| 邢效如,郝雅男,孙 志,赵新春,袁富玲.帕金森病患者血清胱抑素C、β-淀粉样蛋白1-42检测的临床意义[J].,2020,(8):1561-1564 |
| 帕金森病患者血清胱抑素C、β-淀粉样蛋白1-42检测的临床意义 |
| Clinical Significance of Serum Cystatin C and β - Amyloid Protein 1-42 in Patients with Parkinson's Disease |
| 投稿时间：2019-11-07 修订日期：2019-11-30 |
| DOI：10.13241/j.cnki.pmb.2020.08.036 |
| 中文关键词: 帕金森病 血清胱抑素C β-淀粉样蛋白1-42 炎性因子 氧化应激 相关性 |
| 英文关键词: Parkinson's disease Serum cystatin C β-amyloid protein 1-42 Inflammatory factors Oxidative stress Correlation |
| 基金项目:天津市卫生计生委科技基金项目(2016KZ1228) |
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| 摘要 目的：探讨帕金森病(PD)患者血清胱抑素C(Cys C)、β-淀粉样蛋白1-42(Aβ1-42)检测的临床意义。方法：选取2018年1月~2019年12月期间本院收治的帕金森病患者97例为研究对象纳入观察组，根据Hoehn-Yahr(H&Y)病情分期将观察组患者分为早期组(32例)、中期组(37例)、晚期组(28例)，另选同期在我院进行体检的健康受试者50例为对照组。对各组受试者的血清Cys C、Aβ1-42、炎性因子、氧化应激指标等进行检测对比，并采用Pearson检验对PD患者的Cys C、Aβ1-42与炎性指标、氧化应激指标的相关性进行分析。结果：观察组血清Cys C、白介素-1β(IL-1β)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、丙二醛(MDA)水平均高于对照组，Aβ1-42、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)水平均低于对照组(P<0.05)。在观察组内随着PD病情的加重，血清Cys C、IL-1β、CRP、TNF-α、MDA水平均逐渐升高，Aβ1-42、SOD、GSH-Px水平均逐渐降低，各组间对比差异有统计学意义(P<0.05)。经Pearson检验分析，PD患者的Cys C与IL-1β、CRP、TNF-α、MDA呈正相关，与SOD、GSH-Px呈负相关，Aβ1-42与IL-1β、CRP、TNF-α、MDA呈负相关，与SOD、GSH-Px呈正相关(P<0.05)。结论：PD患者血清中Cys C呈现高表达，Aβ1-42呈现低表达，其表达随着患者的病情加重而变化，并且与患者的炎症反应、氧化应激水平有密切的相关性。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the clinical significance of serum cystatin C (Cys C) and β - amyloid protein 1-42 (Aβ1-42) in patients with Parkinson's disease (PD). Methods: 97 patients with Parkinson's disease who were admitted to our hospital from January 2018 to December 2019 were included in the observation group. According to the stage of Hoehn Yahr (H & Y), the patients in the observation group were divided into early group (32 cases), middle group (37 cases) and late group (28 cases). Another 50 healthy subjects who had health examination in our hospital at the same time were selected as the control group. The serum Cys C, Aβ1-42, inflammatory factors and oxidative stress indexes of each group were detected and compared, and the correlation between Cys C, Aβ1-42, inflammatory indexes and oxidative stress indexes of patients with PD were analyzed and discussed by Pearson test. Results: The levels of serum Cys C, Interleukin-1 β (IL-1β), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), malondialdehyde (MDA) in the observation group were higher than those in the control group, and the levels of Aβ1-42, superoxide dismutase (SOD), glutathione peroxidase (GSH PX) were lower than those in the control group (P<0.05). In the observation group, with the aggravation of PD, the levels of serum Cys C, IL-1β, CRP, TNF-α and MDA increased in turn, and the levels of Aβ1-42, SOD and GSH-Px decreased in turn. There was significant difference between the groups (P<0.05). According to Pearson test, Cys C in patients with PD were positively correlated with IL-1β, CRP, TNF-α and MDA, negatively correlated with SOD and GSH-Px, Aβ1-42 were negatively correlated with IL-1β, CRP, TNF-α and MDA, positively correlated with SOD and GSH-Px (P<0.05). Conclusion: The expression of Cys C is high in patients with PD, and Aβ1-42 is low. It changes with the aggravation of patients with PD, and which is closely related to the level of inflammatory factor response and oxidative stress. |
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