| 鲁 周,王 峰,王 勇,朱召迎,翟益民.蠲痹汤联合玻璃酸钠对膝关节骨性关节炎患者膝关节功能、生活质量及血清TLR4、TNF-α的影响[J].,2020,(6):1091-1094 |
| 蠲痹汤联合玻璃酸钠对膝关节骨性关节炎患者膝关节功能、生活质量及血清TLR4、TNF-α的影响 |
| Effects of Juanbi Decoction and Sodium Hyaluronate on Knee Joint Function, Quality of Life and Serum TLR4 and TNF-α in Patients with Knee Osteoarthritis |
| 投稿时间：2019-09-19 修订日期：2019-10-15 |
| DOI：10.13241/j.cnki.pmb.2020.06.020 |
| 中文关键词: 蠲痹汤 玻璃酸钠 膝关节骨性关节炎 膝关节功能 生活质量 肿瘤坏死因子-?琢 Toll样受体4 |
| 英文关键词: Juanbi decoction Sodium hyaluronate Knee osteoarthritis Knee joint function Quality of life Tumor necrosis factor-?琢 Toll-like receptor 4 |
| 基金项目:安徽省科技攻关项目（16A040801075） |
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| 中文摘要: |
| 摘要 目的：探讨蠲痹汤联合玻璃酸钠对膝关节骨性关节炎（KOA）患者膝关节功能、生活质量及血清肿瘤坏死因子-α（TNF-α）、Toll样受体4（TLR4）的影响。方法：选取2018年3月到2019年3月期间安徽中医药大学第一附属医院收治的KOA患者75例，根据数字表法将患者随机分为对照组（n=37）和研究组（n=38），对照组给予玻璃酸钠注射治疗，研究组在对照组的基础上联合蠲痹汤治疗，比较两组患者临床疗效、膝关节功能、生活质量及血清TLR4、TNF-α水平，记录两组治疗期间不良反应情况。结果：研究组治疗后的总有效率为92.11%（35/38），高于对照组的72.97%（27/37）（P<0.05）。两组治疗后视觉疼痛模拟评分量表（VAS）评分降低，且研究组低于对照组（P<0.05）；两组治疗后日本骨科协会（JOA）、关节炎生活质量量表（AIMS2-SF）评分升高（P<0.05），且JOA、AIMS2-SF评分高于对照组（P<0.05）。两组治疗后血清TNF-α、TLR4水平均降低，且研究组低于对照组（P<0.05）。两组不良反应发生率比较无差异（P>0.05）。结论：采用蠲痹汤联合玻璃酸钠治疗KOA可有效改善患者的膝关节功能及血清TLR4、TNF-α水平，并提高患者生活质量，用药安全性较好，临床应用价值较高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of Juanbi decoction combined with sodium hyaluronate on knee joint function, quality of life and serum Tumor necrosis factor-α (TNF-α), Toll-like receptor 4 (TLR4) in patients with knee osteoarthritis (KOA). Methods: 75 patients with KOA who were treated in the First Affiliated Hospital of Anhui University of Chinese Medicine from March 2018 to March 2019 were selected, they were randomly divided into control group (n=37) and study group (n=38) according to the digital table method. The control group was given sodium hyaluronate injection, and the study group was treated with Juanbi decoction on the basis of the control group. The clinical efficacy, function of knee joint, quality of life and serum TLR4 and TNF-α levels of the two groups were compared. Adverse reactions between the two groups during treatment were recorded. Results: The clinical efficacy of the study group was 92.11% (35/38) after treatment, which was significantly higher than that of the control group 72.97% (27/37) (P<0.05). After treatment, the scores of visual analogue pain scale (VAS) of both groups decreased, and those of the study group were lower than those of the control group(P<0.05). After treatment, the scores of Japanese Orthopaedic Association (JOA) and Arthritis Impact Measurement Scale2-short form (AIMS2-SF) of both groups increased (P<0.05), while the scores of JOA and AIMS2-SF were higher than those of the control group(P<0.05). The serum levels of TNF-α and TLR4 of the two groups decreased after treatment, and those of the study group were lower than those of the control group (P<0.05). There was no difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Juanbi decoction combined with sodium hyaluronate in the treatment of KOA patients can effectively improve knee joint function and the levels of serum TLR4, TNF-α, and it can improve the quality of life of patients, with good drug safety, and it has a high clinical value. |
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