| 李 程,王永胜,王 波,罗家宇,郭新权.RPLU术对重度肾积水的上尿路结石患者尿ET-1、AQP-1、MCP-1水平的影响[J].,2020,(20):3978-3982 |
| RPLU术对重度肾积水的上尿路结石患者尿ET-1、AQP-1、MCP-1水平的影响 |
| Effect of RPLU on Urinary ET-1, AQP-1 and MCP-1 Levels in Patients with Upper Urinary Calculi with Severe Hydronephrosis |
| 投稿时间：2020-05-05 修订日期：2020-05-29 |
| DOI：10.13241/j.cnki.pmb.2020.20.039 |
| 中文关键词: 重度肾积水 上尿路结石 后腹腔镜下输尿管切开取石术 内皮素-1 水通道蛋白-1 单核细胞趋化蛋白-1 |
| 英文关键词: Severe hydronephrosis Upper urinary calculi Retroperitoneoscopic ureterolithotomy: Endothelin-1 Aquaporin-1 Monocyte chemotactic protein -1 |
| 基金项目:四川省科研基金资助项目（2018HU368） |
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| 中文摘要: |
| 摘要 目的：探讨后腹腔镜下输尿管切开取石术（RPLU）对重度肾积水的上尿路结石患者尿内皮素-1（ET-1）、水通道蛋白-1（AQP-1）、单核细胞趋化蛋白-1（MCP-1）水平的影响。方法：收集2018年4月~2019年11月我院收治的106例重度肾积水的上尿路结石患者为研究对象，按照随机数字表法分为对照组和研究组，每组53例，对照组采用输尿管镜取石术治疗，研究组采用RPLU术治疗，对比两组手术情况，手术前后血红蛋白、肾功能、尿ET-1、AQP-1、MCP-1水平，手术并发症发生情况。结果：研究组手术时间及住院时间多于对照组，结石清除率高于对照组，比较差异有统计学意义（P<0.05）；两组术中出血量、术后排气时间比较差异无统计学意义（P>0.05）。术后，两组血红蛋白较术前无显著差异（P>0.05）。术后，两组血肌酐及血尿酸氮均下降，两组比较差异无统计学意义（P>0.05）。术后，两组尿ET-1、AQP-1、MCP-1水平均下降，两组比较无统计学意义（P>0.05）。两组并发症总发生率比较无统计学意义（P>0.05）。结论：RPLU术是治疗重度肾积水的上尿路结石清除率高，创伤小，可作为重度肾积水伴上尿路结石安全、有效的术式。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of retroperitoneal laparoscopic ureterolithotomy (RPLU) on urinary endothelin -1(ET-1), aquaporin -1(AQP-1) and monocyte chemoattractant protein -1(MCP-1) levels in patients with upper urinary calculi with severe hydronephrosis. Methods: 106 patients with upper urinary tract calculi with severe hydronephrosis admitted to our hospital from April 2018 to November 2019 were collected as research objects and divided into control group and research group according to random number table method, 53 cases in each group. The control group was treated with ureteroscopic lithotomy, and the research group was treated with RPLU. The operation conditions, including hemoglobin, renal function, urine ET-1, AQP-1, MCP-1 levels before and after the operation, and the occurrence of surgical complications of the two groups were compared. Results: The operation time and hospitalization time of the study group were longer than those of the control group, and the stone clearance rate was higher than that of the control group, the difference was statistically significant (P<0.05). There was no significant difference in intraoperative blood loss and postoperative exhaust time between the two groups (P>0.05). After operation, there was no significant difference in hemoglobin between the two groups (P>0.05). After operation, serum creatinine and uric acid and nitrogen in both groups decreased, and there was no significant difference between the two groups (P>0.05). After the operation, the urine ET-1, AQP-1 and MCP-1 levels in both groups decreased, the difference was not statistically significant (P>0.05). There was no statistical difference in the total incidence of complications between the two groups (P>0.05). Conclusion: RPLU is a safe and effective method for the treatment of severe hydronephrosis with upper urinary tract stones due to its high clearance rate and small trauma. |
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