| 行海舰,李 健,肖红玉,雷 茜,孙 敏.150例川崎病患儿的冠脉受损的高危因素分析[J].,2020,(21):4068-4071 |
| 150例川崎病患儿的冠脉受损的高危因素分析 |
| Analysis of High Risk Factors for Coronary Artery Damage in 150 Children with Kawereaki Disease |
| 投稿时间：2020-02-27 修订日期：2020-03-22 |
| DOI：10.13241/j.cnki.pmb.2020.21.014 |
| 中文关键词: 川崎病 冠脉受损 高危因素 白介素-1β 肿瘤坏死因子-α |
| 英文关键词: Kawereaki disease Coronary artery damage High-risk factors Interleukin-1β Tumor necrosis factor-α |
| 基金项目:国家自然科学基金项目（81470452） |
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| 中文摘要: |
| 摘要 目的：分析与调查川崎病患儿的冠脉受损的高危因素，为改善患儿预后提供参考。方法：采用病例对照的方法，研究时间为2016年8月至2019年4月，选择150例在本院诊治的川崎病患儿，调查所有患者的流行病学状况并进行血液学检测。随访患儿的冠脉受损发生情况并进行高危因素调查与分析。结果：随访6个月，150例川崎病患儿中继发冠脉受损44例，发生率为29.3 %，作为病例组，106例冠脉未受损的为对照组。两组一般资料对比无统计学意义(P>0.05)。两组入院时的白细胞计数、血小板计数、红细胞比容与血红蛋白值对比差异无统计学意义(P>0.05)。病例组入院时的血清白介素-1β(Interleukin-1β，IL-1β)、白介素-6(Interleukin-6，IL-6)、肿瘤坏死因子-α(Tumor necrosis factor-α，TNF-α)值都显著高于对照组(P<0.05)。Logistic回归方程分析显示IL-1β、IL-6、TNF-α都为导致冠脉受损发生的影响因素(P<0.05)。结论：川崎病继发冠脉受损比较常见，临床症状多表现为皮疹、球结膜充血、颈部淋巴结肿大、手足肿胀，IL-1β、IL-6、TNF-α为导致冠脉受损发生的影响因素。 |
| 英文摘要: |
| ABSTRACT Objective: To analysis and investigate the high-risk factors of coronary artery damage in children with Kawereaki disease, and to provide a reference for improving the prognosis of children. Methods: Used a case-control method, the study period were from August 2016 to April 2019. 150 cases of children with Kawereaki disease treated in our hospital were selected as the research objects. The epidemiological status of all cases were investigated and hematological tests were performed. Patients with coronary artery damage were followed up and the risk factors were investigated and analyzed. Results: During 6 months followed-up, there were 44 cases of coronary artery damage occurred in 150 cases of children with Kawereaki disease, the incidence rates were 29.3%. There were no significant differences in gender, age, and clinical symptoms between the two groups of children at admission (P>0.05). There were no significant differences in white blood cell counts, platelet counts, hematocrits, and hemoglobin values compared between the two groups of children at admission (P>0.05). The serum Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Tumor necrosis factor-α (TNF-α) in the case group were significantly higher than those in the control group (P<0.05). Logistic regression equation analysis showed that IL-1β, IL-6 and TNF-α were all influencing factors leading to the occurrence of coronary artery damage(P<0.05). Conclusion: Kawereaki disease is more common with secondary coronary artery damage. Clinical symptoms are mostly rash, conjunctival hyperemia, cervical lymphadenopathy, and swelling of the hands and feet. IL-1β, IL-6, and TNF-α are the causes of coronary artery damage. Influencing factors. |
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