| 杜三军,张娅娟,孙晓冉,高会斌,于永强.幽门螺旋杆菌感染与胃癌患者血清IL-32、IL-1β、TNF-α的关系研究[J].,2019,19(24):4740-4743 |
| 幽门螺旋杆菌感染与胃癌患者血清IL-32、IL-1β、TNF-α的关系研究 |
| Study on the Relationship between Helicobacter Pylori Infection and Serum IL-32, IL-1β and TNF-α in Patients with Gastric Cancer |
| 投稿时间：2019-07-07 修订日期：2019-07-31 |
| DOI：10.13241/j.cnki.pmb.2019.24.032 |
| 中文关键词: 幽门螺旋杆菌 胃癌 白介素-32 白介素-1β 肿瘤坏死因子-α |
| 英文关键词: Helicobacter pylori Gastric cancer Interleukin-32 Interleukin-1β Tumor necrosis factor-α |
| 基金项目:河北省卫生厅科研基金项目（20180831）；张家口市科技计划项目（1821049D） |
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| 中文摘要: |
| 摘要 目的：探讨幽门螺旋杆菌（Hp）感染与胃癌患者血清白介素-32（IL-32）、白介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）水平的相关性。方法：分别选择151例胃癌患者（胃癌组）和100例健康者（对照组）作为研究对象，均采用14C尿素呼气试验检测Hp感染情况，记录Hp感染U值，根据检测结果将胃癌组分为Hp阳性组119例，Hp阴性组32例。采集所有研究对象空腹静脉血，采用酶联免疫吸附试验测定血清IL-32、IL-1β、TNF-α水平。比较胃癌组和对照组，Hp阴性组和阳性组之间血清IL-32、IL-1β、TNF-α水平、Hp感染U值的差异，Pearson相关性分析胃癌患者血清IL-32、IL-1β、TNF-α水平与Hp感染U值的相关性。结果：胃癌组患者血清IL-32、IL-1β、TNF-α水平以及Hp感染U值均高于对照组（P＜0.05），Hp阳性组血清IL-32、IL-1β、TNF-α水平以及Hp感染U值均高于Hp阴性组（P＜0.05）。胃癌患者血清IL-32、IL-1β、TNF-α水平均与Hp感染U值呈正相关（r=0.585、0.428、0.406，P＜0.05）。结论：胃癌患者Hp感染可引起血清IL-32、IL-1β、TNF-α水平升高，Hp感染、IL-32、IL-1β、TNF-α可能通过联合作用促进胃癌发生和进展。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation between Helicobacter pylori (Hp) infection and serum levels of interleukin-32 (IL-32), interleukin-1β(IL-1β) and tumor necrosis factor-α (TNF-α) in patients with gastric cancer. Methods: 151 patients with gastric cancer (gastric cancer group) and 100 healthy people (control group) were selected as the subjects of study. Hp infection was detected by 14C urea breath test, and Hp-infected U value was recorded. According to the results of detection, gastric cancer was divided into Hp positive group(119 cases) and Hp negative group(32 cases). Fasting venous blood was collected and serum levels of IL-32, IL-1β and TNF-α were measured by enzyme-linked immunosorbent assay. The differences of serum IL-32, IL-1β TNF-α levels and Hp-infected U value between gastric cancer group and control group, and Hp negative group and Hp positive group were compared. Pearson correlation analysis was used to analyze the correlation between serum levels of IL-32, IL-1β, TNF-α and Hp-infected U value in patients with gastric cancer. Results: The levels of serum IL-32, IL-1β, TNF-α and Hp-infected U value in gastric cancer group were higher than those in control group (P<0.05). The levels of serum IL-32, IL-1β, TNF-α and Hp-infected U value in Hp positive group were higher than those in Hp negative group(P<0.05). The levels of serum IL-32, IL-1β and TNF-α were positively correlated with the Hp-infected U value (r=0.585, 0.428, 0.406, P＜0.05). Conclusion: Hp infection in patients with gastric cancer can increase the levels of serum IL-32, IL-1β and TNF-α. Hp infection, IL-32, IL-1beta and TNF-alpha may promote the occurrence and progression of gastric cancer through combined action. |
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