| 刘雅琳,曹红梅,王晓静,孙 山,田克成,常 红.玉屏风颗粒联合他克莫司胶囊对原发性肾病综合征患儿肾功能、体液免疫功能及Th1/Th2细胞平衡的影响[J].,2021,(1):184-187 |
| 玉屏风颗粒联合他克莫司胶囊对原发性肾病综合征患儿肾功能、体液免疫功能及Th1/Th2细胞平衡的影响 |
| Effect of Yupingfeng Granule Combined with Tacrolimus Capsule on Renal Function, Humoral Immune Function and Th1 / Th2 Cell Balance in Children with Primary Nephrotic Syndrome |
| 投稿时间：2020-07-17 修订日期：2020-08-13 |
| DOI：10.13241/j.cnki.pmb.2021.01.041 |
| 中文关键词: 玉屏风颗粒 他克莫司胶囊 原发性肾病综合征 肾功能 体液免疫功能 Th1/Th2细胞 |
| 英文关键词: Yupingfeng granule Tacrolimus capsule Primary nephrotic syndrome Renal function Humoral immune function |
| 基金项目:山东省科技发展计划项目（2014GSF118049） |
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| 中文摘要: |
| 摘要 目的：探讨玉屏风颗粒联合他克莫司胶囊对原发性肾病综合征（PNS）患儿肾功能、体液免疫功能及Th1/Th2细胞平衡的影响。方法：选取2017年12月~2019年12月我院接收的PNS患儿100例，根据随机数字表法将其分为观察组、对照组，各50例。对照组患儿给予他克莫司胶囊治疗，观察组给予玉屏风颗粒联合他克莫司胶囊治疗，对比两组疗效、肾功能、体液免疫功能以及Th1/Th2细胞因子水平，记录两组治疗期间不良反应发生情况。结果：观察组治疗9个月后的临床总有效率为92.00%（46/50），高于对照组的74.00%（37/50）（P<0.05）。治疗9个月后，观察组血清肌酐（Cr）、24h尿蛋白定量、尿素氮（BUN）低于对照组（P<0.05）。治疗9个月后，观察组免疫球蛋白（Ig）A、IgG、补体C3高于对照组（P<0.05）。治疗9个月后，两组IgM组间对比无统计学差异（P>0.05）。治疗9个月后，观察组白细胞介素（IL）-10较对照组高，IL-2、转化生长因子（TGF-β1）、IL-6较对照组低（P<0.05）。两组不良反应发生率比较无差异（P>0.05）。结论：PNS患儿采用玉屏风颗粒联合他克莫司胶囊治疗疗效确切，可使患儿体液免疫功能、肾功能改善，调节Th1/Th2细胞平衡，且安全性较好。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of Yupingfeng granule combined with tacrolimus capsule on renal function, humoral immune function and Th1 / Th2 cell balance in children with primary nephrotic syndrome (PNS). Methods: 100 cases of children with PNS in our hospital from December 2017 to December 2019 were selected, and they were divided into observation group and control group according to random number table method, with 50 cases in each group. The control group was treated with tacrolimus capsule, and the observation group was treated with Yupingfeng granule combined with tacrolimus capsule. The curative effect, renal function, humoral immune function and the level of Th1 / Th2 cell balance factor were compared between the two groups, and the incidence rate of adverse reactions during the treatment in the two groups was recorded. Results: 9 months after treatment, the clinical total effective rate of the observation group was 92.00% (46/50), which was higher than 74.00% (37/50) of the control group (P<0.05). 9 months after treatment, the levels of serum creatinine (Cr), 24-hour urinary protein and urea nitrogen (BUN) of the observation group were lower than those of the control group (P<0.05). 9 months after treatment, immunoglobulin (Ig)A, IgG and complement C3 of the observation group were higher than those of the control group (P<0.05). 9 months after treatment, there was no significant difference in IgM between the two groups (P>0.05). 9 months after treatment, interleukin (IL)-10 of the observation group was higher than that of the control group, while the IL-2, transforming growth factor (TGF-β1) and IL-6 of the observation group were lower than those of the control group (P<0.05). There was significant difference in the incidence rate of adverse reactions between two groups (P>0.05). Conclusion: Children with PNS use Yupingfeng granule combined with tacrolimus capsule treatment has a definite effect, it can improve the humoral immune function and renal function, regulate the balance of Th1 / Th2 cells, and the safety is good. |
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