| 关炳星,张 倩,马立良,杨 勇,尹世策.脓毒症患者血清HMGB1、IGF-1水平变化及与T淋巴细胞亚群、预后的关系研究[J].,2020,(10):1984-1987 |
| 脓毒症患者血清HMGB1、IGF-1水平变化及与T淋巴细胞亚群、预后的关系研究 |
| Changes of Serum HMGB1 and IGF-1 Levels in Sepsis Patients and Their Relationship with T Lymphocyte Subsets and Prognosis |
| 投稿时间：2020-02-06 修订日期：2020-02-28 |
| DOI：10.13241/j.cnki.pmb.2020.10.041 |
| 中文关键词: 高迁移率族蛋白1 脓毒症 胰岛素样生长因子-1 T淋巴细胞亚群 预后 关系 |
| 英文关键词: High mobility group protein 1 Sepsis Insulin-like growth factor-1 T lymphocyte subsets Prognosis Relationship |
| 基金项目:河北省医学科学研究项目（20162720） |
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| 中文摘要: |
| 摘要 目的：探讨脓毒症患者血清高迁移率族蛋白1（HMGB1）、胰岛素样生长因子-1（IGF-1）水平变化及与T淋巴细胞亚群、预后的关系。方法：选取2016年2月~2018年12月期间我院收治的脓毒症患者139例，根据Sepsis 3.0定义，将脓毒症患者分成一般脓毒症组（n=73）及脓毒症休克组（n=66），根据患者进入重症监护室28d后的转归资料，将其分为存活组和死亡组。比较不同预后、不同病情严重程度的脓毒症患者血清IGF-1、HMGB1水平、急性病生理与慢性健康评价系统Ⅱ（APACHE II）评分以及T淋巴细胞亚群；采用Pearson相关分析血清HMGB1、IGF-1水平与T淋巴细胞亚群、APACHE II评分的关系。结果：一般脓毒症组CD3+、CD4+、CD4+/CD8+高于脓毒症休克组，CD8+低于脓毒症休克组（P<0.05）。脓毒症休克组血清HMGB1水平、APACHE II评分均高于一般脓毒症组，血清IGF-1水平则低于一般脓毒症组（P<0.05）。存活组CD8+低于死亡组，CD3+、CD4+、CD4+/CD8+高于死亡组（P<0.05）。存活组血清HMGB1水平、APACHE II评分低于死亡组，血清IGF-1水平高于死亡组（P<0.05）。Pearson相关分析显示，脓毒症患者血清HMGB1水平与CD8+、APACHE II评分呈正相关，与CD3+、CD4+、CD4+/CD8+呈负相关（P<0.05）；血清IGF-1水平与CD8+、APACHE II评分呈负相关，与CD3+、CD4+、CD4+/CD8+呈正相关（P<0.05）。结论：脓毒症血清HMGB1、T淋巴细胞亚群、IGF-1均存在异常变化，可用于评估脓毒症患者的病情和预后。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the changes of serum high mobility group protein 1 (HMGB1) and insulin-like growth factor-1 (IGF-1) levels in sepsis patients and their relationship with T lymphocyte subsets and prognosis. Methods: 139 sepsis patients who were admitted to our hospital from February 2016 to December 2018 were selected. According to defined by sepsis 3.0, sepsis patients were divided into general sepsis group (n=73) and sepsis shock group (n=66). According to the outcome data after 28 days in ICU, the patients were divided into survival group and death group. The serum IGF-1, HMGB1levels, acute disease physiology and chronic health assessment system II (APACHE II) scores and T lymphocyte subsets were compared in sepsis patients with different severity and prognosis. Pearson correlation analysis was used to analyze the relationship between serum HMGB1, IGF-1 levels and T lymphocyte subsets, APACHE II scores. Results: The CD8+, CD4+, CD4+/CD8+ in general sepsis group were higher than those in septic shock group, and CD8+ was lower than that in septic shock group (P<0.05). The serum HMGB1 level and APACHE II scores in septic shock group were higher than those in general septic group, while the serum IGF-1 level was lower than that in general septic group (P<0.05). CD8+ in the survival group was lower than that in the death group, and CD3+, CD4+, CD4+/CD8+ were higher than those in the death group(P<0.05). The serum HMGB1 level and APACHE II scores in the survival group were lower than those in the death group, and the serum IGF-1 level was higher than that in the death group (P<0.05). Pearson correlation analysis showed that HMGB1 was positively correlated with CD8+, APACHE II scores, negatively correlated with CD3+, CD4+, CD4+/CD8+ (P<0.05). Serum IGF-1 level was negatively correlated with CD8+, APACHE II scores, and positively correlated with CD3+, CD4+, CD4+/CD8+ (P<0.05). Conclusion: There are abnormal changes in serum HMGB1, T lymphocyte subsets and IGF-1 in sepsis patients. It can be used to evaluate the condition and prognosis of sepsis patients. |
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