| 冯芜若,许 莹,虞文魁,吴 婷,李 静.急性缺血性脑卒中患者血清miR-124、 miR-134表达与病情严重程度及炎症反应的关系研究[J].,2021,(9):1751-1754 |
| 急性缺血性脑卒中患者血清miR-124、 miR-134表达与病情严重程度及炎症反应的关系研究 |
| Relationship between Serum miR-124 and miR-134 Expression and Severity of Disease and Inflammatory Response in Patients with Acute Ischemic Stroke |
| 投稿时间：2020-12-27 修订日期：2021-01-23 |
| DOI：10.13241/j.cnki.pmb.2021.09.033 |
| 中文关键词: 急性缺血性脑卒中 miR-124 miR-134 表达 病情 炎症反应 |
| 英文关键词: Acute ischemic stroke miR-124 miR-134 Express Severity of disease Inflammatory response |
| 基金项目:国家自然科学基金项目（8180080852） |
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| 中文摘要: |
| 摘要 目的：探讨急性缺血性脑卒中（AIS）患者血清微小RNA-124（miR-124）、微小RNA-134（miR-134）表达与病情严重程度及炎症反应的关系。方法：选择我院2018年10月~2019年10月进行治疗的90例AIS患者作为观察组，另选取同时期来我院进行健康体检的志愿者90例作为对照组。观察组患者根据梗死体积的大小分为大梗死体积组（梗死体积＞3 cm3）和小梗死体积组（梗死体积≤3 cm3），根据美国国立卫生研究院卒中量表（NIHSS评分）分为中重度卒中组（NIHSS评分＞5分）和轻度卒中组（NIHSS评分≤5分）。比较观察组与对照组血清miR-124、miR-134及膜辅蛋白（MCP）、C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）、白细胞介素-12（IL-12）、白细胞介素-35（IL-35）水平，比较不同梗死体积和不同NIHSS评分AIS患者血清miR-124、miR-134、MCP、CRP、TNF-α、IL-12、IL-35水平，分析观察组血清miR-124、miR-134与梗死体积、NIHSS评分及上述血清炎症因子的相关性。结果：观察组患者的血清miR-124、miR-134、MCP、CRP、TNF-α、IL-12、IL-35水平均高于对照组（P＜0.05）；大体积梗死组血清miR-124、miR-134水平高于小体积梗死组（P＜0.05）。中重度卒中组患者血清miR-124、miR-134水平高于轻度卒中组（P＜0.05）。经Pearson相关性分析显示，观察组患者血清miR-124、miR-134水平与梗死体积、NIHSS评分及MCP、CRP、TNF-α、IL-12、IL-35均呈正相关（P＜0.05）。结论：AIS患者血清miR-124、miR-134水平异常升高，且与梗死体积、病情严重程度及炎症反应程度呈正相关，检测血清miR-124、 miR-134有助于评估AIS患者病情。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum miR-124 and miR-134 expression and severity of disease and inflammatory response in patients with acute ischemic stroke. Methods: 90 patients with AIS who were treated in our hospital from October 2018 to October 2019 were selected as the observation group.In addition, 90 volunteers who came to our hospital for physical examination during the same period were selected as the control group. Patients in the observation group were divided into large infarct volume group (infarct volume > cm3) and small infarct volume group (infarct volume ≤3 cm3) according to the size of the infarct volume. Patients in the observation group were divided into moderate and severe stroke group (NIHSS score > 5 scores) and mild stroke group (NIHSS score ≤5 scores) according to the national institutes of health stroke scale (NIHSS score). Serum miR-124, miR-134, membrane coprotein (MCP), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-12 (IL-12), and interleukin-35 (IL-35) levels were compared between the observation group and the control group. Serum miR-124, miR-134, MCP, CRP, TNF-α, IL-12, and IL-35 levels in AIS patients with different infarction volumes and different NIHSS scores were compared. The correlation between serum miR-124 and miR-134 and infarction volume, NIHSS score and the above serum inflammatory factors in the observation group was analyzed. Results: The serum miR-124, miR-134, MCP, CRP, TNF-α, IL-12 and IL-35 levels in the observation group were all higher than those in the control group (P<0.05). The serum miR-124 and miR-134 levels in the large-volume infarction group were higher than those in the small-volume infarction group (P<0.05). The serum miR-124 and miR-134 levels in patients with moderate and severe stroke were higher than those in patients with mild stroke (P<0.05). Pearson correlation analysis showed that serum miR-124 and miR-134 levels in the observation group were positively correlated with infarction volume, NIHSS score, MCP, CRP, TNF-α, IL-12 and IL-35 (P<0.05). Conclusion: The serum miR-124 and miR-134 levels in patients with AIS are abnormally elevated, and they are positively correlated with the volume of infarction, severity of disease and degree of inflammatory response. The detection of serum miR-124 and miR-134 is helpful to evaluate the condition of patients with AIS. |
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