| 郭 飞,薛 军,韩 磊,张晓阳,吕燕琴,李明晖,贾 倩.结直肠癌围术期营养干预对患者术后营养指标、T淋巴细胞亚群及并发症的影响[J].,2020,(7):1360-1363 |
| 结直肠癌围术期营养干预对患者术后营养指标、T淋巴细胞亚群及并发症的影响 |
| Effect of Perioperative Nutritional Intervention on Nutritional Indicators, T Lymphocyte Subsets and Complications of Patients with Colorectal Cancer |
| 投稿时间：2019-09-05 修订日期：2019-09-28 |
| DOI：10.13241/j.cnki.pmb.2020.07.035 |
| 中文关键词: 结直肠癌 围术期 营养干预 营养指标 T淋巴细胞亚群 并发症 |
| 英文关键词: Colorectal cancer Perioperative period Nutritional intervention Nutritional indicators T lymphocyte subsets Complications |
| 基金项目:河北省卫生厅科研基金项目（20180863） |
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| 中文摘要: |
| 摘要 目的：探讨结直肠癌围术期营养干预对患者术后营养指标、T淋巴细胞亚群及并发症的影响。方法：选取2017年3月~2019年3月期间我院收治的结直肠癌患者103例，根据随机数字表法将患者分为对照组（n=51）和研究组（n=52），对照组给予常规方案干预，研究组给予营养支持方案干预。比较两组围术期指标、营养指标、T淋巴细胞亚群及并发症。结果：研究组患者的排便时间、首次肛门排气时间、住院时间均短于对照组（P<0.05）。对照组术后1 d、术后7 d 的CD3+、CD4+、CD4+/CD8+均低于入院时，CD8+则高于入院时（P<0.05）；研究组术后1 d、术后7 d的CD3+、CD4+、CD4+/CD8+呈先降低后升高趋势，CD8+呈先升高后降低趋势（P<0.05）；研究组术后1 d、术后7 d的CD3+、CD4+、CD4+/CD8+高于对照组，CD8+则低于对照组（P<0.05）。两组术后1 d、术后7 d血清前清蛋白（PA）、血红蛋白（Hb）、总蛋白（TP）、转铁蛋白（TF）水平均呈先下降后升高趋势（P<0.05）；研究组术后1 d、术后7 d血清PA、Hb、TP、TF水平均高于对照组（P<0.05）。两组并发症发生率比较差异无统计学意义（P>0.05）。结论：结直肠癌围术期给予营养支持方案干预，可有效改善患者营养状态，提高免疫功能，且不增加并发症发生率，具有一定的临床应用价值。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of perioperative nutritional intervention on nutritional parameters, T lymphocyte subsets and complications of patients with colorectal cancer. Methods: 103 patients with colorectal cancer who were admitted to our hospital from March 2017 to March 2019 were aelected, they were divided into control group (n=51) and study group (n=52) according to random number table method. The control group was given routine program intervention, and the study group was given nutritional support program intervention. Perioperative indicators, nutritional indicators, T lymphocyte subsets and complications were compared between the two groups. Results: The defecation time, first anal exhaust time and hospitalization time in the study group were shorter than those in the control group(P<0.05). The CD3+, CD4+, CD4+/CD8+ in the control group were lower than those at admission 1d after operation and 7d after operation, while CD8+ was higher than those at admission(P<0.05). The CD3+, CD4+, CD4+/CD8+ in the study group decreased first and then increased, and CD8+ increased first and then decreased(P<0.05). The CD3+, CD4+, CD4+/CD8+ in the study group were higher than those in the control group at 1 d after operation, 7 d after operation, CD8+ was lower than that in control group (P<0.05). The levels of serum prealbumin (PA), hemoglobin (Hb), total protein (TP) and transferrin (TF) in the two groups decreased first and then increased (P<0.05). The levels of serum PA, Hb, TP and TF in the study group were higher than those in the control group at 1 d after operation, 7 d after operation(P<0.05). There was no significant difference in the incidence of complications between the two groups (P>0.05). Conclusion: Nutrition support program intervention in perioperative period of colorectal cancer can effectively improve the nutritional status of patients, improve immune function, and it do not increase the incidence of complications, which has a certain clinical value. |
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