| 陈俊杰,仝瀚文,陆俊杰,单 祎,葛志军.脓毒症患者血清TNF-α与T淋巴细胞亚群、凝血功能及预后的关系研究[J].,2020,(21):4126-4129 |
| 脓毒症患者血清TNF-α与T淋巴细胞亚群、凝血功能及预后的关系研究 |
| The Relationship between Serum TNF-α and T Lymphocyte Subsets, Coagulation Function and Prognosis in Sepsis Patients |
| 投稿时间：2020-03-15 修订日期：2020-04-11 |
| DOI：10.13241/j.cnki.pmb.2020.21.028 |
| 中文关键词: 脓毒症 肿瘤坏死因子-α T淋巴细胞亚群 凝血功能 预后 关系 |
| 英文关键词: Sepsis Tumor necrosis factor-α T lymphocyte subsets Coagulation function Prognosis Relationship |
| 基金项目:江苏省科技厅科技支撑计划项目（BE20140861）；宜兴市科技局社会发展项目（2018SF25） |
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| 中文摘要: |
| 摘要 目的：探讨脓毒症患者血清肿瘤坏死因子-α（TNF-α）与T淋巴细胞亚群、凝血功能及预后的关系。方法：选取2017年4月~2019年4月期间我院收治的脓毒症患者93例作为脓毒症组，另选取同期来我院行健康体检的志愿者90例作为对照组，比较脓毒症组、对照组的TNF-α、T淋巴细胞亚群、凝血功能，根据28d后转归情况分为死亡组和存活组，比较死亡组和存活组TNF-α、T淋巴细胞亚群水平、凝血功能，采用Pearson相关分析分析TNF-α与T淋巴细胞亚群、凝血功能的相关性。结果：脓毒症组TNF-α高于对照组，凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）长于对照组，而CD3+、CD4+、CD4+/CD8+均低于对照组（P<0.05）；脓毒症组、对照组CD8+比较差异无统计学意义（P>0.05）。死亡组TNF-α高于存活组，PT、APTT长于存活组，而CD3+、CD4+、CD4+/CD8+均低于存活组（P<0.05）；死亡组、存活组CD8+比较差异无统计学意义（P>0.05）。Pearson相关分析结果显示，脓毒症患者血清TNF-α与PT、APTT呈正相关，与CD3+、CD4+、CD4+/CD8+呈负相关（P<0.05）；TNF-α与CD8+无明显相关性（P>0.05）。结论：脓毒症患者血清TNF-α、T淋巴细胞亚群、凝血功能均存在异常变化，TNF-α与患者的T淋巴细胞亚群、凝血功能和预后有关，检测TNF-α有助于评估脓毒症患者的病情和预后。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum tumor necrosis factor-α (TNF-α) and T lymphocyte subsets, coagulation function and prognosis in sepsis patients. Methods: 93 patients with sepsis who were admitted to our hospital from April 2017 to April 2019 were selected as sepsis group, and 90 volunteers who received health examination in our hospital during the same period were selected as control group. TNF-α, T lymphocyte subsets and coagulation function of sepsis group and control group were compared, and T lymphocyte subsets and coagulation function of death group and survival group in sepsis patients were compared. According to the outcome after 28 days, the patients were divided into death group and survival group. The levels of TNF-α and T lymphocyte subsets and coagulation function were compared between death group and survival group. The correlation of TNF-α with T lymphocyte subsets and coagulation function were analyzed by Pearson correlation analysis. Results: TNF-α in sepsis group was higher than that in the control group. The prothrombin time (PT) and activated partial thromboplastin time (APTT) were longer than those in the control group, while CD3+, CD4+, CD4+/CD8+ in the sepsis group were lower than those in the control group (P<0.05). There was no significant difference in CD8+ between the sepsis group and the control group (P>0.05). TNF-α in the death group was higher than that in the survival group, PT and APTT in the death group were longer than those in the survival group, while CD3+, CD4+, CD4+/CD8+ were lower than those in the survival group (P<0.05). There was no significant difference in CD8+ between the death group and the survival group (P>0.05). Pearson correlation analysis showed that TNF-α were positively correlated with PT and APTT, negatively correlated with CD3+, CD4+, CD4+/CD8+ (P<0.05), there was no significant correlation between TNF-α and CD8+ (P>0.05). Conclusion: There are abnormal changes in TNF-α, T lymphocyte subsets and coagulation function in sepsis patients, TNF-α is associated with T lymphocyte subsets, coagulation function, and prognosis of patients, the detection of TNF-α is helpful to evaluate the condition and prognosis of sepsis patients. |
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