| 马 妮,崔小丽,王 妮,高俊卿,张 强.银丹心脑通软胶囊联合长春西汀治疗缺血性脑卒中患者的疗效[J].,2020,(18):3482-3485 |
| 银丹心脑通软胶囊联合长春西汀治疗缺血性脑卒中患者的疗效 |
| Effect of Yindanxinnaotong Soft Capsule Combined with Vinpocetine on Patients with Ischemic Stroke |
| 投稿时间：2019-12-08 修订日期：2019-12-31 |
| DOI：10.13241/j.cnki.pmb.2020.18.018 |
| 中文关键词: 银丹心脑通软胶囊 长春西汀 缺血性脑卒中 白细胞介素1β 单核细胞趋化蛋白-1 血管内皮生长因子 |
| 英文关键词: Yindanxinnaotongsoft Capsule Vinpocetine Ischemic Stroke Interleukin-1 β Monocyte Chemoattractant Protein-1 Vascular Endothelial Growth Factor |
| 基金项目:陕西省科技厅基金项目（2017SF-264） |
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| 中文摘要: |
| 摘要 目的：研究银丹心脑通软胶囊联合长春西汀治疗缺血性脑卒中患者的疗效。方法：选择2016年1月～2018年12月我院的83例缺血性脑卒中患者，随机分为两组。对照组静脉滴注30 mg的长春西汀，每天1次。观察组在长春西汀的基础上，口服4 粒银丹心脑通软胶囊，每天3 次。比较两组的改良爱丁堡一斯堪的那维亚神经功能缺损量表（Modified Edinburgh Scandinavian neurological deficit scale，MESS）、Barthel 指数、血清白细胞介素1β（Interleukin 1 β，IL-1β）、单核细胞趋化蛋白-1（Monocyte chemoattractant protein-1，MCP-1）、血管内皮生长因子（Vascular endothelial growth factor，VEGF）水平。结果：观察组的有效率明显高于对照组（P<0.05）；治疗后，两组的MESS 评分明显降低（P<0.05），Barthel 指数明显升高（P<0.05），且观察组的MESS 评分和Barthel 指数明显优于对照组（P<0.05）；治疗后，两组的血清IL-1β、MCP-1水平明显降低（P<0.05），血清VEGF水平明显升高（P<0.05），且观察组上述指标优于对照组（P<0.05）。结论：银丹心脑通软胶囊联合长春西汀能降低缺血性脑卒中患者炎症细胞因子的过度表达，改善脑血流灌注和神经功能，有效控制缺血性脑卒中的进展。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of Yindanxinnaotong soft capsule combined with vinpocetine on patients with ischemic stroke. Methods: Selected 83 cases of patients with ischemic stroke who were treated in our hospital from January 2016 to December 2018, divided into two groups randomly. In the control group, 30 mg vinpocetine was given intravenously once a day. On the basis of vinpocetine, the observation group took four Yindanxinnaotong soft capsules three times a day. The modified Edinburgh Scandinavian neurological deficit scale（MESS）, Barthel index, interleukin-1 β（IL-1 β）, monocyte chemoattractant protein-1（MCP-1）, vascular endothelial growth factor, VEGF） were compared between the two groups. Results: The effective rate of the observation group was significantly higher than control group（P<0.05）. After treatment, the scores of mess and Barthel Index in the two groups were significantly lower（P<0.05）, and the scores of mess and Barthel Index in the observation group were significantly higher than those in the control group （P<0.05）. After treatment, the serum levels of IL-1 β and MCP-1 in the two groups were significantly lower （P<0.05）, the serum VEGF level was significantly higher（P<0.05）, and the serum levels of IL-1 β and MCP-1 in the observation group were significantly lower than those in the control group（P<0.05）, and the serum VEGF level was significantly higher than that in the control group（P<0.05）. Conclusion: Yindanxinnaotong soft capsule combined with vinpocetine can reduce the over expression of inflammatory cytokines, improve cerebral blood flow perfusion and nerve function, and effectively control the progress of ischemic stroke. |
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