| 黄 强,蒲爱民,项锦红,李春梅,罗 莉.435例产妇产后相关激素水平的调查研究及闭经风险和抑郁状况的关系研究[J].,2020,(9):1677-1680 |
| 435例产妇产后相关激素水平的调查研究及闭经风险和抑郁状况的关系研究 |
| A study of Postpartum Hormone Levels and the Relationship between Amenorrhea Risk and Depression of 435 Cases of Postpartum Women |
| 投稿时间：2019-11-06 修订日期：2019-11-29 |
| DOI：10.13241/j.cnki.pmb.2020.09.015 |
| 中文关键词: 产妇 卵泡刺激素 促黄体生成激素 雌二醇 泌乳素 闭经 抑郁 |
| 英文关键词: Parturient Follicle stimulating hormone Luteinizing hormone Estradiol Prolactin Amenorrhea Depression |
| 基金项目:重庆市科卫联合医学科研项目（2019MSXM025） |
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| 中文摘要: |
| 摘要 目的：研究435例产妇产后相关激素水平及可能发生闭经的风险，并探讨其与抑郁状况的关系，为临床诊疗提供依据。方法：选取2017年3月到2019年5月期间我院收治的435例产妇为研究对象，根据出血情况将产妇分为出血≥400 mL组（n=26）和出血<400 mL组（n=409），根据生产产程将产妇分为产程≥36h组（n=34）和产程<36h组（n=401），根据催产素应用情况将产妇分为催产素用量≥20U组（n=41）和催产素用量<20U组（n=394），根据是否发生产后抑郁将产妇分为产后抑郁组（n=69）和无产后抑郁组（n=366），检测并对比所有产妇血清中卵泡刺激素（FSH）、促黄体生成激素（LH）、泌乳素（PRL）以及雌二醇（E2）水平。结果：出血≥400 mL组FSH、LH水平显著高于出血<400 mL组，出血≥400 mL组E2水平显著低于出血<400 mL组（P<0.05）；产程≥36h组FSH、LH水平显著高于产程<36h组，产程≥36h组E2水平显著低于产程<36h组（P<0.05）；催产素用量≥20U组FSH、LH水平显著高于催产素用量<20U组，催产素用量≥20U组E2水平显著低于催产素用量<20U组，（P<0.05）；产后抑郁组FSH、LH水平显著高于无产后抑郁组，产后抑郁组的E2水平显著低于无产后抑郁组（P<0.05）；不同组分的PRL水平比较无统计学意义（P>0.05）。结论：出血量≥400 mL、产程≥36h和催产素用量≥20U可能是闭经的风险因素，而产后抑郁可能降低产妇的卵巢功能。 |
| 英文摘要: |
| ABSTRACT Objective: To study the hormone levels and the risk of amenorrhea in 435 cases of postpartum women, and to explore the relationship between them and depression, so as to provide basis for clinical diagnosis and treatment. Methods: 435 pregnant women admitted to our hospital from March 2017 to May 2019 were selected as the research objects. According to the bleeding situation, parturient women were divided into bleeding ≥400 mL group (n=26) and bleeding <400 mL group (n=409). According to the birth process, parturients were divided into labor process ≥36h group (n=34) and labor process <36h group (n=401). According to the application of oxytocin, parturients were divided into oxytocin dosage ≥20U group (n=41) and oxytocin dosage <20U group (n=394). According to the occurrence of post natal depression, parturients were divided into postpartum depression group (n=69) and non postpartum depression group (n=366). Serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL) and estradiol (E2) were measured and compared in all parturients. Results: The levels of FSH and LH in the bleeding ≥400 mL group were significantly higher than bleeding <400 mL group, the levels of E2 in the bleeding ≥400ml group were significantly lower than bleeding <400 mL group (P<0.05); the levels of FSH and LH in the labor process ≥36h group were significantly higher than labor process <36h group, the levels of E2 in the labor process ≥36h group were significantly lower than labor process <36h group (P<0.05); the levels of FSH and LH in the oxytocin dosage ≥20U group were significantly higher than oxytocin dosage <20U group, the levels of E2 in the oxytocin dosage ≥20U group were significantly lower than oxytocin dosage <20U group (P<0.05); the levels of FSH and LH in the postpartum depression group were significantly higher than non postpartum depression group, the levels of E2 in the postpartum depression group were significantly lower than non postpartum depression group (P<0.05); the levels of PRL in different components were no statistical difference(P>0.05). Conclusion: Bleeding volume ≥400 mL, labor process ≥36h and oxytocin dosage ≥20U may be risk factors of amenorrhea, while postpartum depression may reduce the ovarian function of parturient women. |
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