| 亚拉盖,梁 琨,锡林塔娜,陶娜拉,刘 燕.ABCA1基因多态性R219K与帕金森症和阿尔兹海默症发病率的相关性研究[J].,2020,(9):1733-1736 |
| ABCA1基因多态性R219K与帕金森症和阿尔兹海默症发病率的相关性研究 |
| Correlation between ABCA1 Gene Polymorphism R219K and the Incidence of Parkinson's Disease and Alzheimer's Disease |
| 投稿时间：2019-11-12 修订日期：2019-11-30 |
| DOI：10.13241/j.cnki.pmb.2020.09.028 |
| 中文关键词: 三磷酸腺苷结合盒转运体A1 基因多态性 帕金森症 阿尔兹海默症 |
| 英文关键词: Adenosine triphosphate binding cassette transporter A1 Gene polymorphism Parkinson's disease Alzheimer's disease |
| 基金项目:内蒙古自治区自然科学基金项目（2016BS0315）；内蒙古自治区人民医院院内基金项目（201718） |
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| 摘要 目的：探讨与研究三磷酸腺苷结合盒转运体A1(Adenosine triphosphate (ATP)-binding cassette transporter A1)基因多态性R219K与帕金森症(Parkinson disease，PD)和阿尔兹海默症(Alzheimer disease，AD)发病率的相关性。方法：选择2016年2月到2019年8月在本院门诊与住院的帕金森症患者42例作为PD组，同期选择本院门诊与住院的阿尔兹海默症患者42例作为AD组，同期选择本院门诊健康体检者84例作为对照组。调查入选者的一般资料，检测三组血液样本的ABCA1基因多态性R219K情况并进行相关性分析。结果：AD组低密度脂蛋白（low-density lipoprotein， LDL-C）、总胆固醇（total cholesterol，TC）、甘油三酯（triglyceride，TG）与尿酸(Uric acid，UA)均低于对照组，而高密度脂蛋白（high-density lipoprotein，HDL-C）、同型半胱氨酸(homocysteine，Hcy)值高于对照组(P<0.05)；AD组TC均低于PD组，而HDL高于PD组。PD患者HDL-C均低于对照组，而LDL、TC和TG与对照组无差异(P>0.05)，三组空腹血糖(Fasting blood glucose，FBG)值对比差异无统计学意义(P>0.05)。PD组与AD组的ABCA1 R219K GA基因型、A等位基因频率都显著高于对照组(P<0.05)，PD组与AD组对比差异无统计学意义(P>0.05)。在168例入选者中，直线相关分析显示ABCA1 R219K GA基因型与A等位基因与帕金森症或阿尔兹海默症发生有显著相关性(P<0.05)。结论：ABCA1基因多态性R219K在帕金森症和阿尔兹海默症患者中比较常见，ABCA1 R219K GA基因型与A等位基因可诱发帕金森症和阿尔兹海默症的发生。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate and study the relation of Adenosine triphosphate (ATP)-binding cassette transporter A1 gene polymorphism R219K and the incidence of Parkinson disease (PD), Alzheimer disease (AD). Methods: From February 2016 to August 2019, A total of 42 patients with Parkinson's disease who were admitted to our hospital were enrolled in the PD group, 42 patients with Alzheimer's disease who were admitted to the hospital and hospitalized in the same period as the AD group, and the other 84 healthy subjects in our outpatient clinic were selected as the control group. The general information of the selected subjects were investigated, and the ABCA1 gene polymorphism R219K of the three groups of blood samples were examined and correlated. Results: The LDL-C, TC, TG and UA in the AD group were lower than those in the control group, while the HDL-C and Hcy values were higher than those in the control group (P<0.05). The TC in the AD group was lower than that in the PD group, and the HDL was higher than the PD group. The HDL-C level of PD patients was lower than that of the control group, but LDL, TC and TG were not different from the control group (P>0.05). There was no significant difference in the FBG values between the three groups (P>0.05). The ABCA1 R219K GA genotype, AA genotype and A allele frequency of PD group and AD group were significantly higher than that of the control group (P<0.05), and there were no significant difference compared between PD group and AD group (P>0.05). In the 168 case, linear correlation analysis showed that ABCA1 R219K GA genotype, AA genotype and A allele were significantly associated with Parkinson's disease or Alzheimer's disease (P<0.05). Conclusion: The ABCA1 gene polymorphism R219K are more common in patients with Parkinson's disease and Alzheimer's disease. ABCA1 R219K GA genotype, AA genotype and A allele can induce the occurrence of Parkinson's disease and Alzheimer's disease. |
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