| 邓 宇,陈旭源,李 想,屠以诺,吴 旭.食管癌组织人端粒酶反转录酶、肿瘤转移相关蛋白1的表达与临床病理特征及预后的关系研究[J].,2020,(22):4239-4243 |
| 食管癌组织人端粒酶反转录酶、肿瘤转移相关蛋白1的表达与临床病理特征及预后的关系研究 |
| Expression of Human Telomerase Reverse Transcriptase and Tumor Metastasis Associated Protein 1 in Esophageal Cancer and Its Relationship with Clinicopathological Features and Prognosis |
| 投稿时间：2020-02-28 修订日期：2020-03-24 |
| DOI：10.13241/j.cnki.pmb.2020.22.008 |
| 中文关键词: 食管癌 人端粒酶反转录酶 肿瘤转移相关蛋白1 临床病理特征 预后 |
| 英文关键词: Esophageal cancer Human telomerase reverse transcriptase Tumor metastasis associated protein 1 Clinicopathological features Prognosis |
| 基金项目:广东省医学科研基金项目（B20161240） |
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| 中文摘要: |
| 摘要 目的： 探讨食管癌组织中人端粒酶反转录酶（hTERT）、肿瘤转移相关蛋白1（MTA1）的表达与临床病理特征及预后的关系。方法：选择2015年1月至2016年10月我院收治的食管癌患者80例，应用免疫组织化学染色法检测其癌组织和癌旁组织中hTERT、MTA1表达，分析食管癌组织中hTERT、MTA1表达与临床病理特征的关系及其表达的相关性。所有患者均随访36个月，观察不同hTERT、MTA1表达情况患者的生存情况并分析hTERT、MTA1的表达与患者预后的关系。结果：食管癌组织中hTERT、MTA1阳性率显著高于癌旁组织（P<0.05）。中低分化、TNM分期为III+IV期、有淋巴结转移者食管癌组织hTERT、MTA1阳性率分别高于高分化、TNM分期为I+II期、无淋巴结转移者（P<0.05），不同性别、年龄、病灶最大直径者、肿瘤部位、病理类型食管癌组织hTERT、MTA1阳性率比较均无统计学差异（P>0.05）。Spearman相关分析显示，食管癌组织中hTERT表达与MTA1表达呈正相关（r=0.645，P=0.000）。随访36个月后，患者存活33例，存活率41.25%（33/80），食管癌组织hTERT阴性、MTA1阴性患者生存率、中位生存期分别为64.29%（9/14）、23.6个月，60.87%（14/23）、24.9个月均显著优于hTERT阳性、MTA1阳性患者的36.36%（24/66）、19.2个月，33.33%（19/57）、18.5个月（P<0.05）。结论：食管癌组织中存在hTERT、MTA1异常高表达，其水平与食管癌的组织分化程度、TNM分期、淋巴结转移相关，且其表达情况与食管癌患者预后有密切关系。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between the expression of human telomerase reverse transcriptase(hTERT)and metastasis tumor associated protein 1(MTA1) and the clinicopathological characteristics and prognosis of esophageal cancer. Methods: Selected 80 patients with esophageal cancer from January 2015 to October 2016. The levels of hTERT and MTA1 in cancer tissues and adjacent tissues were detected by immunohistochemistry, and the relationship between hTERT and MTA1 and clinicopathological features and their expression were analyzed. All patients were followed up for 36 months to observe the survival of patients with different expression of hTERT and MTA1, the relationship between the expression of hTERT and MTA1 and the prognosis was analyzed. Results: The positive rates of hTERT and MTA1 in esophageal carcinoma were significantly higher than those in adjacent tissues (P<0.05). The positive rates of hTERT and MTA1 in esophageal cancer with low differentiation, TNM stage III + IV, lymph node metastasis were higher than those in high differentiation, TNM stage I + II, no lymph node metastasis(P<0.05). There was no significant difference in the positive rates of hTERT and MTA1 in esophageal cancer with different gender, age, the largest diameter of focus, tumor location, pathological type(P>0.05). Spearman correlation analysis showed that the expression of hTERT was positively correlated with the expression of MTA1 (r=0.645, P=0.000). After 36 months of follow-up, the survival rate of 33 patients was 41.25% (33/80). The survival rate and median survival time of esophageal cancer patients with hTERT negative and MTA1 negative were 64.29%(9/14), 23.6 months, 60.87% (14/23) and 24.9 months, respectively, which were significantly better than those of patients with hTERT positive and MTA1 positive in 36.36% (24/66), 19.2 months, 33.33% (19/57) and 18.5 months (P<0.05). Conclusion: There are abnormal high expression of hTERT and MTA1 in esophageal cancer. The expression of hTERT and MTA1 is closely related to tissue differentiation, TNM stage and lymph node metastasis of esophageal cancer, and its expression is closely related to the survival period of esophageal cancer patients. |
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