| 刘 欣,王 群,陶旭炜,黄砚屏,曾凌空.血清SAA、CRP、SIRT1水平与新生儿坏死性小肠结肠炎疾病进展的关系及其诊断价值分析[J].,2021,(10):1849-1853 |
| 血清SAA、CRP、SIRT1水平与新生儿坏死性小肠结肠炎疾病进展的关系及其诊断价值分析 |
| The Relationship between Serum SAA, CRP and SIRT1 Levels and the Progression of Neonatal Necrotizing Enterocolitis and Their Diagnostic Value Analysis |
| 投稿时间：2020-10-21 修订日期：2020-11-16 |
| DOI：10.13241/j.cnki.pmb.2021.10.010 |
| 中文关键词: 坏死性小肠结肠炎 新生儿 修正Bell分期 血清淀粉样蛋白A C反应蛋白 沉默信息调节因子1 |
| 英文关键词: Necrotizing enterocolitis SNewborns Cerum amyloid A orrected Bell stages C-reactive protein Silent information regulator 1 |
| 基金项目:湖北省自然科学基金项目(2016CFB752)；武汉市卫生和计划生育委员会科研项目(WX16E14) |
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| 中文摘要: |
| 摘要 目的：探讨血清淀粉样蛋白A(SAA)、C反应蛋白（CRP）、沉默信息调节因子1（SIRT1）水平与新生儿坏死性小肠结肠炎疾病进展的关系及其诊断价值。方法：选择2017年3月至2018年10月华中科技大学同济医学院附属武汉儿童医院新生儿内科诊治的100例坏死性小肠结肠炎患儿作为观察组，另选择同期在华中科技大学同济医学院附属武汉儿童医院出生的100例健康新生儿作为对照组。检测各组血清SAA、CRP、SIRT1水平。比较不同修正Bell分期患儿血清SAA、CRP、SIRT1水平。采用Spearman相关性分析观察组患儿血清SAA、CRP、SIRT1水平与修正Bell分期的相关性。采用受试者工作特征（ROC）曲线评估三项指标对坏死性小肠结肠炎的诊断价值。结果：与对照组相比，观察组血清SAA、CRP水平明显升高，而SIRT1水平明显下降（P<0.05）。不同修正Bell分期患儿血清SAA、CRP、SIRT1水平比较，经单因素方差分析，差异有统计学意义（P<0.05）。修正Bell分期Ⅰ期、Ⅱ期、Ⅲ期患儿血清SAA、CRP水平依次升高，修正Bell分期Ⅰ期、Ⅱ期、Ⅲ期患儿血清SIRT1水平依次降低（均P<0.05）。修正Bell分期与血清SAA、CRP水平呈正相关（P＜0.05），修正Bell分期与血清SIRT1水平呈负相关（P＜0.05）。ROC曲线分析结果显示，三指标联合检测诊断坏死性小肠结肠炎的曲线下面积（AUC）、敏感度、特异度和约登系数均高于三指标单独检测。结论：坏死性小肠结肠炎新生儿血清SAA、CRP水平升高，而SIRT1水平下降，且与新生儿坏死性小肠结肠炎疾病进展有关，三指标联合诊断坏死性小肠结肠炎的价值较高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum amyloid A (SAA), C-reactive protein (CRP) and silent information regulator 1 (SIRT1) levels and the progression of neonatal necrotizing enterocolitis and their diagnostic value. Methods: 100 cases of necrotizing enterocolitis treated in the neonatal department of Wuhan Children's Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology from March 2017 to October 2018 were selected as the observation group. Another 100 healthy newborns born in Wuhan Children's Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology were selected as the control group. The serum SAA, CRP and SIRT1 levels were measured in each group. Serum SAA, CRP and SIRT1 levels were compared among children with different corrected Bell stages. Spearman correlation analysis was used to observe the correlation between serum SAA, CRP and SIRT1 levels and corrected Bell staging in children in the group. The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of three indexes for necrotizing enterocolitis. Results: Compared with the control group, serum SAA and CRP levels were significantly increased in the observation group, while SIRT1 levels were significantly decreased(P<0.05). Comparison of the serum SAA, CRP and SIRT1 levels cin children with different corrected Bell stages showed statistically significant differences by one-way analysis of variance (P<0.05). The serum SAA and CRP levels of the children with corrected Bell stage I, II and III increased in turn, and the serum SIRT1 level of the children with corrected Bell stage I, II and III decreased in turn (all P<0.05). Corrected Bell staging was positively correlated with serum SAA and CRP levels(P＜0.05). Corrected Bell staging was negatively correlated with serum SIRT1 level (P＜0.05). The area under curve (AUC) value, sensitivity, specificity and Youden index of the combined detection of three indexes were higher than those of the three indexes alone. Conclusion: The serum SAA and CRP levels in newborns with necrotizing enterocolitis are increased, while the SIRT1 level is decreased, which are related to the progression of neonatal necrotizing enterocolitis. The combined value of the three indexes in the diagnosis of necrotizing enterocolitis is relatively high. |
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