| 杨贤科,钱 浓,彭先波,潘 兴,马 妮.杏芎氯化钠注射液联合依达拉奉对急性脑梗死患者神经功能、脑血流灌注及氧化应激水平的影响[J].,2021,(7):1374-1378 |
| 杏芎氯化钠注射液联合依达拉奉对急性脑梗死患者神经功能、脑血流灌注及氧化应激水平的影响 |
| Effects of Xingxiong Sodium Chloride Injection Combined with Edaravone on Neurological Function, Cerebral Blood Perfusion and Oxidative Stress in Patients with Acute Cerebral Infarction |
| 投稿时间：2020-07-25 修订日期：2020-08-21 |
| DOI：10.13241/j.cnki.pmb.2021.07.038 |
| 中文关键词: 杏芎氯化钠注射液 依达拉奉 急性脑梗死 神经功能 脑血流灌注 氧化应 |
| 英文关键词: Xingxiong sodium chloride injection Edaravone Acute cerebral infarction Neurological function Cerebral perfusion Oxidative stress |
| 基金项目:国家自然科学基金项目（81270337）；陕西省卫生厅科研基金项目（2015JM40361） |
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| 中文摘要: |
| 摘要 目的：探讨杏芎氯化钠注射液联合依达拉奉对急性脑梗死（ACI）患者神经功能、脑血流灌注及氧化应激水平的影响。方法：随机将2018年1月至2019年7月我院收治的120例ACI患者分为两组，均给予常规神经内科治疗，对照组（60例）在常规治疗基础上给予依达拉奉静脉滴注2周，观察组（60例）在对照组基础上加用杏芎氯化钠注射液滴注两周。观察两组临床疗效和安全性，并比较治疗前后神经功能、认知功能、残疾程度、脑血流灌注以及氧化应激水平的差异。结果：观察组治疗总有效率均高于对照组（P＜0.05）。观察组治疗后美国国立研究院脑卒中评定量表（NIHSS）、改良RANKIN量表（MRS）评分、脑缺血区平均通过时间(MTT)、峰值时间 (TTP)、丙二醛(MDA)、晚期氧化蛋白产物(AOPP)低于对照组（P＜0.05），简易智能精神状态检查量表(MMSE)评分、脑血流量(CBF)、脑血容量(CBV)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、总抗氧化能力(T-AOC )高于对照组（P＜0.05）。两组不良反应率比较无统计学差异（P＞0.05）。结论：杏芎氯化钠注射液联合依达拉奉治疗可有效地改善ACI患者神经功能，增加缺血区脑血流灌注量，改善氧化应激，提高临床疗效。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of Xingxiong sodium chloride injection combined with edaravone on neurological function, cerebral blood perfusion and oxidative stress in patients with acute cerebral infarction (ACI). Methods: 120 patients with ACI who were admitted to our hospital from January 2018 to July 2019 were randomly divided into two groups, all of which were given conventional neurology treatment. The control group (60 cases) received edaravone intravenous infusion for 2 weeks on the basis of conventional treatment, and the observation group (60 cases) received Xingxiong sodium chloride injection for 2 weeks on the basis of the control group. The clinical efficacy and safety of the two groups were observed, and the differences in neurological functions, cognitive functions, handicapped degree, cerebral blood perfusion, and oxidative stress levels before and after treatment were compared. Results: The total effective rate in the observation group were higher than that in the control group (P<0.05). After treatment, National Institute of Health stoke scale (NIHSS), Modified RANKIN scale (MRS) scores, mean transit time (MTT), time to peak (TTP), serum malondialdehyde (MDA) and advanced oxidation protein products (AOPP) in the observation group were lower than those in the control group (P<0.05), and Mini-Mental State Examination (MMSE) score, cerebral blood flow(CBF), cerebral blood volume (CBV) , serum uperoxide distamuse (SOD), glutathione peroxidase (GSH-Px) and total anti-oxidation capacity (T-AOC) were higher than those in the control group (P<0.05). There was no statistically significant difference in adverse reaction rates between the two groups (P>0.05). Conclusion: Xingxiong sodium chloride injection combined with edaravone can effectively improve the neurological function of patients with ACI, it can increase cerebral blood perfusion in ischemic areas, improve the oxidative stress, and it can improve clinical efficacy. |
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