| 马 钰,李真真,白旭升,张 巍,王彦芳,荣 晅.P16/Ki-67细胞学双染在TCT诊断为非典型鳞状细胞意义不明确(ASC-US)中的分流作用研究[J].,2020,(1):121-126 |
| P16/Ki-67细胞学双染在TCT诊断为非典型鳞状细胞意义不明确(ASC-US)中的分流作用研究 |
| Clinical Value of P16/Ki-67 Dual-stained Cytology for the Triage of Women with Atypical Squamous Cell of Undetermined Significance |
| 投稿时间：2019-05-21 修订日期：2019-06-16 |
| DOI：10.13241/j.cnki.pmb.2020.01.027 |
| 中文关键词: P16/Ki-67细胞学双染 非典型鳞状细胞-意义不明确（ASC-US） 高危型人乳头状瘤状病毒（HR-HPV） 宫颈高级别鳞状上皮内病变(HSIL) |
| 英文关键词: P16/Ki-67 dual-stained ASC-US HR-HPV HSIL |
| 基金项目:陕西省自然科学基金项目(2015JQ8321) |
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| 中文摘要: |
| 摘要 目的：分析P16/Ki-67双染在TCT（Thinprep cytologic test）诊断为非典型鳞状细胞，意义不明确（Atypical Squamous Cells of Undetermined Significance，ASC-US）的患者分流中的作用。方法：选取2016年9月-2018年9月在我院经宫颈液基细胞学检查诊断为ASC-US的434例女性患者为研究对象，采用P16/Ki-67双染、高危型HPV（High-Risk human papillomavirus，HR-HPV)检测，对比二者与宫颈组织学活检结果的相关性，并分析二者在ASC-US患者分流中的作用。结果：P16/Ki-67细胞学双染法的敏感性为78.2%，特异性为79.2%，HR-HPV法的敏感性为33.5%，特异性为62.3%。P16/Ki-67细胞学双染法在年轻组患者中检出高级别鳞状上皮内病变（high - grade squamous intraepithelial lesion, HSIL）及以上病变的敏感性为94.5%，特异性为85.7%；在年长组患者中敏感性为44.4%，特异性为74.3%。结论：P16/Ki-67细胞学双染作为一种临床应用简单、患者易于接受、价格相对低廉的生物学标志物，为宫颈癌的早期筛查提供了新的选择。同时，对于年轻患者，P16/Ki-67双染用于ASC-US的分流比HR-HPV检测具有更高的临床应用价值。 |
| 英文摘要: |
| ABSTRACT Objective: To evaluate the clinical value of P16/Ki-67 cytology for triage of women with atypical squamous cell of undetermined significance(ASC-US). Methods: A total of 434 cases diagnosed as ASC-US from Sep.2016 to Sep.2018 in our hospital were selected. Dual -stained cytology of P16/Ki-67, high-risk human papillomavirus (HR-HPV) detection, vaginal biopsy were applicated. P16/Ki-67 were compared with HR-HPV detected and pathological biopsy. Results: The sensitivity of P16/Ki-67 dual-stained was 78.2%, the specificity was 79.2%, The sensitivity of HR-HPV was 33.5%, the specificity was 62.3%, The sensitivity of P16/Ki-67 dual-stained in the group age under 35 years old was 94.5%, the specificity was 85.7%, in the group age above 35 years old, the sensitivity was 44.4%, the specificity was 74.3%. Conclusion: P16/Ki-67 dual-stained provides a new option for the early screening of cervical cancer, for simple clinical application, more acceptable and relatively inexpensive. Meanwhile, it has higher clinical application value than HR-HPV detection, especially in women under 35 years old. |
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