| 刘 涛,曹文兰,吴显文,刘 宇,杨太峰.三维适形调强放疗联合榄香烯注射液对食管癌患者血清肿瘤标志物和T淋巴细胞亚群的影响[J].,2021,(7):1253-1256 |
| 三维适形调强放疗联合榄香烯注射液对食管癌患者血清肿瘤标志物和T淋巴细胞亚群的影响 |
| Effect of Three-dimensional Conformal Intensity-modulated Radiotherapy Combined with Elemene Injection on Serum Tumor Markers and T-lymphocyte Subsets in Patients with Esophageal Cancer |
| 投稿时间：2020-07-26 修订日期：2020-08-22 |
| DOI：10.13241/j.cnki.pmb.2021.07.011 |
| 中文关键词: 三维适形调强放疗 榄香烯注射液 食管癌 肿瘤标志物 T淋巴细胞亚群 |
| 英文关键词: Three-imensional conformal intensity-modulated radiotherapy Elemene injection Esophageal cancer Tumor markers T-lymphocyte subsets |
| 基金项目:北京市科技计划项目（Z161100001616058） |
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| 中文摘要: |
| 摘要 目的：探讨三维适形调强放疗联合榄香烯注射液对食管癌患者血清肿瘤标志物和T淋巴细胞亚群的影响。方法：选取我院于2016年8月到2019年12月期间接诊的食管癌患者60例，根据随机数字表法分为对照组（n=30）和研究组（n=30），对照组患者予以三维适形调强放疗，研究组在对照组基础上联合榄香烯注射液治疗，比较两组患者疗效、生存质量、血清肿瘤标志物、T淋巴细胞亚群以及不良反应。结果：研究组患者治疗6周后的临床总有效率为63.33%（19/30），高于对照组患者的36.67%（11/30）（P<0.05）。两组治疗6周后血清癌胚抗原（CEA）、糖类抗原199（CA199）水平均较治疗前降低，且研究组低于对照组（P<0.05）。两组患者治疗6周后CD3+、CD4+、CD4+/CD8+水平均下降，但研究组高于对照组（P<0.05），CD8+水平均升高，但研究组低于对照组（P<0.05）。两组治疗6周后卡劳夫斯基（KPS）评分均较治疗前升高，且研究组高于对照组（P<0.05）。两组不良反应发生率对比未见统计学差异（P>0.05）。结论：三维适形调强放疗联合榄香烯注射液治疗食管癌患者，疗效较好，可有效阻止疾病进展，改善患者生存质量和降低血清肿瘤标志物水平，减轻机体免疫抑制，且不增加不良反应发生率。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of three-dimensional conformal intensity-modulated radiotherapy combined with elemene injection on serum tumor markers and T-lymphocyte subsets in patients with esophageal cancer. Methods: 60 patients with esophageal cancer who were admitted to our hospital from August 2016 to December 2019 were selected, patients were divided into control group (n=30) and study group (n=30) according to the random number table. Patients in the control group were treated with three-dimensional conformal intensity-modulated radiotherapy. The study group was treated with elemene injection on the basis of the control group, and the efficacy, quality of life, serum tumor markers, T-lymphocyte subsets and adverse reactions of the two groups were compared. Results: The total clinical effective rate of the study group at 6 weeks after treatment was 63.33% (19/30), which was higher than 36.67% (11/30) of the control group (P<0.05). The levels of serum carcinoembryonic antigen (CEA), carbohydrate antigen-199 (CA199) in the two groups at 6 weeks after treatment were lower than those before treatment, and those in the study were lower than those in the control group (P<0.05). The levels of CD3+, CD4+, CD4+ / CD8+ in both groups at 6 weeks after treatment decreased, but those in the study group were higher than those in the control group (P<0.05), and the levels of CD8+ increased, but that in the study group was lower than that in the control group (P<0.05). 6 weeks after treatment, the score of Karnofsky (KPS) in the two groups were higher than that before treatment, and that in the study group was higher than that in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Three-dimensional conformal intensity-modulated radiotherapy combined with elemene injection has a good effect on the treatment of esophageal cancer. It can effectively prevent the progression of the disease, improve the quality of life of the patients and reduce the level of serum tumor markers, reduce the immunosuppression of the body, and do not increase the incidence of adverse reactions. |
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