| 亢姝娇,崔丽燕,刘小宁,张立君,特日格勒.育龄期Ⅰ-Ⅱ期BOT患者PDCD5表达情况及预后分析[J].,2021,(2):360-363 |
| 育龄期Ⅰ-Ⅱ期BOT患者PDCD5表达情况及预后分析 |
| Analysis of PDCD5 Expression and Prognosis in BOT Patients of Childbearing Age Ⅰ-Ⅱ |
| 投稿时间：2020-06-04 修订日期：2020-06-28 |
| DOI：10.13241/j.cnki.pmb.2021.02.035 |
| 中文关键词: 育龄期 卵巢交界性肿瘤 程序化死亡因子5 预后 相关性 |
| 英文关键词: Childbearing age Borderline ovarian tumors Programmed death factor 5 Prognosis Correlation |
| 基金项目:内蒙古自治区卫生计生委科研计划项目（201702094） |
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| 中文摘要: |
| 摘要 目的：探讨与分析育龄期Ⅰ-Ⅱ期卵巢交界性肿瘤(borderline Ovarian Tumor，BOT)患者程序化死亡因子5(programmed cell death 5，PDCD5)表达情况及预后。方法：选取2012年1月到2020年1月在本院诊治的育龄期BOT患者98例作为研究对象，其中临床Ⅰ-Ⅱ期78例(早中期组)，Ⅲ期20例(晚期组)。取所有患者的术中病理组织标本，采用免疫组化法检测PDCD5表达情况。跟踪随访患者的预后并进行相关性分析。结果：早中期组的PDCD5表达阳性率为28.2 %，显著低于晚期组的80.0 %(P<0.05)。两组随访到2020年5月，早中期的存活率为97.4 %，显著高于晚期组的65.0 %(P<0.05)。在早中期组，Pearson分析显示随访生存与组织学分化、远端转移、PDCD5表达阳性存在相关性(P<0.05)。二元Logistic回归分析显示组织学分化、远端转移、PDCD5表达阳性都为影响患者预后生存的主要因素(P<0.05)。结论：育龄期Ⅰ-Ⅱ期BOT患者伴随有PDCD5的低表达状况，且预后相对比较好，组织学分化、远端转移、PDCD5表达阳性都为影响育龄期Ⅰ-Ⅱ期BOT患者预后生存的主要因素。 |
| 英文摘要: |
| ABSTRACT Objective: To explore and analysis the expression and prognosis of programmed cell death 5 (PDCD5) in borderline Ovarian Tumor (BOT) patients of childbearing age. Methods: From January 2012 to January 2020, 98 cases of BOT patients of childbearing age diagnosed and treated in our hospital were selected as the research objects, included 78 cases in clinical stage Ⅰ-Ⅱ (early and mid-term group) and 20 cases in stage Ⅲ (late group). Intraoperative pathological tissue samples of all patients were collected to detect the expression of PDCD5 by immunohistochemistry. Followed up the prognosis of patients and given correlation analysis. Results: The positive rates of PDCD5 expression in the early and middle group were 28.2%, which were significantly lower than that in the late group (80.0%, P<0.05). The two groups were followed up to June 2020, the early and mid-term group survival rate were 97.4%, which were significantly higher than that of the late group (65.0%, P<0.05). In the early and mid-term groups, Pearson analysis showed that follow-up survival of early and mid-term group were associated with histological differentiation, distant metastasis, and positive PDCD5 expression (P<0.05). Binary logistic regression analysis showed that histological differentiation, distant metastasis, and positive PDCD5 expression were the main factors affected the prognosis and survival of patients of the early and mid-term group(P<0.05). Conclusion: BOT patients of childbearing age Ⅰ-Ⅱ are accompanied by low expression of PDCD5, and the prognosis are relatively good. Histological differentiation, distant metastasis, and positive expression of PDCD5 are the main factors affect the prognosis of BOT patients of childbearing age factor. |
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