| 王明章,贾 玲,尹 旭,庞 军,黄洋辉.苯巴比妥钠联合脑苷肌肽治疗新生儿缺氧缺血性脑病的疗效及对患儿血清HIF-1α、LXA4、ET-1表达的影响[J].,2020,(2):299-302 |
| 苯巴比妥钠联合脑苷肌肽治疗新生儿缺氧缺血性脑病的疗效及对患儿血清HIF-1α、LXA4、ET-1表达的影响 |
| Curative Efficacy of Sodium Phenobarbital Combined with Cattle Encephalon Glycoside and Ignotin in the Treatment of Neonatal Hypoxic-ischemic Encephalopathy and Its Effects on the Serum HIF-1α, LXA4, ET-1 Levels |
| 投稿时间：2019-10-08 修订日期：2019-10-31 |
| DOI：10.13241/j.cnki.pmb.2020.02.020 |
| 中文关键词: 新生儿缺氧缺血性脑病 脑苷肌肽注射液 苯巴比妥钠注射液 临床疗效 安全性 |
| 英文关键词: Neonatal hypoxic-ischemic encephalopathy Cattle encephalon glycoside and ignotin injection Sodium phenobarbital injection Clinical efficacy Safety |
| 基金项目:四川省卫生厅科研基金项目(120290) |
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| 中文摘要: |
| 摘要 目的：探讨苯巴比妥钠联合脑苷肌肽治疗新生儿缺氧缺血性脑病的疗效及对患儿血清缺氧诱导因子-1α(HIF-1α)、血脂氧素A4(LXA4)、内皮素-1(ET-1)表达的影响。方法：选择2013年1月至2018年3月我院接诊的88例缺氧缺血性脑病新生儿作为本研究对象，将其按照随机数表法分为试验组45例和对照组43例。对照组在常规治疗基础上给予脑苷肌肽注射液2 mL加入0.9%氯化钠溶液50 mL中静脉滴注，1次/d；试验组在对照组基础上给予苯巴比妥钠注射液肌肉注射，首次剂量10 mg/kg/次，24 h内可重复给药2~3次，24 h总剂量最高不超过30 mg/kg，之后以5 mg/kg/d的维持剂量，分2次使用，均连续治疗14 d。比较2组的临床疗效、临床症状恢复时间、治疗前后血清HIF-1α、LXA4、ET-1水平、神经行为评分(NBNA)、心理运动发育指数(PDI)、智力发育指数(MDI)的变化及不良反应的发生情况。结果：治疗后，试验组临床疗效总有效率为93.33%，显著高于对照组(76.74%，P＜0.05)，原始反射、肌肉张力、意识障碍恢复时间均明显短于对照组(P＜0.05)，血清HIF-1α、ET-1水平均明显低于对照组，而血清LXA4水平、NBNA评分、PDI评分、MDI评分明显高于对照组(P＜0.05)。两组治疗期间均未有发热、皮疹、肝肾功能障碍等不良反应发生。结论：苯巴比妥钠联合脑苷肌肽治疗新生儿缺氧缺血性脑病疗效明显优于脑苷肌肽治疗，其可有效调节血清HIF-1α、LXA4、ET-1水平，促进神经功能恢复，且安全性高。 |
| 英文摘要: |
| ABSTRACT Objective: To study the curative efficacy of sodium phenobarbital combined cattle encephalon glycoside and ignotin in treatment of neonatal hypoxic-ischemic encephalopathy and effects on serum hypoxia inducible factor-1α (HIF-1α), lipids A4(LXA4), endothelin-1(ET-1) levels. Methods: 88 patients of neonatal hypoxic-ischemic encephalopathy who received therapy from January 2013 to March 2018 in our hospital were selected as research objects, according to the random number table, those patients were divided into the 45 cases of treatment group group and the 43 cases of the control group, the control group was given 2 mL of cattle encephalon glycoside and ignotin injection and 50 mL of 0.9% sodium chloride solution by intravenous drip on the basis of routine treatment, 1 times/d; the experimental group was given sodium phenobarbital injection injection on the basis of the control group, the first dose was 10 mg/kg/time, and the total dose was no more than 30 mg/kg within 24 hours, after that, the maintenance dose of 5 mg/kg/d, 2 times were used, thye were continuous treatment of 14 d. The clinical efficacy, recovery time of clinical symptoms, the changes of serum HIF-1α, LXA4, ET-1 levels, neurobehavioral score (NBNA), psychomotor development index (PDI), mental development index (MDI) before and after treatment and the incidence of adverse reactions were compared between the two groups. Results: After treatment, the total effective rate in the experimental group was 93.33%, which was significantly higher than that of the control group(76.74%, P＜0.05), the recovery time of raw reflection, muscle tension and conscious disturbance were significantly shorter than those of the control group(P＜0.05), the serum HIF-1α and ET-1 levels were significantly lower than those of the control group, and serum LXA4 levels, NBNA score, PDI score and MDI score were significantly higher than those of the control group(P＜0.05). There were no fever, rash, liver and kidney dysfunction occurred in the two groups during treatment. Conclusion: The therapeutic effect of sodium phenobarbital combined with cattle encephalon glycoside and ignotin in the treatment of neonatal hypoxic-ischemic encephalopathy is better than that of cattle encephalon glycoside and ignotin, which can effectively regulate the serum HIF-1α, LXA4 and ET-1 levels, promote the recovery of nerve function with high safety. |
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