| 贾 静,马百涛,朱盛兰,王少帅,冯 玲.上皮剪接调节蛋白1的研究进展[J].,2020,(3):591-595 |
| 上皮剪接调节蛋白1的研究进展 |
| Research Progress of Epithelial Splicing Regulatory Protein 1 |
| 投稿时间：2019-09-30 修订日期：2019-10-23 |
| DOI：10.13241/j.cnki.pmb.2020.03.042 |
| 中文关键词: 上皮剪接调节蛋白1 选择性剪接 上皮间质转化 胚胎发育 |
| 英文关键词: Epithelial splicing regulatory protein 1 Alternative splicing Epithelial-mesenchymal transition Embryonic development |
| 基金项目:国家重点研究发展计划项目(2016YFC1000405；2018YFC1002900) |
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| 中文摘要: |
| 摘要：上皮剪接调节蛋白1( Epithelial splicing regulatory protein 1，ESRP1) 是近年来发现的一种上皮细胞特异性剪接因子，主要通过选择性剪接在转录后水平调节基因的表达，继而影响细胞的功能。研究表明，ESRP1通过调控上皮间质转化、细胞周期进展、氧化还原反应以及脂肪酸代谢等过程，多方面参与肿瘤的发生、发展和对治疗药物的反应。小鼠实验研究表明，ESRP1基因敲除可以导致多种器官发育异常，包括颅面部畸形、皮肤屏障功能受损、肾脏以及耳蜗发育不良等。此外，ESRP1还可以通过调控转录因子的活性以及非编码RNA的生成，提高小鼠成纤维细胞重编程为多能干细胞的效率并维持人胚胎干细胞的多能性。鉴于ESRP1在多个研究领域的重要性，本文对ESRP1常见的下游靶分子、信号通路、以及在生理病理环境下所发挥的功能进行阐述，以期进一步指导基础研究和临床应用。 |
| 英文摘要: |
| ABSTRACT: Epithelial splicing regulatory protein 1(ESRP1) is an epithelial cell-specific splicing factor discovered in recent years, which mainly regulates gene expression through alternative splicing after transcription and then affects cell functions. Numerous studies have shown that ESRP1 is involved in the occurrence, development and response to therapeutic drugs of tumors by regulating epithelial mesenchymal transition, cell cycle, redox reaction and fatty acid metabolism. Mouse experiments have shown that ESRP1 knockout can lead to a variety of organ development abnormalities, including cranial and facial deformity, impaired skin barrier function, kidney and cochlear dysplasia. In addition, ESRP1 can also improve the efficiency of mouse fibroblast reprogramming into pluripotent stem cells and maintain the pluripotency of human embryonic stem cells by regulating the activity of transcription factors and the generation of non-coding RNA. In view of the importance of ESRP1 in various research fields, this paper describes the common downstream target molecules, signaling pathways and functions of ESRP1 in physiological and pathological environments, in order to further guide basic research and clinical applications. |
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