| 柏志芳,刘 霞,宗淑芳,于瑞莲,马 倩.毫火针联合补肾活血方对寻常型白癜风患者外周血炎性因子和免疫指标的影响[J].,2021,(4):702-705 |
| 毫火针联合补肾活血方对寻常型白癜风患者外周血炎性因子和免疫指标的影响 |
| The Influence of the Combination of the Prescription of Nourishing the Kidney and Activating the Blood on the Inflammatory Factors and Immune Indexes in the Peripheral Blood of Vitiligo Vulgaris |
| 投稿时间：2020-05-30 修订日期：2020-06-24 |
| DOI：10.13241/j.cnki.pmb.2021.04.021 |
| 中文关键词: 毫火针 补肾活血方 白癜风 炎性因子 免疫指标 |
| 英文关键词: Milli fire acupuncture Bushen Huoxue Formula Vitiligo vulgaris Inflammatory factors Immune indicators |
| 基金项目:江苏省中医药科技发展计划项目（YB201934） |
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| 中文摘要: |
| 摘要 目的：探讨毫火针联合补肾活血方对寻常型白癜风患者外周血炎性因子和免疫指标的影响。方法：选取2017年3月~2019年7月期间我院收治的寻常型白癜风患者75例，根据随机数字表法分为对照组（n=37）和观察组（n=38），对照组予以常规治疗和补肾活血方，观察组在对照组的基础上联合毫火针治疗，比较两组疗效、白癜风皮损面积、炎性因子[白介素-17（IL-17）、白介素-10（IL-10）、白介素-22（IL-22）]和免疫指标[粒细胞-巨噬细胞集落刺激因子（GM-CSF）、CD4+CD25+Treg]水平，记录两组治疗期间不良反应情况。结果：观察组治疗12周后的临床总有效率高于对照组（P<0.05）。两组白癜风皮损面积均较治疗前缩小，且观察组小于对照组（P<0.05）。两组患者治疗12周后血清IL-17、IL-22、GM-CSF水平降低，且观察组低于对照组（P<0.05）；IL-10、CD4+CD25+Treg比例水平升高，且观察组高于对照组（P<0.05）。两组不良反应发生率比较差异无统计学意义（P>0.05）。结论：毫火针联合补肾活血方治疗寻常型白癜风的疗效显著，可有效提高患者的免疫功能，抑制炎性反应，改善患者临床症状，且用药安全性较好。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of the combination of the prescription of nourishing kidney and activating blood on the inflammatory factors and immune indexes of the peripheral blood in patients with vitiligo vulgaris. Methods: 75 patients with vitiligo vulgaris admitted to our hospital from March 2017 to July 2019 were divided into control group (n=37) and observation group (n=38) according to the method of random number table. The control group was treated with routine treatment + Bushen Huoxue Formula. The observation group was treated with milli fire acupuncture on the basis of the control group. The curative effect, vitiligo skin area, inflammatory factors [IL-17] and inflammatory factors [IL-17] were compared between the two groups IL-10, IL-22 and immune indexes (GM-CSF, CD4+ CD25+ Treg) were used to record the adverse reactions during the treatment. Results: The total effective rate of the observation group after 12 weeks treatment was higher than that of the control group (P<0.05). The area of vitiligo in the two groups was smaller than that before treatment, and that in the observation group was smaller than that in the control group (P<0.05). The serum levels of IL-17, IL-22 and CD4+ CD25+ Treg were lower in the observation group than in the control group (P<0.05), and the levels of IL-10 and GM-CSF were higher in the observation group than in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: The therapeutic effect of the combination therapy is significant, it can effectively reduce the immunosuppression, reduce the level of inflammatory factors, improve the clinical symptoms of patients, and the drug safety is good. |
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