| 奉 娅,肖 祥,周 萍,罗 丽,王少清.肾病综合征患者血浆leptin、IL-4、IL-18及TNF-α水平变化及其临床意义[J].,2021,(7):1338-1341 |
| 肾病综合征患者血浆leptin、IL-4、IL-18及TNF-α水平变化及其临床意义 |
| Changes in Plasma Leptin, IL-4, IL-18 and TNF-α Levels in Patients with Nephrotic Syndrome and Their Clinical Significanc |
| 投稿时间：2020-07-07 修订日期：2020-07-31 |
| DOI：10.13241/j.cnki.pmb.2021.07.030 |
| 中文关键词: 肾病综合征 瘦素 白介素-4 白介素-18 肿瘤坏死因子-α 24h蛋白尿 血浆白蛋白 |
| 英文关键词: Nephrotic syndrome Leptin Interleukin-4 Interleukin-18 Tumor necrosis factor-α 24h proteinuria Plasma albumin |
| 基金项目:国家自然科学基金项目（81170667）；四川养老与老年健康协同创新中心2016年度招标课题（YLZBZ1510） |
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| 中文摘要: |
| 摘要 目的：探究肾病综合征患者血浆瘦素（leptin）、白介素-4（IL-4）、白介素-18（IL-18）及肿瘤坏死因子-α（TNF-α）水平变化及其临床意义。方法：选择2018年2月至2019年10月我院诊治的110例肾病综合征患者作为观察组，选择同期在我院体检的110名健康者作为对照组。检测并比较两组的血浆leptin、IL-4、IL-18、TNF-α水平及24 h蛋白尿、血浆白蛋白水平，采用Pearson法分析血浆leptin、IL-4、IL-18和TNF-α与24 h蛋白尿、血浆白蛋白的相关性，采用受试者工作特征曲线（ROC）分析各指标对肾病综合征的诊断价值。结果：与对照组相比，观察组的血浆leptin、IL-4、IL-18及TNF-α水平明显升高（P<0.05）。与对照组相比，观察组的24 h蛋白尿明显升高，血浆白蛋白水平明显下降（P<0.05）。血浆leptin、IL-4、IL-18和TNF-α水平与24 h蛋白尿均呈正相关性，而与血浆白蛋白均呈负相关性（P<0.05）。血浆leptin、IL-4、IL-18和TNF-α联合检测对肾病综合征的诊断价值明显高于各项指标单独检测。结论：肾病综合征患者血浆leptin及炎症因子水平明显升高，并且与患者24h蛋白尿以及血浆白蛋白具有相关性，血浆leptin和IL-4、IL-18、TNF-α联合检测对肾病综合征具有较高的诊断价值。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the changes of plasma leptin, interleukin-4 (IL-4), interleukin-18 (IL-18) and tumor necrosis factor - α (TNF-α) levels in patients with nephrotic syndrome and their clinical significance. Methods: 110 cases of nephrotic syndrome diagnosed and treated in our hospital from February 2018 to October 2019 were selected as the observation group, and 110 healthy patients who underwent physical examination in our hospital during the same period were selected as the control group. The plasma leptin, IL-4, IL-18, TNF-α, 24 h proteinuria and plasma albumin levels were measured and compared between the two groups. The correlation of plasma leptin, IL-4, IL-18 and TNF-α with 24 h proteinuria and plasma albumin were analyzed by Pearson method. The diagnostic value of each index to nephrotic syndrome was analyzed by receiver operating characteristic curve (ROC). Results: Compared with the control group, the plasma leptin, IL-4, IL-18 and TNF-α levels in the observation group were significantly increased (P<0.05). Compared with the control group, 24 h proteinuria in the observation group was significantly increased, and plasma albumin level was significantly decreased (P<0.05). The plasma leptin, IL-4, IL-18 and TNF-α levels were positively correlated with 24 h proteinuria, while negatively correlated with plasma albumin (P<0.05). The diagnostic value of plasma leptin, IL-4, IL-18 and TNF-α in the combined diagnosis of nephrotic syndrome was significantly higher than that of single diagnosis of plasma leptin, IL-4, IL-18 and TNF-α. Conclusion: The plasma leptin and inflammatory cytokines levels are significantly increased in patients with nephrotic syndrome, which are correlated with the patients' 24 h proteinuria and plasma albumin. The combined detection of plasma leptin , IL-4, IL-18 and TNF-α is of high diagnostic value for nephrotic syndrome. |
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