| 许子度,张海峰,张博晴,丁 红,杨 昀.急性心肌梗死患者血清外连素、MEG3、HSP-70水平与心肌损伤标志物及心血管不良事件的关系研究[J].,2021,(6):1134-1137 |
| 急性心肌梗死患者血清外连素、MEG3、HSP-70水平与心肌损伤标志物及心血管不良事件的关系研究 |
| Study the Relationship between Serum Exonectin, MEG3, HSP-70 Levels and Myocardial Injury Markers and Cardiovascular Adverse Events in Patients with Acute Myocardial Infarction |
| 投稿时间：2020-09-06 修订日期：2020-09-28 |
| DOI：10.13241/j.cnki.pmb.2021.06.030 |
| 中文关键词: 急性心肌梗死 外连素 MEG3 HSP-70 心肌损伤标志物 心血管不良事件 关系 |
| 英文关键词: Acute myocardial infarction Exonectin MEG3 HSP-70 Myocardial injury markers Cardiovascular adverse events Relationship |
| 基金项目:江苏省卫生和计划生育委员会医学科研项目（H201779） |
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| 中文摘要: |
| 摘要 目的：研究急性心肌梗死（AMI）患者血清外连素、母系表达基因3（MEG3）、热休克蛋白70（HSP-70）水平与心肌损伤标志物及心血管不良事件的关系。方法：选取2015年1月-2020年1月期间我院接受治疗的AMI患者200例作为AMI组，另选取同期在我院健康体检的人群100例作为对照组，对比对照组、AMI组心肌型肌酸激酶同工酶（CK-MB）、肌红蛋白（Myo）、心肌肌钙蛋白Ⅰ（cTnI）、外连素、MEG3 RNA、HSP-70。对比心血管不良事件与非心血管不良事件患者的CK-MB、Myo、cTnI、外连素、MEG3 RNA、HSP-70水平。采用Pearson相关性分析AMI患者血清外连素、MEG3 RNA、HSP-70水平与心肌损伤标志物的关系。结果：AMI组CK-MB、Myo、cTnI、外连素、MEG3 RNA、HSP-70均高于对照组（P<0.05）。随访过程中，有59例发生心血管不良事件纳为心血管不良事件组，剩余141例未发生心血管不良事件纳为非心血管不良事件组。心血管不良事件组患者的CK-MB、Myo、cTnI、外连素、MEG3 RNA、HSP-70均高于非心血管不良事件组（P<0.05）。AMI患者外连素、MEG3 RNA、HSP-70水平与CK-MB、Myo、cTnI均呈正相关（P<0.05）。结论：AMI患者中外连素、MEG3 RNA、HSP-70均呈现异常高表达，且与心肌损伤标志物密切相关，可考虑作为AMI患者早期确诊的新型标志物。 |
| 英文摘要: |
| ABSTRACT Objective: To study the relationship between the serum exonectin, matrilineal expression gene 3 (MEG3), heat shock protein 70 (HSP-70) levels and myocardial injury markers and cardiovascular adverse events in patients with acute myocardial infarction (AMI). Methods: 200 patients with AMI who were treated in our hospital from January 2015 to January 2020 were selected as AMI group, and another 100 cases of healthy people undergoing physical examination in our hospital during the same period were selected as the control group. The myocardial creatine kinase isoenzyme (CK-MB), myoglobin (Myo), cardiac troponin I (cTnI), exonectin, MEG3 RNA and HSP-70 were compared between control group and AMI group. CK-MB, Myo, cTnI, exonectin, MEG3 RNA and HSP-70 levels in patients with and without cardiovascular adverse events were compared. Pearson correlation was used to analyze the relationship between serum exonectin, MEG3 RNA, HSP-70 levels and myocardial injury markers in patients with AMI. Results: CK-MB, Myo, cTnI, exonectin, MEG3 RNA and HSP-70 in AMI group were higher than those in control group (P<0.05). During the follow-up, 59 cases with cardiovascular adverse events were included in the cardiovascular adverse events group, and the remaining 141 cases without cardiovascular adverse events were included in the non cardiovascular adverse events group. The CK-MB, Myo, cTnI, exonectin, MEG3 RNA and HSP-70 in cardiovascular adverse event group were higher than those in non cardiovascular adverse event group (P<0.05). The exonectin, MEG3 RNA and HSP-70 in AMI patients were positively correlated with CK-MB, Myo and cTnI (P<0.05). Conclusion: The expression of exonectin, MEG3 RNA and HSP-70 in patients with AMI are abnormally high, and they are closely related to myocardial injury markers, which can be considered as a new marker for early diagnosis of AMI. |
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