| 刘 爽,马文成,张贤英,隋 强,王 伟.过敏性鼻炎患者血清IL-8、IL-22及TNF-α水平的变化及其与病情严重程度的关系研究[J].,2020,(9):1716-1719 |
| 过敏性鼻炎患者血清IL-8、IL-22及TNF-α水平的变化及其与病情严重程度的关系研究 |
| Changes in Serum IL-8, IL-22 and TNF-α Levels in Patients with Allergic Rhinitis and Their Relationship with Severity of the Disease |
| 投稿时间：2020-01-10 修订日期：2020-01-31 |
| DOI：10.13241/j.cnki.pmb.2020.09.024 |
| 中文关键词: 过敏性鼻炎 白介素-8 白介素-22 肿瘤坏死因子-α 过敏性鼻炎评分量表 视觉模拟量表评分 |
| 英文关键词: Allergic rhinitis Interleukin-8 InterleukinS-22 Tumor necrosis factor-α Score For Allergic Rhinitis |
| 基金项目:北京市科学技术委员会科研计划项目（D151100006322019） |
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| 中文摘要: |
| 摘要 目的：探究过敏性鼻炎患者血清白介素-8（IL-8）、白介素-22（IL-22）及肿瘤坏死因子-α（TNF-α）水平的变化及其与病情严重程度的关系。方法：选择2018年2月至2019年6月期间我院诊治的99例过敏性鼻炎患者作为鼻炎组，选择同期进行健康体检的99例健康志愿者作为健康组。采用酶联免疫吸附法检测血清IL-8、IL-22及TNF-α水平，按照世界卫生组织对过敏性鼻炎的分度标准将鼻炎组进一步分为轻度组、中度组和重度组，比较不同病情严重程度患者过敏性鼻炎评分量表（SFAR）评分、视觉模拟量表（VAS）评分以及血清IL-8、IL-22及TNF-α水平，采用Pearson相关性分析血清IL-8、IL-22及TNF-α水平与SFAR评分和VAS评分的相关性。结果：与健康组相比，鼻炎组的血清IL-8、IL-22及TNF-α水平均明显升高（P<0.05）。与轻度组相比，中度组和重度组的SFAR评分、VAS评分以及血清IL-8、IL-22及TNF-α水平明显升高，且中度组明显高于轻度组（P<0.05）。血清IL-8、IL-22及TNF-α水平与SFAR评分和VAS评分均呈正相关（P<0.05）。结论：血清IL-8、IL-22及TNF-α水平升高与过敏性鼻炎的发生密切相关，并且随患者病情加剧而上调。同时，血清IL-8、IL-22及TNF-α水平与SFAR评分和VAS评分均呈正相关性，在临床诊断过敏性鼻炎的严重程度上具有一定应用价值。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum IL-8, IL-22 and TNF-α levels and severity of allergic rhinitis. Methods: 99 cases of allergic rhinitis diagnosed and treated in our hospital from February 2018 to June 2019 were selected as the rhinitis group, and 99 cases of healthy personnel who underwent physical examination during the same period were selected as the healthy group. Enzyme-linked immunosorbent method was used to test two groups of serum IL-8, IL-22 and TNF-α level. According to the world health organization on allergic rhinitis of dividing standards, rhinitis group further divided into mild, moderate and severe groups, Score of allergic rhinitis scale (SFAR), Visual analogue scale (VAS) score and the serum levels of IL 8, IL-22 and TNF-α level were compared among three groups, the Pearson correlation between serum IL-8, IL-22, TNF-α level and SFAR score and VAS score were analyzed. Results: Compared with the healthy group, the serum levels of IL-8, IL-22 and TNF-α in the rhinitis group were significantly higher (P<0.05). Compared with the mild group, the SFAR score, VAS score, serum IL-8, IL-22 and TNF-α levels in the moderate group and the severe group were significantly higher than those in the mild group (P<0.05). Serum levels of IL-8, IL-22 and TNF-α were positively correlated with SFAR and VAS (P<0.05). Conclusion: The elevation of serum IL-8, IL-22 and TNF-α levels was closely related to the occurrence of allergic rhinitis and was up-regulated with the aggravation of the disease. At the same time, serum IL-8, IL-22 and TNF-α levels were positively correlated with SFAR score and VAS score, which had certain application value in clinical diagnosis of the severity of allergic rhinitis. |
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