| 黄正春,杨 枋,孙智强,霍明生,朱 斌,俞 欣.乳腺癌患者改良根治术后生活质量调查及复发转移的影响因素分析[J].,2020,(5):984-987 |
| 乳腺癌患者改良根治术后生活质量调查及复发转移的影响因素分析 |
| Investigation of Quality of Life of Breast Cancer Patients after Modified Radical Operation and Analysis of Influencing Factors of Recurrence and Metastasis |
| 投稿时间：2019-11-30 修订日期：2019-12-23 |
| DOI：10.13241/j.cnki.pmb.2020.05.041 |
| 中文关键词: 乳腺癌 改良根治术 生活质量 复发转移 影响因素 |
| 英文关键词: Breast cancer Modified radical mastectomy Quality of life Recurrence and metastasis Influencing factors |
| 基金项目:安徽省公益性研究联动计划项目（1604f0804026） |
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| 中文摘要: |
| 摘要 目的：调查乳腺癌患者改良根治术后生活质量，并对其复发转移的影响因素进行分析。方法：选取2012年6月~2014年6月期间于我院行改良根治术的乳腺癌患者197例，于术后3个月、术后6个月、术后12个月采用乳腺癌患者生命质量测定量表（FACT-B）评价患者生活质量。采用我院自制的调查问卷统计患者基本治疗情况，分析乳腺癌改良根治术后复发转移的影响因素。结果：本研究中，共发放197份问卷调查，回收195份，回收率为98.98%（195/197）。其中195例患者中有73例发生复发转移（复发转移组），122例未发生复发转移（未复发转移组）。195例乳腺癌患者术后3个月、术后6个月、术后12个月社会/家庭状况、生理状况、功能状况、情感状况、附加关注条目、总体生活质量等项目评分呈递增趋势（P<0.05）。多因素Logistic回归分析显示，病理类型为浸润性非特殊性癌、肿瘤大小≥2 cm、临床分期为III期、激素受体为ER及PR均阴性均是乳腺癌改良根治术后复发转移的独立危险因素（P<0.05），而采用放化疗、联合化疗方案、内分泌治疗以及p53蛋白阳性表达是乳腺癌改良根治术后复发转移的独立保护因素（P<0.05）。结论：乳腺癌患者行改良根治术后生活质量呈动态变化，其术后复发转移影响因素为病理类型、临床分期、肿瘤大小、激素受体、化疗方案、p53蛋白、内分泌治疗及放化疗。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the quality of life of breast cancer patients after modified radical operation and analyze the influencing factors of recurrence and metastasis. Methods: 197 patients with breast cancer who underwent modified radical mastectomy in our hospital from June 2012 to June 2014 were selected. The quality of life of patients with breast cancer was evaluated by Quality of life scale for breast cancer patients (FACT-B) at 3 months, 6 months and 12 months after operation. The basic treatment of breast cancer patients was analyzed by self-designed questionnaire, and the influencing factors of recurrence and metastasis after modified radical mastectomy were analyzed. Results: In this study, 197 questionnaires were sent out and 195 were recovered, the recovery rate was 98.98% (195/197). 73 of 195 patients had relapse and metastasis. 73 patients with relapse and metastasis were enrolled in the relapse and metastasis group, and 122 patients without relapse and metastasis were enrolled in the relapse and metastasis group. The scores of social / family status, physiological status, functional status, emotional status, additional items of concern, and overall quality of life of 195 cases of breast cancer showed an increasing trend (P < 0.05). The independent risk factors of recurrence and metastasis after modified radical mastectomy were infiltrative nonspecific cancer, tumor size ≥ 2 cm, clinical stage III, hormone receptor ER and PR negative (P < 0.05), while p53 protein positive expression, chemotherapy regimen, radiochemotherapy and endocrine therapy were independent protective factors of recurrence and metastasis after modified radical mastectomy (P < 0.05). Conclusion: The quality of life of patients with breast cancer after modified radical operation changes dynamically, the influencing factors of postoperative recurrence and metastasis are pathological type, clinical stage, tumor size, hormone receptor, chemotherapy plan, p53 protein, endocrine therapy, radiotherapy and chemotherapy. |
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