| 阿小英,甘 芳,李 琴,朵红梅,李娟娟.桂枝茯苓胶囊对慢性盆腔炎大鼠粘连修复相关指标、免疫功能及肿瘤坏死因子-α、白细胞介素-2的影响[J].,2021,(9):1639-1643 |
| 桂枝茯苓胶囊对慢性盆腔炎大鼠粘连修复相关指标、免疫功能及肿瘤坏死因子-α、白细胞介素-2的影响 |
| Effects of Guizhi Fuling Capsule on Adhesion Repair Indexes, Immune Function, Tumor Necrosis Factor-α and Interleukin-2 in Rats with Chronic Pelvic Inflammation Disease |
| 投稿时间：2020-11-12 修订日期：2020-12-07 |
| DOI：10.13241/j.cnki.pmb.2021.09.008 |
| 中文关键词: 桂枝茯苓胶囊 慢性盆腔炎 大鼠 子宫内膜病变 免疫功能 肿瘤坏死因子-α 白细胞介素-2 |
| 英文关键词: Guizhi Fuling capsule Chronic pelvic inflammation disease Rats Endometrial lesions Immune function Tumor necrosis factor-α Interleukin-2 |
| 基金项目:青海省科技厅基金项目（2018-ZJ-711） |
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| 摘要 目的：研究桂枝茯苓胶囊对慢性盆腔炎（CPID）大鼠粘连修复相关指标、免疫功能及肿瘤坏死因子-α（TNF-α）、白细胞介素-2（IL-2）的影响。方法：选择SD清洁级雌性大鼠60只，根据随机数字表法将其分成6组，每组10只，分别为对照组、假手术组、模型组、高剂量组（给药剂量为2.0 g/kg）、中剂量组（给药剂量为1.0g/kg）、低剂量组（给药剂量为0.5 g/kg）。造模后，对照组和假手术组及模型组均予以蒸馏水灌胃，1次/d，剂量为1 mL/100 g，各剂量组均根据相应剂量的桂枝茯苓胶囊灌胃，1次/d。对比各组大鼠粘连修复相关指标[转化生长因子-β1（TGF-β1）和血管内皮生长因子（VEGF）]、免疫指标[红细胞C3b受体花环率、免疫复合物花环率、免疫球蛋白A(IgA)、IgG、IgM]、TNF-α、IL-2水平及子宫内膜病变情况。结果：造模后，各剂量组、对照组和假手术组红细胞C3b受体花环率、IL-2、IgA、IgG和IgM水平均明显高于模型组，但各剂量组IgA、IgG和IgM水平仍低于对照组和假手术组（均P＜0.05）；各剂量组、对照组和假手术组免疫复合物花环率、TNF-α、病理综合评分、TGF-β1和VEGF水平均明显低于模型组，但各剂量组病理综合评分、TGF-β1和VEGF水平仍高于对照组和假手术组（均P＜0.05）。结论：桂枝茯苓胶囊治疗CPID可能与其抑制炎症水平、促进粘连修复、提升免疫功能有关。 |
| 英文摘要: |
| ABSTRACT Objective: To study the effects of Guizhi Fuling capsule on the adhesion repair indexes, immune function, tumor necrosis factor-α (TNF-α) and interleukin-2 (IL-2) in rats with chronic pelvic inflammatory disease (CPID). Methods: 60 SD clean grade female rats were selected, and they were divided into 6 groups according to the random number table method, with 10 rats in each group, namely the control group, the sham operation group, the model group, the high dose group (the dose was 2.0 g/kg), the medium dose group (the dose was 1.0 g/kg) and the low dose group (the dose was 0.5 g/kg). After modeling, the control group, the sham operation group and the model group were all given distilled water gavage, 1 times/d, at the dose of 1 mL/100 g, and each dose group was gavage with the corresponding dose of Guizhi Fuling capsule 1 times/d. The adhesion repair indexes [transforming growth factor-β1(TGF-β1) and vascular endothelial growth factor (VEGF)], immune indexes [red blood cells C3b receptor garland rate, immune complex garland rate, immunoglobulin A(IgA), IgG, IgM], TNF-α, IL-2 levels and endometrial lesions in each group were compared. Results: After modeling, red blood cells C3b receptor garland rate, IL-2, IgA, IgG and IgM levels in each dose group, the control group and the sham operation group were significantly higher than those in the model group, but the IgA, IgG and IgM levels in each dose group were still lower than those in the control group and sham operation group (all P＜0.05). The immune complex garland rate, TNF-α, pathological composite score, TGF-β1 and VEGF levels in each dose group, the control group and the sham operation group were significantly lower than those in the model group, but the pathological composite score, TGF-β1 and VEGF levels in each dose group were still higher than those in the control group and the sham operation group (all P＜0.05). Conclusion: The treatment of CPID with Guizhi Fuling capsule may be related to the inhibition of inflammation levels, the promotion of adhesion repair and the improvement of immune function. |
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