| 郑艳贺,孙丕云,任艳丁,李 响,于金玲.老年急性脑梗死患者外周血EMMPRIN表达与颈动脉易损斑块的相关性[J].,2020,(15):2996-3000 |
| 老年急性脑梗死患者外周血EMMPRIN表达与颈动脉易损斑块的相关性 |
| Correlation between Expression of EMMPRIN and Carotid Artery Vulnerable Plaque in Elderly Patients with Acute Cerebral Infarction |
| 投稿时间：2020-01-24 修订日期：2020-02-18 |
| DOI：10.13241/j.cnki.pmb.2020.15.041 |
| 中文关键词: 老年急性脑梗死 EMMPRIN 颈动脉易损斑块 |
| 英文关键词: Acute cerebral infarction in the elderly EMMPRIN Vulnerable carotid plaque |
| 基金项目:黑龙江省博士后基金资助项目（LBH－Z17152） |
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| 中文摘要: |
| 摘要 目的：分析老年急性脑梗死(acute cerebral infarction，ACI)患者外周血血小板表面细胞外基质金属蛋白酶诱导因子(EMMPRIN)表达与颈动脉易损斑块的相关性。方法：收集2017年3月至2019年3月于我院收治的老年ACI患者作为研究对象，按照超声下颈动脉斑块的分类标准，将颈动脉斑块呈高回声受检者纳入稳定斑块组(n=41)，斑块呈低回声或等回声的受检者则纳入易损斑块组(n=52)。应用logisitc回归模型，分析ACI患者颈动脉易损斑块的影响因素；采用Pearson相关分析，研究外周血单个核细胞EMMPRIN与各临床指标的相关性；采用受试者工作特征(ROC)曲线评价EMMPRIN诊断颈动脉易损斑块的准确性。结果：易损斑块组高脂血症、高血压病、2型糖尿病比例以及FPG、IL-6、IL-1β、MMP-9、MCP-1、TNF-α、LDL、EMMPRIN水平均高于稳定斑块组，组间差异显著(P<0.05)；易损斑块组HDL水平均低于稳定斑块组，组间差异显著(P<0.05)。person相关分析结果显示，EMMPRIN与IL-6、IL-1β、MMP-9、TNF-?琢均呈正相关(r=0.348，0.374，0.418，0.427，P<0.05)。logistic多因素回归分析显示，结果显示，高血压病、2型糖尿病、IL-1β、MMP-9、EMMPRIN均为颈动脉易损斑块的危险因素。EMMPRIN的AUC优于MMP-9、IL-1β(P =0.016，0.039，均P<0.05)。结论：外周血血小板表面EMMPRIN水平可能与老年ACI患者颈动脉斑块稳定性有关，可作为辅助临床诊断颈动脉易损斑块的预警指标，对于ACI的发生、发展均具有重要的临床意义。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the correlation between the expression of extracellular matrix metalloproteinase-inducing factor (EMMPRIN) on the peripheral blood platelet surface of elderly patients with acute cerebral infarction (ACI) and carotid artery vulnerable plaque. Methods: Elderly ACI patients admitted to our department from March 2017 to March 2019 were collected as research subjects. Carotid plaques with high echogenicity were included in the stable subjects according to the classification criteria of carotid plaques under ultrasound. Plaque group (n = 41), subjects with hypoechoic or isoechoic plaques were included in the vulnerable plaque group (n = 52). Logisitc regression model was used to analyze the influencing factors of carotid vulnerable plaques in ACI patients; Pearson correlation analysis was used to study the correlation between peripheral blood mononuclear cells EMMPRIN and clinical indicators; receiver operating characteristic (ROC) curve was used to evaluate EMMPRIN Accuracy of diagnosis of vulnerable carotid plaques. Results: The proportions of hyperlipidemia, hypertension, and type 2 diabetes, as well as FPG, IL-6, IL-1β, MMP-9, MCP-1, TNF-α, LDL, and EMMPRIN in the vulnerable plaque group were higher than those in the vulnerable plaque group. The stable plaque group had significant differences between the groups (P<0.05); the vulnerable plaque group had a lower HDL level than the stable plaque group, with significant differences between the groups (P<0.05). The results of person correlation analysis showed that EMMPRIN was positively correlated with IL-6, IL-1β, MMP-9, and TNF-α (r= 0.348, 0.374, 0.418, 0.427, P<0.05). Logistic multivariate regression analysis showed that the results showed that hypertension, type 2 diabetes, IL-1β, MMP-9, EMMPRIN are risk factors of carotid vulnerable plaque. The AUC of EMMPRIN was better than that of MMP-9 and IL-1β (P = 0.016, 0.039, all P<0.05). Conclusion: The level of EMMPRIN on the surface of peripheral blood platelets may be related to the stability of carotid plaque in elderly patients with ACI. It can be used as an early warning indicator to assist in the clinical diagnosis of vulnerable plaque in the carotid artery. |
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