| 孙艺歌,石舟红,杨田如,戴建荣,邵 丽.血清DKK1、CA125及CA199联合检测对子宫内膜癌的临床意义[J].,2020,(9):1707-1710 |
| 血清DKK1、CA125及CA199联合检测对子宫内膜癌的临床意义 |
| Clinical Significance of Combined Detection of Serum DK1, CA125 and CA199 in Endometrial Cancer |
| 投稿时间：2019-10-26 修订日期：2019-11-21 |
| DOI：10.13241/j.cnki.pmb.2020.09.022 |
| 中文关键词: 子宫内膜癌 Dickkopf相关蛋白1 糖类癌症抗原125 糖类癌症抗原199 临床意义 |
| 英文关键词: Endometrial cancer Dickkopf-related protein 1 Carbohydrate cancer antigen 125 Carbohydrate cancer antigen 199 Clinical significance |
| 基金项目:江苏省卫生和计划生育委员会面上项目（H20160132） |
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| 中文摘要: |
| 摘要 目的：探讨血清Dickkopf相关蛋白1（DKK1）、糖类癌症抗原125（CA125）及糖类癌症抗原199（CA199）联合检测对子宫内膜癌（EC）的临床意义。方法：选取2014年1月至2018年12月本院收治的162例EC患者（EC组），同时选取同期来我院体检的健康妇女50例作为对照组。采用酶联免疫检测法（ELISA）检测受试者血清中DKK1、CA125及CA199的水平，绘制受试者工作特征（ROC）曲线，比较各指标及联合检测对于EC的诊断效能。结果：EC组患者血清DKK1、CA125及CA199水平均高于对照组（P均<0.05）。EC组患者血清DKK1、CA125及CA199水平与患者年龄、组织分化程度、病理类型、淋巴结转移、脉管侵袭等无关（P均>0.05）；FIGO分期Ⅲ期患者的血清DKK1及CA199水平高于Ⅰ期、Ⅱ期患者（P均<0.05），血清CA125水平高于Ⅰ期患者（P<0.05）。联合检测血清DKK1、CA125及CA199水平，诊断EC的敏感度为76.5%，特异性为90.0%，曲线下面积（AUC）为0.888，三者联合检测的AUC值高于单独检测DKK1、CA125、CA199以及两两联合检测。结论：EC患者血清DKK1、CA125及CA199水平异常升高，且与部分临床病理特征有关，三者联合检测可能对EC具有一定的参考价值。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical significance of combined detection of serum Dickkopf-related protein 1 (DKK1), carbohydrate cancer antigen 125 (CA125) and carbohydrate cancer antigen 199 (CA199) in endometrial cancer (EC). Methods: 162 EC patients (EC group) who were admitted to our hospital from January 2014 to December 2018 were selected. At the same time, 50 healthy women who had physical examination in our hospital during the same period were selected as the control group. Detection of serum levels of DKK1, CA125 and CA199 by enzyme-linked immunosorbent assay (ELISA), the ROC Curve of subjects were drawed, and the diagnostic efficacy of each index and combined detection for EC were compared. Results: Serum levels of DKK1, CA125 and CA199 in EC group were significantly higher than those in control group (all P<0.05). In EC group, the serum levels of DKK1, CA125 and CA199 were not related with ages, tissue differentiation degree, pathological types, lymphatic metastasis and vascular invasion (all P>0.05). The serum levels of DKK1 and CA199 in FIGO stage III patients were significantly higher than those in patients with stage Ⅰ and stage Ⅱ (all P<0.05), while serum level of CA125 in patients with sage Ⅲ was significantly higher than that in patients with stage Ⅰ (P<0.05). The sensitivity of combined detection of serum DKK1, CA125 and CA199 for EC diagnosis was 76.5%, the specificity was 90.0%, the area under the curve (AUC) was 0.888. The AUC values of the three combined detection were higher than those of DKK1, CA125, CA199 and two combined detection. Conclusion: The serum levels of DKK1, CA125 and CA199 are abnormally elevated in EC patients, and they are correlated with some clinicopathological features. The combined detection of DKK1, CA125 and CA199 may have some reference value for EC. |
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