| 张 辉,刘怀军,杨直堂,高 洁,梁腾飞,袁丁玲,李保卫,王晓敏.HER2基因突变对非小细胞肺癌临床特征及其与CT征象的相关性研究[J].,2020,(24):4646-4650 |
| HER2基因突变对非小细胞肺癌临床特征及其与CT征象的相关性研究 |
| Study on HER2 Gene Mutation in Non-small Cell Lung Cancer Clinical Characteristics and Its Correlation with CT Findings |
| 投稿时间：2020-07-07 修订日期：2020-07-30 |
| DOI：10.13241/j.cnki.pmb.2020.24.010 |
| 中文关键词: HER2基因突变 非小细胞肺癌 临床特征 CT征象 相关性 |
| 英文关键词: HER2 gene mutation Non-small cell lung cancer Clinical features CT signs The correlation |
| 基金项目:国家自然科学基金项目（81760329）；河北省卫健委基金项目（20200597，ZD20140161） |
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| 中文摘要: |
| 摘要 目的：探讨表皮生长因子受体2（human epidermal growth factor receptor2, HER2）基因突变对非小细胞肺癌临床特征及其与CT征象的相关性。方法：回顾性选择我院2010年1月至2019年12月收治的351例非小细胞肺癌患者，收集351例非小细胞肺癌患者的HER2突变位点、CT影像学征象、一般资料等资料。分析351例患者中的HER2基因突变发生情况；单因素、多因素分析HER2突变情况与非小细胞肺癌患者的临床病理特征、CT表现特征相关性。结果：351例患者中，基因突变者20例，占比为5.70 %（20/351）。单因素结果表明，非小细胞肺癌患者中，HER2基因突变与有家族史有关（P<0.05）。病灶边界分叶/毛刺、有坏死征、胸膜凹陷征与HER2基因突变存在相关性（P<0.05）。多因素结果表明，有家族史、病灶边界分叶/毛刺、有坏死征、胸膜凹陷征是HER2基因突变的危险因素（P<0.05）。结论：有家族史、病灶边界分叶/毛刺、有坏死征、胸膜凹陷征与HER2基因突变有关，对指导临床治疗有重要意义。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical features of HER2 gene mutation in non-small cell lung cancer and its correlation with CT findings. Methods: A total of 351 patients with non-small cell lung cancer, who were admitted to Affiliated Hospital of Hebei University of Engineering from January 2010 to December 2019, were retrospectively selected. HER2 mutation sites, CT imaging signs and general data of 351 cases of non-small cell lung cancer were collected. The mutation of HER2 gene in 351 patients was analyzed. The correlation of HER2 mutation with clinicopathological characteristics and CT features of patients with non-small cell lung cancer was analysed by single-factor and multi-factor analysis. Results: In 351 patients, 20 patients had gene mutation, accounting for 5.70 % (20/351). Univariate results showed that HER2 gene mutation was associated with family history in NSCLC patients (P<0.05). There was correlation between the boundary lobules/burrs, signs of necrosis, and pleural pitting signs with HER2 gene mutation (P<0.05). The multivariate results showed that family history, focal boundary lobules/burrs, necrotic sign, and pleural pitting sign were risk factors for HER2 gene mutation (P<0.05). Conclusion: HER2 gene mutation is associated with family history, lesion boundary lobules/burr, necrotic sign and pleural pitting sign, which is of great significance for guiding clinical treatment. |
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