(10):1942-1945 |
| 康复新液联合溶菌酶肠溶片治疗阿弗他溃疡的临床疗效观察及对血清炎症因子和SIgA表达的影响 |
| Clinical Observation of Kangfuxin Liquid Combined with Lysozyme Enteric Coated Tablets in the Treatment of Aphthous Ulcer and Its Influence on the Expression of Serum Inflammatory Factors and SIgA |
| 投稿时间：2020-12-02 修订日期：2020-12-24 |
| DOI：10.13241/j.cnki.pmb.2021.10.030 |
| 中文关键词: 康复新液 溶菌酶肠溶片 阿弗他溃疡 血清炎症因子 SIgA |
| 英文关键词: Kangfuxin Liquid Lysozyme enteric coated tablets Aphthous ulcer Serum inflammatory factors SIgA |
| 基金项目:陕西省创新能力支撑计划项目（2017KCF-27） |
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| 中文摘要: |
| 摘要 目的：探讨康复新液联合溶菌酶肠溶片治疗阿弗他溃疡的临床疗效观察及对血清炎症因子和SIgA（免疫球蛋白A）表达的影响。方法：选取我院2015年1月到2019年1月共收治的100例阿弗他溃疡患者，根据治疗方法分为观察组与对照组，每组50例患者。给予对照组患者口服葡萄糖酸锌、维生素C、维生素B联合口腔溃疡散常规治疗，给予观察组患者在对照组治疗基础上应用康复新液联合溶菌酶肠溶片治疗，对比两组患者的临床疗效果，对比两组患者血清炎症因子指标，对比两组患者SIgA和IgG，并对比两组患者的疾病复发情况。结果：对照组患者治疗总有效率为84.00 %，观察组患者治疗总有效率为95.00 %，观察组明显高于对照组（P＜0.05）；对比两组患者治疗前后的炎症因子水平发现，两组患者治疗前肿瘤坏死因子-α（tumor necrosis factor α，TNF-α）、白细胞介素-1β（interleukin-1β，IL-1β）、血栓素B2（thromboxane B2，TXB2）水平对比无明显差异（P＞0.05），两组患者治疗后TNF-α、IL-1β、TXB2水平明显降低，且观察组低于对照组（P＜0.05）；两组患者治疗前免疫球蛋白A（secretory immunoglobulinA，SIgA）和免疫球蛋白G（immunoglobulin G，IgG）指标对比无明显差异（P＞0.05），治疗后，观察组患者的SIgA指标明显高于对照组（P＜0.05），观察组患者的IgG指标明显低于对照组（P＜0.05）；通过对比两组患者的疾病复发情况发现，观察组患者3个月、6个月和12个月的疾病复发率明显低于对照组（P＜0.05）。结论：对阿弗他溃疡患者应用康复新液联合溶菌酶肠溶片治疗，能够提升患者的治疗效果，减轻患者炎症情况，减少患者疾病复发情况，值得临床应用推广。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical efficacy of Kangfuxin Liquid Combined with lysozyme enteric coated tablets in the treatment of aphthous ulcer and the expression of serum inflammatory factors and SIgA (immunoglobulin A). Methods: 100 cases of patients with aphthous ulcer were selected as the research objects from January 2015 to January 2019, and the patients were randomly divided into observation group and control group, with 50 patients in each group. The control group was given oral zinc gluconate, vitamin C, vitamin B combined with oral ulcer powder conventional treatment, and the observation group was given Kangfuxin Liquid Combined with lysozyme enteric coated tablets on the basis of the treatment of the control group. The clinical therapeutic effect, the serum inflammatory factor indexes ，the recurrence of the two groups were compared separately. Results: The total effective rate of the control group was 84.00%, as the observation group was 95.00%, which was significantly higher than that of the control group (P<0.05); the levels of TNF-α, IL-1 β and TXB2 in the two groups before and after treatment had no significant difference (P>0.05), and the levels of TNF-α, IL-1 β and TXB2 in the two groups were obvious after treatment After treatment, the SIgA index of the observation group was significantly higher than that of the control group (P<0.05), and the IgG index of the observation group was significantly lower than that of the control group (P<0.05); by comparing the disease recurrence of the two groups, it was found that the observation group was 3 months old The relapse rates of 6 months and 12 months in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion: Kangfuxin Liquid Combined with lysozyme enteric coated tablets in the treatment of patients with aphthous ulcer can improve the treatment effect of patients, reduce the inflammation of patients and reduce the recurrence of disease, which is worthy of clinical application and promotion. |
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