| 方 芳,汪 宏,耿克明,张赟辉,罗 军.血清Cys C、RBP和尿mALB检测对肾小球滤过功能及肾功能损伤诊断分析[J].,2020,(15):2983-2986 |
| 血清Cys C、RBP和尿mALB检测对肾小球滤过功能及肾功能损伤诊断分析 |
| Diagnostic Values of Serum Cys C, Retinol Binding Protein and Urine mALB on Glomerulonephritis Filtration Function and Renal Function Damage |
| 投稿时间：2020-02-27 修订日期：2020-03-22 |
| DOI：10.13241/j.cnki.pmb.2020.15.038 |
| 中文关键词: Cys C 视黄醇结合蛋白 尿mALB 肾小球肾炎 滤过功能 肾功能损伤 |
| 英文关键词: Cys C Retinol binding protein Urine mALB Glomerulonephritis Filtration function Renal function damage |
| 基金项目:安徽省自然科学基金项目（1408085）；黄山市科技计划项目（2017KN-04） |
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| 中文摘要: |
| 摘要 目的：探讨血清胱抑素 C(Cys-C)、视黄醇结合蛋白(retinol binding protein，RBP)及尿尿微量白蛋白(mAlb)检测对肾小球肾炎的滤过功能及肾功能损伤的诊断价值。方法：以我院2017年12月至2018年12月收治的42例肾小球肾炎患者作为观察组、39例健康体检合格者为对照组，比较两组血清Cys-C、RBP及 mAlb水平，观察组不同预后者肾功能指标水平，观察组不同预后者血清Cys C 、RBP及尿mALB水平，两组血清Cys C 、RBP及尿mALB检出率。结果：观察组血清Cys C 、RBP及尿mALB水平均显著高于对照组[（2.73±0.72）mg/L vs（0.85±0.21）mg/L，（104.72±21.36）mg/L vs（37.69±8.91）mg/L，（39.51±4.02）mg/L vs（7.08±1.26）mg/L]（P＜0.05）；10例CRF/CKD 和病情缓解或无进展24h尿蛋白水平无显著差异（P＞0.05），血肌酐、尿素氮显著高于病情缓解或无进展组[（105.76±12.37）μmol/L vs（92.09±11.01）μmol/L，（17.02±2.73）μmol/L vs（7.15±1.06）μmol/L]（P＜0.05）；CRF者血清Cys C、RBP及尿mALB水平均显著高于病情缓解或无进展者[（3.91±0.56）mg/L vs（2.08±0.35）mg/L，（182.36±31.23）mg/L vs（47.08±9.35）mg/L，（258.68±70.27）mg/L vs（16.03±3.24）mg/L]（P＜0.05）；血清Cys C 、RBP及尿mALB阳性检出率分别为83.33％、76.19％、73.80％，联合检测率为92.85％，联合检出率显著高于单项指标检出率（P＜0.05）。结论：血清Cys C、视黄醇结合蛋白及尿mALB三者联合检测有效率较高，可用作评估肾小球肾炎患者的滤过功能及肾功能损伤，观察患者预后。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the clinical values of serum Cys C, retinol binding protein and urinary mAlb in diagnosis of glomerulonephritis. Methods: 42 patients with glomerulonephritis in our hospital from December 2017 to December 2018 were selected as the observation group, and 39 healthy subjects were selected as the control group. The levels of serum Cystatin C (Cys-C), retinol binding protein (RBP) and Microalbumin (mALB) in the two groups were observed. The level of renal function indexes in the observation group with different prognosis. The levels of serum Cys C, RBP and urinary malab in the two groups with different prognosis were observed. Results: The levels of serum Cys C, RBP and urinary mALB in the observation group were significantly higher than those in the control group[（2.73±0.72）mg/L vs（0.85±0.21）mg/L, （104.72±21.36）mg/L vs（37.69±8.91）mg/L, （39.51±4.02）mg/L vs（7.08±1.26）mg/L]（P＜0.05）. There was no significant difference in CRF/CKD, 24-hour urinary protein and urea nitrogen levels in 10 patients between remission and no progress（P＞0.05）. Serum creatinine and urea nitrogen water were significantly higher than those in remission or no progress group[（105.76±12.37）?滋mol/L vs（92.09±11.01）?滋mol/L, （17.02±2.73）?滋mol/L vs（7.15±1.06）?滋mol/L]（P＜0.05）. The levels of serum Cys C, RBP and urinary mALB in CRF patients were significantly higher than those in remission or no progression patients[（3.91±0.56）mg/L vs（2.08±0.35）mg/L,（182.36±31.23）mg/L vs（47.08±9.35）mg/L, （258.68±70.27）mg/L vs（16.03±3.24）mg/L]（P＜0.05）. The positive rates of serum Cys C, RBP and urinary mALB were 83.33%, 76.19% and 73.80%, respectively. The combined detection rate was 92.85%. The detection rate of combination was significantly higher than that of single index（P＜0.05）. Conclusion: The combined detection of serum Cys C, retinol binding protein and urinary mALB has a high effective rate, which can be used to evaluate the filtration function and renal function damage in patients with glomerulonephritis, and to observe the prognosis of patients. |
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