| 高 凯,刘亚辉,魏婷婷,魏勇军,詹 斌,白彩恋,刘宏伟.枸地氯雷他定联合鼻窦内窥镜手术对慢性鼻窦炎患者临床症状和炎性反应的作用研究[J].,2020,(7):1285-1288 |
| 枸地氯雷他定联合鼻窦内窥镜手术对慢性鼻窦炎患者临床症状和炎性反应的作用研究 |
| Effect of Desloratadine Citrate Disodium Combined with Endoscopic Sinus Surgery on Clinical Symptoms and Inflammatory Response in Patients with Chronic Sinusitis |
| 投稿时间：2019-08-18 修订日期：2019-09-12 |
| DOI：10.13241/j.cnki.pmb.2020.07.017 |
| 中文关键词: 枸地氯雷他定 鼻窦内窥镜 慢性鼻窦炎 视觉模拟评分 炎性因子 |
| 英文关键词: Desloratadine citrate disodium Sinus endoscopy Chronic sinusitis Visual analogue score Inflammatory factors |
| 基金项目:辽宁省自然科学基金项目（20180550376） |
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| 中文摘要: |
| 摘要 目的：探讨枸地氯雷他定联合鼻窦内窥镜手术对慢性鼻窦炎患者临床症状和炎性反应的影响。方法：选取我院2017年3月-2018年7月收治的116例慢性鼻窦炎患者作为研究对象，按照随机数字表法分为传统组和联合组，每组各58例，传统组患者给予鼻窦内窥镜手术治疗，联合组在鼻窦内窥镜手术基础上联合使用枸地氯雷他定进行治疗，比较两组患者的临床疗效、症状视觉模拟量表（VAS）评分、鼻黏液纤毛清除功能、炎性因子水平及不良反应发生情况。结果：联合组患者治疗总有效率高于传统组，且联合组治疗后头痛、鼻塞、面部疼痛、嗅觉障碍的VAS评分均低于传统组（P<0.05）。治疗后两组清除率、清除速度均大于治疗前，清除时间短于治疗前（P<0.05）；与传统组相比，治疗后联合组清除率、清除速度升高，清除时间缩短（P<0.05）。治疗后两组肿瘤坏死因子-α（TNF-α）、白细胞介素-5（IL-5）、白细胞介素-12（IL-12）及超敏C反应蛋白（hs-CRP）水平均低于治疗前，且联合组低于传统组（P<0.05）。两组不良反应发生率比较差异无统计学意义（P>0.05）。结论：在鼻窦内窥镜手术治疗基础上联合使用枸地氯雷他定治疗慢性鼻窦炎患者疗效确切，有效减轻炎性反应，缓解患者临床症状。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of desloratadine citrate disodium combined with endoscopic sinus surgery on clinical symptoms and inflammatory response in patients with chronic sinusitis. Methods: 116 patients with chronic sinusitis admitted to our hospital from March 2017 to July 2018 were selected as the research objects. They were divided into traditional group and combined group according to random number table method, 58 cases in each group. The traditional group were treated with endoscopic sinus surgery. The combined group were treated with desloratadine citrate disodium on the basis of endoscopic sinus surgery. The clinical efficacy, symptom visual analogue scale (VAS) scores, clearance function of nasal mucociliary, levels of inflammatory factors and adverse reactions were compared between the two groups. Results: The total effective rate of the combined group were higher than that of the traditional group, and the VAS scores of headache, nasal obstruction, facial pain and olfactory disturbance in the combined group were lower than those in the traditional group (P<0.05). The clearance rate and clearance speed of the two groups after treatment were higher than those before treatment, and the clearance time was shorter than that before treatment(P<0.05). Compared with the traditional group, the clearance rate and clearance speed of the combined group increased and clearance time shortened after treatment(P<0.05). After treatment, the levels of tumor necrosis factorα (TNF-α), interleukin-5 (IL-5), interleukin-12 (IL-12) and high-sensitivity C-reactive protein (hs-CRP) in the two groups were lower than those before treatment, and those in the combined group were lower than those in the traditional group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: On the basis of endoscopic sinus surgery, combined use of desloratadine citrate in the treatment of chronic sinusitis patients has a definite effect, effectively alleviating inflammatory response, alleviating the clinical symptoms of patients. |
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