| 杨镇帆,王世广,赵 玲,赵宾彦,刘裔荣,王 迪.针刺联合明目地黄丸对干眼症患者眼表功能、生活质量和血清炎症因子的影响[J].,2021,(9):1755-1758 |
| 针刺联合明目地黄丸对干眼症患者眼表功能、生活质量和血清炎症因子的影响 |
| Effects of Acupuncture Combined with Mingmu Dihuang Pill on Ocular Surface Function, Quality of Life and Serum Inflammatory Factors in Patients with Dry Eye |
| 投稿时间：2021-01-02 修订日期：2021-01-24 |
| DOI：10.13241/j.cnki.pmb.2021.09.034 |
| 中文关键词: 针刺 明目地黄丸 干眼症 眼表功能 生活质量 炎症因子 |
| 英文关键词: Acupuncture Mingmu Dihuang Pill Dry eye Ocular surface function Quality of life Inflammatory factors |
| 基金项目:中国中医科学院"十三五"第一批重点领域科研项目（ZZ10-012）；北京中医医院顺义医院院级课题（SYYJ-201808） |
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| 中文摘要: |
| 摘要 目的：探讨针刺联合明目地黄丸对干眼症患者眼表功能、生活质量和血清炎症因子的影响。方法：选择我院2019年5月~2020年12月期间收治的干眼症患者84例。依据随机数字表法将患者分为对照组（n=42，常规西医治疗）和研究组（n=42，在对照组基础上联合针刺与明目地黄丸治疗），两组均治疗8周。对比两组治疗8周后的疗效，对比两组治疗前、治疗8周后的眼表功能、生活质量及血清炎症因子变化情况。结果：治疗8周后，研究组的临床总有效率较对照组高（P<0.05）。治疗8周后，两组眼表疾病指数（OSDI）、角膜荧光素染色（FL）评分较治疗前下降，且研究组低于对照组（P<0.05），治疗8周后，两组Schirmer I试验结果（SIT）、泪膜破裂时间（BUT）较治疗前升高或延长，且研究组高或长于对照组（P<0.05）。治疗8周后，两组转化生长因子-β（TGF-β）、肿瘤坏死因子-α（TNF-α）和白介素-1（IL-1）较治疗前下降，且研究组低于对照组（P<0.05）。治疗8周后，两组SF-36各维度评分较治疗前升高，且研究组高于对照组（P<0.05）。结论：干眼症患者经针刺联合明目地黄丸治疗后，症状得到显著改善，可有效提高患者生活质量，其主要作用机制可能与调节机体炎症反应有关。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the effect of acupuncture combined with Mingmu Dihuang Pills on ocular surface function, quality of life and serum inflammatory factors in patients with dry eye. Methods: 84 patients with dry eye in our hospital from May 2019 to December 2020 were selected. According to the random number table method, the patients were divided into control group (n=42, conventional western medicine treatment) and study group (n=42, acupuncture combined with Mingmu Dihuang Pill treatment on the basis of control group), both groups were treated for 8 weeks. The curative effect of the two groups at 8 weeks after treatment was compared, and the changes of ocular surface function, quality of life and serum inflammatory factors before and 8 weeks after treatment were compared. Results: 8 weeks after treatment, the total effective rate of the study group was higher than that of the control group (P<0.05). 8 weeks after treatment, ocular surface disease index(OSDI)and corneal fluorescein staining (FL) scores of the two groups decreased compared with those before treatment, and the study group was lower than the control group (P<0.05). 8 weeks after treatment, Schirmer I test results (SIT), tear film break-up time (BUT) of the two groups increased or prolonged compared with those before treatment, and the study group was higher or longer than the control group(P<0.05). 8 weeks after treatment, the transforming growth factor-β (TGF-β), tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1) of the two groups decreased compared with those before treatment, and the study group was lower than the control group (P<0.05). 8 weeks after treatment, SF-36 dimensions scores of the two groups were higher than those before treatment, and the study group was higher than the control group (P<0.05). Conclusion: After acupuncture combined with Mingmu Dihuang Pill, the symptoms of patients with dry eye can be significantly improved, which can effectively improve the quality of life of patients. Its main mechanism may be related to the regulation of inflammatory reaction. |
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