| 李 桃,苗 蓓,周 冰,李开鹏,邱坤武.复方谷氨酰胺联合双歧杆菌三联活菌胶囊治疗腹泻型肠易激综合征患者的临床疗效[J].,2020,(21):4097-4100 |
| 复方谷氨酰胺联合双歧杆菌三联活菌胶囊治疗腹泻型肠易激综合征患者的临床疗效 |
| Clinical Effect of Compound Glutamine Combined with Bifidobacterium Sanlian Capsule on the Diarrhea Type Irritable Bowel Syndrome |
| 投稿时间：2020-05-06 修订日期：2020-06-30 |
| DOI：10.13241/j.cnki.pmb.2020.21.021 |
| 中文关键词: 双歧杆菌三联活菌胶囊 复方谷氨酰胺 腹泻型肠易激综合征 |
| 英文关键词: Bifidobacterium Triple Viable Bacteria Capsule Compound Glutamine Diarrhea Irritable Bowel Syndrome |
| 基金项目:江苏省高校自然科学研究项目(15KJB320001) |
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| 中文摘要: |
| 摘要 目的：研究复方谷氨酰胺以及双歧杆菌三联活菌胶囊联用治疗腹泻型肠易激综合征患者的临床疗效。方法：选择2016年1月～2020年2月安徽省濉溪县医院收治的81例腹泻型肠易激综合征患者，将其随机分为两组。对照组41例患者仅口服420 mg的双歧杆菌三联活菌胶囊，每天3次；观察组40例患者加用500 mg的复方谷氨酰胺，每天3次。检测两组治疗前后的血清内毒素、二胺氧化酶活性及D-乳酸水平；血清白介素-6(Interleukin -6，IL-6)、肿瘤坏死因子-α(Tumor necrosis factor alpha，TNF-α)、白介素-8(Interleukin -8，IL-8)、高敏C反应蛋白(High sensitive C reactive protein，hs-CRP)水平；血浆生长抑素和血管活性肠肽水平并比较治疗后临床疗效及治疗过程中不良反应的发生情况。结果：治疗后，观察组的有效率为97.5%，明显高于对照组(75.61%，P<0.05)；两组的血清内毒素、二胺氧化酶活性及D-乳酸、IL-6、TNF-α、IL-8、hs-CRP水平、血浆生长抑素和血管活性肠肽水平均较治疗前明显降低(P<0.05)，且观察组以上指标均明显低于对照组(P<0.05)。观察组治疗期间的有2例嗜睡、头晕、乏力不适，发生率为5.00 %，对照组有2例头晕，1例头痛、口干，发生率为7.32 %，两组对比无统计学意义（P>0.05）。结论：复方谷氨酰胺联合双歧杆菌三联活菌胶囊治疗腹泻型肠易激综合征患者的临床效果明显优于单用双歧杆菌三联活菌胶囊治疗，其可有效修复肠黏膜屏障损伤，可能与其减轻炎症反应并改善胃肠激素水平有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical effecacy of compound glutamine combined with bifidobacterium sanlian capsule on diarrhea type irritable bowel syndrome. Methods: Eighty-one patients with diarrhea type irritable bowel syndrome were selected from Suixi County Hospital of Anhui Province from January 2016 to February 2020 were randomly divided into two groups randomly. The control group (n=41) only took 420 mg bifidus triple viable capsule three times a day, the observation group (n=40) added 500 mg compound glutamine three times a day. The levels of serum endotoxin, diamine oxidase activity and D-lactate, serum IL-6, TNF-α, IL-8, hs-CRP levels, plasma somatostatin and vasoactive intestinal peptide were measured before and after treatment, and also detected compare clinical efficacy after treatment and occurrence of adverse reactions during treatment. Results: After treatment, the effective rate of the observation group was 97.5 %, which was significantly higher than that of the control group (75.61 %, P<0.05). The serum endotoxin, diamine oxidase activity, D-lactic acid, IL-6, TNF-α, IL-8, hs-CRP levels, plasma somatostatin and vasoactive intestinal peptide levels of the two groups were significantly reduced (P<0.05), and the above indexes in the observation group were significantly lower than those in the control group (P<0.05). The observation group had 2 cases of drowsiness, dizziness, fatigue and discomfort during the treatment period, the incidence rate was 5.00 %, the control group had 2 cases of dizziness, 1 case of headache and dry mouth, the incidence rate was 7.32 %, there was no statistical significance between the two groups (P>0.05). Conclusion: The clinical effect of compound glutamine combined with Bifidobacterium triple live bacteria capsule in the treatment of patients with diarrhea irritable bowel syndrome is significantly better than that of bifidobacterium triple live bacteria capsule alone. Inflammation is related to improving gastrointestinal hormone levels. |
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