| 新吉夫,李 琳,杨丽萍,陆 蓓,青格勒图.雷珠单抗玻璃体内注射对早产儿视网膜病变患儿临床疗效及视网膜功能发育的影响[J].,2020,(1):131-134 |
| 雷珠单抗玻璃体内注射对早产儿视网膜病变患儿临床疗效及视网膜功能发育的影响 |
| Effect of Intravitreal Injection of Razumab on Clinical Efficacy and Retinal Function Development in Retinopathy of Prematurity |
| 投稿时间：2019-06-07 修订日期：2019-07-03 |
| DOI：10.13241/j.cnki.pmb.2020.01.029 |
| 中文关键词: 雷珠单抗 玻璃体内注射 激光治疗 早产儿视网膜病变 视网膜功能 |
| 英文关键词: Razumab Intravitreal injection Laser therapy Retinopathy of prematurity Retinal function |
| 基金项目:国家自然科学基金项目（81441108） |
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| 中文摘要: |
| 摘要 目的：探讨雷珠单抗玻璃体内注射对早产儿视网膜病变（ROP）患儿临床疗效及视网膜功能发育的影响。方法：收集2014年6月～2018年6月我院收治的80例ROP患儿，随机分为对照组和观察组各40例，对照组患儿采用激光治疗方案，观察组患儿采用雷珠单抗玻璃体内注射治疗方案。比较治疗后两组疗效和复发情况；随访6个月，采用闪光视网膜电图（F-ERG）检查治疗后视网膜功能的发育状况。结果：治疗后，观察组病变控制率明显高于对照组，病变进展率和复发率明显低于对照组（P<0.05）；F-ERG检查结果显示，对照组视杆细胞系统反应振幅较观察组明显降低，潜伏期较观察组明显延长，最大混合反应a、b波振幅明显低于观察组（P<0.05）；两组间最大混合反应波振幅比值b/a、潜伏期比较差异无统计学意义（P>0.05）。两组间视锥细胞反应a波潜伏期及a、b波振幅比较差异无统计学意义（P>0.05）；对照组视锥细胞反应b波潜伏期明显比观察组延长，震荡电位（Ops）比观察组明显降低（P<0.05）。结论：雷珠单抗玻璃体内注射治疗ROP患儿，疗效确切，操作简单且快速，视网膜功能的发育比激光治疗更趋向正常，适用于ROP患儿。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the ffect of intravitreal injection of razumab on clinical efficacy and retinal function development in retinopathy of prematurity(ROP). Methods: 80 cases of ROP were enrolled in our hospital from June 2014 to June 2018, who were randomly divided into control group and observation group with 40 cases in each group.The control group were treated by laser, while the observation group were treated by intravitreal injection of razumab. The curative effect and recurrence of the two groups were compared after treatment and the development of retinal function was examined by flash electroretinogram (F-ERG) after 6 months of follow-up. Results: After treatment, the disease control rate in the observation group were significantly higher than that in the control group, and the disease progression rate and recurrence rate were significantly lower than those in the control group (P<0.05). The results of F-ERG examination showed that the response amplitude of rod cell system in the control group were significantly lower than that in the observation group, the latency were significantly longer than that in the observation group, and the maximum mixed response a and b wave amplitude were significantly lower than that in the observation group (P<0.05). There was no significant difference in amplitude ratio b/a and latency between the two groups (P>0.05), and also no significant difference in the latency of a wave and the amplitude of a and b wave of cone cell response between the two groups (P>0.05). The latency of b wave of cone cell response in the control group were significantly longer than that in the observation group, and the Oscillatory potentials(Ops) were significantly lower than that in the observation group (P<0.05). Conclusion: Intravitreal injection of razumab is effective, simple and rapid in the treatment of children with ROP, and the development of retinal function tends to be more normal than that of laser therapy, which is suitable for children with ROP. |
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