| 宫 瑞,蒋红梅,孙 广,于明瑞,岳龙飞,张云东.502例丙型肝炎患者病毒基因分型及与性别和年龄的关系研究[J].,2021,(6):1147-1150 |
| 502例丙型肝炎患者病毒基因分型及与性别和年龄的关系研究 |
| Genotyping of Hepatitis C Virus in 502 Patients and Its Relationship with Gender and Age |
| 投稿时间：2020-08-23 修订日期：2020-09-17 |
| DOI：10.13241/j.cnki.pmb.2021.06.033 |
| 中文关键词: 丙型肝炎病毒 基因型 PCR-荧光探针法 贵州 性别 年龄 |
| 英文关键词: Hepatitis C virus Genotype PCR fluorescence probe Guizhou Gender Age |
| 基金项目:国家自然科学基金地区科学基金项目（81960393）；安顺市科技计划项目（安市科社[2019] 05号） |
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| 中文摘要: |
| 摘要 目的：探讨502例丙型肝炎患者病毒基因分型的情况，分析其与性别和年龄的关系，为丙型肝炎的防治提供参考。方法：收集贵州地区502例丙型肝炎患者的血液标本，采用PCR-荧光探针法检测丙型肝炎病毒基因型，并对检测数据进行统计学分析。结果：共检出4种基因型及5种基因亚型，主要以1b型、3b型为主，其次是6a、3a型，2a型较少。不同性别丙型肝炎病毒（HCV）基因型分布比较，差异有统计学意义（x2=11.029，P=0.026），男、女性患者均以1b 型、3b型为主要基因型，但男性感染者明显多于女性。各个年龄组HCV基因型分布比较，差异有统计学意义（x2=102.946，P=0.000），40-59岁组感染者最多，以1b型为主，其次是20-39岁组，以3b型为主，≥60岁组感染人数较少，以1b型为主。结论：贵州地区HCV呈现多基因型分布，1b、3b型为主要流行基因型，6a、3a型次之，其余基因型较少，不同性别、年龄的HCV基因型分布存在差异性。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the genotyping of hepatitis C virus in 502 patients, and analyze its relationship with gender and age, so as to provide reference for the prevention and treatment of hepatitis C. Methods: The blood samples of 502 patients with hepatitis C in Guizhou Province were collected. The genotypes of hepatitis C virus were detected by PCR fluorescence probe method, and the data were analyzed statistically. Results: 4 genotypes and 5 subgenotypes were detected, the main genotypes were 1b type and 3b type, followed by 6a and 3a types, and 2a type was less. The genotype distribution of hepatitis C virus (HCV) in different gender was statistically significant (x2=11.029, P=0.026). 1b type and 3b type were the main genotypes in both male and female patients, but the number of male patients was significantly more than that of female patients. There was significant difference in the distribution of HCV genotypes among different age groups (x2=102.946, P=0.000). The 40-59-year-old group was the most infected, mainly with 1b type, followed by 20-39-year-old group, mainly with 3b type, and the ≥60 year-old group was the least infected, mainly with 1b type. Conclusion: The distribution of HCV genotypes in Guizhou was multi genotype, 1b and 3b types were the main prevalent genotypes, followed by 6a and 3a types, and the rest were less. There were differences in the distribution of HCV genotypes in different gender and age. |
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