| 马洋洋,肖久伟,熊中原,刘彦培,杨 中.参芪扶正注射液联合多西他赛对乳腺癌患者外周血象、免疫功能及血清肿瘤标志物的影响[J].,2021,(10):1868-1871 |
| 参芪扶正注射液联合多西他赛对乳腺癌患者外周血象、免疫功能及血清肿瘤标志物的影响 |
| Effect of Shenqi Fuzheng Injection Combined with Docetaxel on Peripheral Blood Picture, Immune Function and Serum Tumor Markers in Patients with Breast Cancer |
| 投稿时间：2021-01-03 修订日期：2021-01-26 |
| DOI：10.13241/j.cnki.pmb.2021.10.014 |
| 中文关键词: 参芪扶正注射液 多西他赛 乳腺癌 外周血象 免疫功能 肿瘤标志物 |
| 英文关键词: Shenqi Fuzheng injection Docetaxel Breast cancer Peripheral blood picture Immune function Tumor markers |
| 基金项目:北京市科技计划项目（2015100392） |
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| 中文摘要: |
| 摘要 目的：观察参芪扶正注射液联合多西他赛对乳腺癌患者外周血象、免疫功能及血清肿瘤标志物的影响。方法：选取2018年1月~2019年12月我院收治的64例乳腺癌患者，根据信封抽签法将患者分为对照组（n=32，多西他赛治疗）和研究组（n=32，参芪扶正注射液联合多西他赛治疗）。对比两组疗效，对比两组治疗前、治疗2个疗程后的外周血象、免疫功能及血清肿瘤标志物，记录两组治疗期间不良反应情况。结果：比较两组不良反应无差异（P>0.05）。治疗2个疗程后，对照组的总有效率为43.75%（14/32），研究组的总有效率为68.75%（22/32），研究组的总有效率高于对照组（P<0.05）。治疗2个疗程后，两组血红蛋白、血小板、白细胞水平均较治疗前下降，但研究组高于对照组（P<0.05）。两组CD3+、CD4+/CD8+、CD80、CD86水平均较治疗前下降，但研究组高于对照组（P<0.05）。治疗2个疗程后，两组癌胚抗原（CEA）、糖蛋白 125（CA125）、糖蛋白 153（CA153）水平均较治疗前下降，且研究组低于对照组（P<0.05）。结论：参芪扶正注射液联合多西他赛治疗乳腺癌患者，可有效减少肿瘤标志物分泌，抑制肿瘤生长，减轻机体免疫抑制，改善外周血象，且安全可靠。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effect of Shenqi Fuzheng injection combined with docetaxel on peripheral blood picture, immune function and serum tumor markers in patients with breast cancer. Methods: 64 patients with breast cancer who were admitted to our hospital from January 2018 to December 2019 were selected, they were divided into control group (n=32, docetaxel treatment) and study group (n=32, Shenqi Fuzheng injection combined with docetaxel treatment) according to the envelope drawing method. The curative effect of the two groups was compared, the peripheral blood picture, immune function and serum tumor markers before treatment and 2 courses after treatment were compared, the adverse reactions of the two groups during the treatment were recorded. Results: There was no difference in adverse reactions between the two groups (P>0.05). 2 courses after treatment, total effective rate of control group was 43.75% (14/32), total effective rate of study group was 68.75% (22/32), the total effective rate of the study group was higher than control group (P<0.05). 2 courses after treatment, hemoglobin, platelets and white blood cells levels of the two groups decreased compared with those before treatment, but the study group was higher than the control group (P<0.05). The levels of CD3+, CD4+/CD8+, CD80, CD86 of the two groups were lower than those of before treatment, but the study group was higher than control group(P<0.05). 2 courses after treatment, levels of carcinoembryonic antigen (CEA), glycoprotein 125 (CA125) , glycoprotein 153 (CA153) of the two groups decreased compared with those of before treatment, and the study group was lower than the control group (P<0.05). Conclusion: Shenqi Fuzheng injection combined with docetaxel in the treatment of breast cancer patients, can effectively reduce the secretion of tumor markers, inhibit tumor growth, reduce immune suppression, improve peripheral blood picture, and which is safe and reliable. |
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