| 车玲艳,王 剑,左 甲,沙兢兢,张卓然.小牛血清去蛋白提取物联合天麻钩藤饮对急性脑梗死患者神经功能及血液流变学的影响[J].,2019,19(24):4715-4718 |
| 小牛血清去蛋白提取物联合天麻钩藤饮对急性脑梗死患者神经功能及血液流变学的影响 |
| Effect of Bovine Serum Protein Extract Combined with Tianma Gouteng Drink on the Nerve Function and Hemorheology of Patients with Acute Cerebral Infarction |
| 投稿时间：2019-02-28 修订日期：2019-03-23 |
| DOI：10.13241/j.cnki.pmb.2019.24.026 |
| 中文关键词: 急性脑梗死 小牛血清去蛋白提取物 天麻钩藤饮 神经功能 血液流变学 |
| 英文关键词: Acute cerebral infarction Bovine serum protein extrac Tianma gouteng drink Neurologic function Hemorheology |
| 基金项目:陕西省自然科学基础研究计划-青年人才项目(2014JQ2-8050) |
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| 中文摘要: |
| 摘要 目的：分析小牛血清去蛋白提取物联合天麻钩藤饮对急性脑梗死患者神经功能及血液流变学的影响。方法：选择2015年10月至2018年10月在我院治疗的急性脑梗死患者90例为研究对象，将其随机均分两组。对照组仅采取小牛血清去蛋白提取物治疗，实验组在对照组基础上联合采用天麻钩藤饮治疗。比较两组治疗的临床总有效率、治疗前和治疗20 d后的神经功能缺损评分、日常生活能力评分和血液流变学指标的变化以及治疗期间不良反应的发生情况。结果：治疗后，实验组的总有效率为95.56%，显著高于对照组(77.78%，P＜0.05)。两组治疗后的美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale, NIHSS)和日常生活活动能力量表（Activities of Daily Living，ADL）评分均较治疗前显著升高，且实验组以上指标明显高于对照组(P＜0.05)。两组治疗后的全血高切黏度、全血低切黏、红细胞比容、血小板聚集率和纤维蛋白原较治疗前均显著降低，且实验组以上指标均显著低于对照组(P＜0.05)。结论：小牛血清去蛋白提取物联合天麻钩藤饮治疗急性脑梗死效果显著优于单用小牛血清去蛋白提取物治疗，其可更有效促进患者神经功能的恢复，提高患者生活质量，改善其血液流变学。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the effect of bovine serum protein extract combined with tianma gouteng drink on the nerve function recovery and hemorheology of patients with acute cerebral infarction. Methods: Ninety patients with acute cerebral infarction treated in our hospital from October 2015 to October 2018 were selected as the study subjects, they were randomly divided into two groups. The control group was treated with bovine serum protein extract alone, while the experimental group was treated with tianma gouteng drink on the basis of control group. The total effective rate, changes of neurological impairment score, daily living ability score and hemorheology index before and at 20 days after treatment and the occurrence of adverse reactions during treatment were compared between the two groups. Results: After treatment, the total effective rate of experimental group was 95.56%, which was significantly higher than that of the control group (77.78%, P<0.05). The scores of National Institutes of Health Stroke Scale (NIHSS) and Activities of Daily Living (ADL) in both groups after treatment were significantly higher than those before treatment, which were significantly higher than those in the control group (P<0.05). After treatment, the whole blood high tangential viscosity, whole blood low tangential viscosity, erythrocyte specific volume, platelet aggregation rate and fibrinogen in both groups were significantly lower than before treatment, and the above indexes in the experimental group were significantly lower than those in the control group (P<0.05). Conclusion: Bovine serum protein extrac combined with tianma gouteng drink is more effective than bovine serum protein extrac alone in the treatment of acute cerebral infarction. It can more effectively promote the recovery of neurological function, improve the hemorheology and quality of life. |
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