| 孙嘉伟,刘 欣,马媛媛,卢 秀,朱孟琳.龙血竭胶囊合九华膏对环状混合痔术后患者创面愈合、血清炎性因子和免疫功能的影响[J].,2020,(19):3695-3698 |
| 龙血竭胶囊合九华膏对环状混合痔术后患者创面愈合、血清炎性因子和免疫功能的影响 |
| Effects of Longxuejie Capsule Combined with Jiuhua Ointment on Wound Healing, Serum Inflammatory Factors and Immune Function after Operation of Patients with Circular Mixed Hemorrhoids |
| 投稿时间：2020-04-07 修订日期：2020-04-30 |
| DOI：10.13241/j.cnki.pmb.2020.19.019 |
| 中文关键词: 龙血竭胶囊 九华膏 环状混合痔 创面愈合 炎性因子 免疫功能 |
| 英文关键词: Longxuejie capsule Jiuhua ointment Circular mixed hemorrhoids Wound healing Inflammatory factors Immune function |
| 基金项目:山东省自然科学基金项目（ZR2015HL110） |
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| 中文摘要: |
| 摘要 目的：探讨龙血竭胶囊合九华膏对环状混合痔（RMH）术后患者创面愈合、血清炎性因子和免疫功能的影响。方法：选取2016年7月~2019年12月期间我院收治的RMH患者93例，根据随机数字表法分为对照组（n=46，马应龙麝香痔疮膏治疗）和研究组（n=47，龙血竭胶囊合九华膏治疗），比较两组患者疗效、创面愈合情况、不良反应、血清炎性因子和免疫功能。结果：治疗10 d后，研究组的临床总有效率为89.36%（42/47），高于对照组的71.74%（33/46）（P<0.05）。两组治疗10 d后创面渗液、水肿、疼痛、创面肉芽组织评分下降，创面面积减小，且研究组低于对照组（P<0.05）。两组治疗10 d后肿瘤坏死因子-α（TNF-α）、白介素-6（IL-6）、白介素-2（IL-2）均下降，且研究组低于对照组（P<0.05）。两组治疗10 d后免疫球蛋白G（IgG）、免疫球蛋白A（IgA）、免疫球蛋白M（IgM）均升高，且研究组高于对照组（P<0.05）。研究组并发症发生率低于对照组（P<0.05）。结论：RMH患者术后采用龙血竭胶囊合九华膏治疗，疗效较好，可有效促进创面愈合，减轻炎症反应，改善机体免疫功能，同时还可减少并发症发生率。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of Longxuejie capsule combined with Jiuhua ointment on wound healing, serum inflammatory factors and immune function after operation of patients with circular mixed hemorrhoids (RMH). Methods: 93 patients with RMH admitted to our hospital from July 2016 to December 2019 were selected, they were divided into control group (n=46, Ma Yinglong musk Hemorrhoid Ointment treatment) and study group (n=47, Longxuejie capsule combined with Jiuhua ointment treatment). The curative effect, wound healing, adverse reactions serum inflammatory factors and immune function of the two groups were compared. Results: 10 d after treatment, the total clinical effective rate of the study group was 89.36% (42/47), which was higher than 71.74% (33/46) of the control group(P<0.05). The wound exudation, edema, pain, wound granulation tissue score and wound area of the two groups at 10 d after treatment decreased, and those of study group were lower than those of control group(P<0.05). Tumor necrosis factor - α (TNF-α), interleukin-6(IL-6) and interleukin-2(IL-2) were all decreased of the two groups at 10d after treatment, and those of study group were lower than those of control group (P<0.05). Immunoglobulin G(IgG), immunoglobulin A(IGA) and immunoglobulin M(IgM) increased in both groups at 10d after treatment, and those of study group were higher than those of control group (P<0.05). The incidence of complications in the study group was lower than that in the control group (P<0.05). Conclusion: Patients with RMH are used Longxuejie capsule combined with Jiuhua ointment treatment is effective, which can effectively promote wound healing, reduce inflammatory reaction, improve immune function, at the same time, it can reduce the incidence of complications. |
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