| 李原超,张若琳,周 彤,曹 阳,叶 明.持续脑电双频指数监测在脓毒症相关性脑病患者中的应用价值[J].,2020,(8):1588-1591 |
| 持续脑电双频指数监测在脓毒症相关性脑病患者中的应用价值 |
| Application Value of Continuous Bispectral Index Monitoring for the Patients with Septic Encephalopathy |
| 投稿时间：2019-07-27 修订日期：2019-08-23 |
| DOI：10.13241/j.cnki.pmb.2020.08.042 |
| 中文关键词: 持续脑电双频指数 脓毒症相关性脑病 降钙素原 S100β蛋白 |
| 英文关键词: Persistent bispectral index Sepsis-related encephalopathy Procalcitonin S100β |
| 基金项目:黑龙江省博士后基金项目（LBH-Z18219） |
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| 中文摘要: |
| 摘要 目的：探讨持续脑电双频指数监测(Bispectral Index，BIS)用于脓毒症相关性脑病患者诊断及病情评估的临床应用价值。方法：选择2015年1月-2018年6月我院重症加强治疗病房(Intensive Care Unit，ICU)收治的脓毒症患者90例，其中38例患者出现脓毒症相关性脑病(脑病组)，其余52例患者为非脓毒症相关性脑病(非脑病组)。所有患者在入住ICU后进行BIS持续监测24 h，并比较两组患者的血清降钙素原(procalcitonin，PCT)、S100β水平，并分析BIS与格拉斯哥昏迷评分(glasgow coma scale，GCS)、APACHE-Ⅱ的相关性。结果：脑病组患者的血清PCT、S100β水平及急性生理健康与慢性疾病评分(Acute Physiology and Chronic Health Evaluation Ⅱ score，APACHE-II)均明显高于非脑病组(P<0.05)，而BIS值、GCS评分均明显低于非脑病组(P<0.05)。脓毒症相关性脑病患者BIS值与GCS评分呈正显著相关性(r=0.487，P=0.013)，与APACHE-II评分呈明显负相关性(r=-0.682，P=0.027)。结论：采用BIS监测脓毒症患者利于相关性脑病的及早诊断，结合检测血清PCT、S100β水平变化可能有助于判断患者的病情严重程度。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical value of continuous bispectral index monitoring (BIS) for the diagnosis and evaluation of disease severity of sepsis-related encephalopathy. Methods: Ninety-eight patients with sepsis treated in the ICU ward from January 2015 to June 2018 were selected, including 38 patients with sepsis-related encephalopathy (encephalopathy group) and 52 patients with related encephalopathy (Non-encephalopathy group). All the patients underwent continuous BIS monitoring for 24 hours after admission to the ICU, and the serum PCT and S100β levels of the two groups were compared between and after treatment, the correlation between BIS and Glasgow Coma Scale (GCS) and APACHE-II were also analyzed. Results: The levels of PCT and S100β in serum and the acute physiology and chronic health evaluation II score (APACHE-II) in patients with encephalopathy group were significantly higher than those in the non-encephalopathy group (P<0.05). The BIS and GCS scores in the encephalopathy group were significantly lower than those in the non-encephalopathy group (P<0.05). The BIS value of the patients with sepsis encephalopathy was positively correlated with the GCS score (r=0.487, P=0.013); the BIS value was negatively correlated with the APACHE-II score. (r=-0.682, P=0.027). Conclusion: BIS monitoring is helpful for the early diagnosis of sepsis-related encephalopathy. Combined with the detection of serum PCT and S100?β levels may be helpful to evaluate the disease severity. |
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