| 郑 方,李文魁,刘 波,尤晰樱,佟 丹.佐金平木联合健脾化痰法对多发性抽动症患儿肌肉功能、肾脏损害及血清GABA、NE的影响[J].,2020,(21):4143-4146 |
| 佐金平木联合健脾化痰法对多发性抽动症患儿肌肉功能、肾脏损害及血清GABA、NE的影响 |
| Effects of Zuojin Pingmu Combined with Jianpi Huatan Therapy on Muscle Function, Kidney Damage and Serum GABA and NE in Children with Tourette Syndrome |
| 投稿时间：2020-01-31 修订日期：2020-02-26 |
| DOI：10.13241/j.cnki.pmb.2020.21.032 |
| 中文关键词: 佐金平木 健脾化痰法 多发性抽动症 肌肉功能 肾脏 ?酌-氨基丁酸 去甲肾上腺素 |
| 英文关键词: Zuojin Pingmu Jianpi Huatan therapy Tourette syndrome Muscle function Kidney Gamma-aminobutyric acid Norepinephrine |
| 基金项目:陕西省社会发展科技攻关项目（2016SF-213） |
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| 中文摘要: |
| 摘要 目的：探讨佐金平木联合健脾化痰法对多发性抽动症（TS）患儿肌肉功能、肾脏损害及血清γ-氨基丁酸（GABA）、去甲肾上腺素（NE）的影响。方法：选取2017年2月~2019年2月期间我院收治的TS患儿83例，根据随机数字表法将患儿分为对照组（n=41）和研究组（n=42），对照组患儿给予氟哌啶醇治疗，研究组在对照组的基础上给予佐金平木联合健脾化痰法治疗，比较两组患儿临床疗效、肌肉功能、肾脏损害及GABA、NE水平，记录两组治疗期间不良反应情况。结果：研究组治疗3个月后的总有效率为90.48%，高于对照组的73.17%（P<0.05）。两组治疗3个月后耶鲁综合抽动严重程度量表（YGTSS）评分均下降，且研究组低于对照组（P<0.05）。两组患儿治疗3个月后血清尿素氮（BUN）、血肌酐（Scr）水平均降低，但研究组高于对照组（P<0.05）。两组患儿治疗3个月后血清GABA、NE水平均升高，且研究组高于对照组（P<0.05）。研究组、对照组不良反应发生率分别为16.67%（7/42）、24.39%（10/41），差异无统计学意义（P>0.05）。结论：佐金平木联合健脾化痰法治疗TS患儿，可有效改善患儿肌肉功能及血清GABA、NE水平，同时可减轻肾脏损害，用药安全性较好，临床应用价值较高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of Zuojin Pingmu combined with Jianpi Huatan therapy on muscle function, kidney damage and serum gamma-aminobutyric acid (GABA) and norepinephrine (NE) in children with tourette syndrome (TS). Methods: 83 children with TS who were admitted to our hospital from February 2017 to February 2019 were selected, and they were divided into control group (n=41) and study group (n=42) according to random number table method. The control group was treated with haloperidol. The study group was treated with Zuojin Pingmu combined with Jianpi Huatan therapy on the basis of the control group. Clinical efficacy, muscle function, kidney damage and serum levels of GABA and NE were were compared between the two groups. Adverse reactions during treatment were recorded between the two groups. Results: The clinical efficacy of the study group was 90.48% at 3 months after treatment, which was higher than that of the control group 73.17% (P<0.05). 3 months after treatment, the Yale Comprehensive Tourette Severity Scale (YGTSS) scores of two groups decreased, and that of the study group was lower than that of the control group (P<0.05). 3 months after treatment, the levels of serum urea nitrogen (BUN) and creatinine (Scr) of two groups decreased, but those of the study group were higher than those of the control group (P<0.05). The levels of serum GABA and NE of the two groups increased at 3 months after treatment, and those of the study group were higher than those of the control group (P<0.05). The incidence of adverse reactions in the study group and the control group were 16.67% (7/42) and 24.39% (10/41), respectively, there was no significant difference （P>0.05）. Conclusion: Zuojin Pingmu combined with Jianpi Huatan therapy can effectively improve the muscle function and levels of serum GABA, NE in children with TS, at the same time it can reduce kidney damage, drug safety is better, clinical application value is higher. |
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